A5011886992- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Systemic Lupus Erythematosus Research
- Celiac Disease Research and Management
- Digestive system and related health
- Diet, Metabolism, and Disease
- Rheumatoid Arthritis Research and Therapies
- Obesity, Physical Activity, Diet
- Monoclonal and Polyclonal Antibodies Research
- Birth, Development, and Health
- Vitamin D Research Studies
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Microscopic Colitis
- Infant Nutrition and Health
- Nutritional Studies and Diet
- Breastfeeding Practices and Influences
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gestational Diabetes Research and Management
- Cardiovascular Disease and Adiposity
- T-cell and B-cell Immunology
Colorado School of Public Health
2016-2025
University of Colorado Denver
2015-2024
University of Colorado Anschutz Medical Campus
2015-2024
Freeman Hospital
2023
Denver Health Medical Center
1997-2020
The Medical Center of Aurora
2012-2020
657 Oslo
2018
University of Colorado System
2017
Colorado Department of Public Health and Environment
2016
Walter Reed National Military Medical Center
2015
OBJECTIVE Few studies have assessed the role of specific gastrointestinal infections in celiac disease. We investigated whether increased frequency rotavirus infection, a common cause infection and inflammation, predicts risk disease autoimmunity. METHODS A cohort 1,931 children from Denver metropolitan area who carried human leukocyte antigen (HLA) alleles were followed infancy for development autoimmunity, defined as positivity at two or more subsequent clinic visits tissue...
Dietary exposures in infancy have been implicated, albeit inconsistently, the etiology of type 1 diabetes mellitus (DM).To examine association between cereal infant diet and appearance islet autoimmunity (IA).Birth cohort study conducted from 1994 to 2002 with a mean follow-up 4 years.Newborn screening for HLA was done at St Joseph's Hospital Denver, Colo. First-degree relatives DM individuals were recruited Denver metropolitan area.We enrolled 1183 children increased risk, defined as either...
Rheumatoid arthritis (RA) is a prototypical autoimmune affecting nearly 1% of the world population and significant cause worldwide disability. Though prior studies have demonstrated appearance RA-related autoantibodies years before onset clinical RA, pattern immunologic events preceding development RA remains unclear. To characterize evolution autoantibody response in preclinical phase we used novel multiplex autoantigen array to evaluate anti-citrullinated protein antibodies (ACPA)...
From the late 1970s to early 1990s, studies found that mortality rates for pulmonary fibrosis were increasing. Recent data from are unavailable.We sought determine in United States 1992 through 2003.Using National Center Health Statistics, we calculated age-adjusted deaths of persons with and stratified differences by age, sex, race/ethnicity, geography decedent. We developed a multivariable model predict future rates, determined underlying cause death patients fibrosis.From 2003, there...
Cod liver oil supplements in infancy have been associated with a decreased risk of type 1 diabetes mellitus retrospective study.To examine whether intakes omega-3 and omega-6 fatty acids are the development islet autoimmunity (IA) children.A longitudinal, observational study, Diabetes Autoimmunity Study Young (DAISY), conducted Denver, Colorado, between January 1994 November 2006, 1770 children at increased for diabetes, defined as either possession high HLA genotype or having sibling parent...
Probiotics have been hypothesized to affect immunologic responses environmental exposures by supporting healthy gut microbiota and could therefore theoretically be used prevent the development of type 1 diabetes mellitus (T1DM)-associated islet autoimmunity.
To evaluate the presence of pulmonary abnormalities in rheumatoid arthritis (RA)-related autoantibody-positive subjects without inflammatory arthritis.Forty-two who did not have but were positive for anti-cyclic citrullinated peptide antibodies and/or ≥2 factor isotypes (a profile that is 96% specific RA), 15 autoantibody-negative controls, and 12 patients with established seropositive early RA (<1-year duration) underwent spirometry high-resolution computed tomography (HRCT) lung...
To examine the relationship of Porphyromonas gingivalis to presence autoantibodies in individuals at risk rheumatoid arthritis (RA).Study participants included following: 1) a cohort enriched subjects with HLA-DR4 and 2) RA by virtue having first-degree relative RA. None study satisfied American College Rheumatology 1987 classification criteria for Autoantibodies measured anti-citrullinated protein antibody (ACPA; second-generation anti-cyclic citrullinated peptide enzyme-linked...
To evaluate the generation of rheumatoid arthritis (RA)-related autoantibodies in lung.Simultaneous collection serum and induced sputum was performed 21 healthy controls, 49 at-risk subjects without inflammatory but at risk RA due to family history or seropositivity for anti-citrullinated protein antibodies, 14 with early RA. Samples were tested anti-cyclic citrullinated peptide 2 (anti-CCP2), anti-CCP3, anti-CCP3.1, factor isotypes IgM, IgG, IgA, total IgA.One more present 39% seronegative...
Abstract Background Although breastfeeding is touted as providing many health benefits to infants, some aspects of this relationship remain poorly understood. Methods The Environmental Determinants Diabetes in the Young (TEDDY) a prospective longitudinal study that follows children from birth through childhood, and collects data on illness events, duration, time introduction formula or foods at 3 month intervals up until 4 years age 6 months thereafter. Exclusive non-exclusive examined...
Diabetes Autoimmunity Study in the Young (DAISY) has followed 1972 children for islet autoimmunity and diabetes: 837 first-degree relatives of persons with type 1 diabetes 1135 general population newborns identified through human leukocyte antigen (HLA) screening. During follow-up 4.06 yr (range, 0.17–9 yr), serial determination autoantibodies to glutamic acid decarboxylase, protein tyrosine phosphatase IA2, insulin generated approximately 20,000 results. Among 162 at least one positive...
The relationship between insulin sensitivity and overall obesity is well established. However, there remains debate as to which of the fat depots, visceral abdominal tissue (VAT) or subcutaneous (SAT), greater importance. Also, distribution secretion largely unknown. We studied SI, acute response (AIR), disposition index (DI), obtained by minimal model analysis, in 999 Hispanic 458 African-American men women part Insulin Resistance Atherosclerosis Study (IRAS) Family Study. VAT SAT were...
OBJECTIVE. Early exposure to solid foods in infancy has been associated with the development of allergy. The aim this study was examine association between cereal-grain exposures (wheat, barley, rye, oats) infant diet and wheat METHODS. A total 1612 children were enrolled at birth followed mean age 4.7 years. Questionnaire data dietary obtained 3, 6, 9, 15, 24 months annually thereafter. main outcome measure parent report Children celiac disease autoimmunity detected by tissue...
Vitamin D deficiency is associated with many adverse health outcomes, yet little known about the genetic epidemiology of vitamin or its metabolites.Our objective was to examine relationship among three D-related genes and levels 25-hydroxyvitamin [25(OH)D] 1,25-dihydroxyvitamin [1,25(OH)2D] in Hispanics (HAs) African Americans (AAs).The cross-sectional Insulin Resistance Atherosclerosis Family Study recruited examined subjects in: Los Angeles, California (AAs; 513 individuals from 42...
Type 1A diabetes (T1D) is an autoimmune disorder the risk of which increased by specific HLA DR/DQ alleles [e.g., DRB1*03-DQB1*0201 (DR3) or DRB1*04-DQB1*0302 (DR4)]. The genotype associated with highest for T1D DR3/4-DQ8 (DQ8 DQA1*0301, DQB1*0302) heterozygous genotype. We determined HLA-DR and -DQ genotypes at birth analyzed siblings patients identical-by-descent haplotype sharing (the number haplotypes inherited in common between siblings). children were clinically followed prospective...