A5004564167- Schizophrenia research and treatment
- Attention Deficit Hyperactivity Disorder
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Psychology and Mental Health
- Youth, Drugs, and Violence
- Electroconvulsive Therapy Studies
- Transcranial Magnetic Stimulation Studies
- Treatment of Major Depression
- Obsessive-Compulsive Spectrum Disorders
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Hallucinations in medical conditions
- Neural and Behavioral Psychology Studies
- Child and Adolescent Psychosocial and Emotional Development
- Diet and metabolism studies
- Autism Spectrum Disorder Research
- Nerve injury and regeneration
- Psychosomatic Disorders and Their Treatments
- Health, Nursing, Elderly Care
- Neurotransmitter Receptor Influence on Behavior
- Mental Health and Psychiatry
- Eating Disorders and Behaviors
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
Universidade Federal do Rio Grande do Sul
2013-2024
Hospital de Clínicas de Porto Alegre
2010-2023
Hospital Moinhos de Vento
2015-2023
National Council for Scientific and Technological Development
2022
Fundação de Amparo à Pesquisa do Estado de São Paulo
2022
Universidade Federal do Rio Grande
2021
Universidade de Ribeirão Preto
2014
Universidade de São Paulo
2014
Alberta Hospital Edmonton
2014
Alberta Health Services
2014
OBJECTIVE: Previous reports suggest that cytokines act as potential mediators of the interaction between immune and neuroendocrine systems, a proinflammatory state may be associated with bipolar disorder schizophrenia. The aim is to compare cytokine levels in both disorders. METHOD: Twenty euthymic patients, 53 chronic stabilized schizophrenia patients 80 healthy controls were recruited. Subjects all non-smokers non-obese. Cytokines TNF-α, IL-6, IL-10 examined by sandwich ELISA. RESULTS:...
Schizophrenia has been defined as a neurodevelopmental disease that causes changes in the process of thoughts, perceptions, and emotions, usually leading to mental deterioration affective blunting. Studies have shown altered cell respiration oxidative stress response schizophrenia; however, most knowledge acquired from postmortem brain analyses or nonneural cells. Here we describe neural cells, derived induced pluripotent stem cells generated skin fibroblasts schizophrenic patient, presented...
The treatment of schizophrenia remains a challenge, and the currently available antipsychotic drugs are slow acting produce number adverse effects.To examine effectiveness safety single intravenous administration sodium nitroprusside (0.5 μg/kg/min for 4 hours) on positive, negative, anxiety, depressive symptoms in patients with schizophrenia.Single-center, randomized, double-blind, placebo-controlled trial performed from March 9, 2007, to 12, 2009.University teaching hospital São Paulo,...
Background Course and predictors of persistence attention deficit hyperactivity disorder (ADHD) in adults are still largely unknown. Neurobiological clinical differences between child adult ADHD raise the need for follow-up studies patients diagnosed during adulthood. This study investigates possibility full remission 7 years after baseline assessment. Method A 7-year with ( n = 344, mean age 34.1 years, 49.9% males) was conducted. Variables from different domains (social demographics,...
Article Abstract Background: Glutamate deregulation may be involved in the neuropathology of schizophrenia, mainly through N-methyl-d-aspartate (NMDA) receptor dysfunction. Memantine, a drug approved by FDA for treatment moderate to severe Alzheimer's disease, acts as weak nonselective NMDA antagonist. The aim this study was examine efficacy memantine an adjunctive clozapine patients with refractory schizophrenia. Method: In double-blind, placebo-controlled study, outpatients schizophrenia...
Abstract Since approximately 70% of adult patients with attention-deficit/hyperactivity disorder (ADHD) have at least one comorbid disorder, rating impairment specifically attributable to ADHD is a hard task. Despite the evidence linking environmental adversities negative outcomes in ADHD, life events measures not been used rate impairment. The present study tested for first time hypothesis that increased severity associated an increase recent events, independently comorbidity status....
Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF signaling is thought to contribute the pathogenesis of schizophrenia (SZ) especially relation cognitive deficits. Clozapine (CLZ) has been shown beneficial effect on cognition SZ some studies detrimental others. To examine serum BDNF, two groups chronically medicated DSM-IV patients (n=44), treatment with clozapine (n=31) typical antipsychotics (n=13) had 5ml blood samples...
Background: Patients with schizophrenia (SZ) are generally overweight or obese and have several metabolic disorders. Additionally, such patients a lower life expectancy the main cause of their increased mortality is cardiovascular disease (CVD). The objective this study was to determine efficacy resveratrol supplementation on serum glucose CVD risk factors in individuals SZ. Methods Results: This four-week randomized, double-blind controlled trial (registration No.: NCT 02062190) which 19...
Background: Schizophrenia is associated with psychotic experiences and cognitive deficits. Therefore, function one of the most critical determinants quality life in this pathology. Resveratrol has been related neuroprotective action but there are no studies evaluating resveratrol schizophrenia. The objective study was to determine efficacy supplementation on cognition individuals Methods: This a 1-month randomized, double-blind controlled trial (NCT 02062190), which 19 men diagnosis...
Schizophrenia is a neurodevelopmental disorder with genetic and environmental factors contributing to its pathogenesis, although the mechanism unknown due difficulties in accessing diseased tissue during human neurodevelopment. The aim of this study was find neuronal differentiation genes disrupted schizophrenia evaluate those post-mortem brain tissues from cases controls. We analyzed differentially expressed (DEG), copy number variation (CNV) differential methylation induced pluripotent...
O diagnóstico do transtorno de déficit atenção e hiperatividade (TDAH) oposição desafiante (TOD) em adultos carece instrumentos adequados. Esta investigação visa avaliar a confiabilidade entre observadores das seções K-SADS-E adaptadas para os diagnósticos destes transtornos adultos. As adaptações realizadas se limitaram ao direcionamento perguntas próprio paciente, início dos sintomas um período mais tardio abordagem próprios Seis avaliadores treinados pontuaram 16 entrevistas gravadas. Os...