A5051601958- Amyotrophic Lateral Sclerosis Research
- RNA Research and Splicing
- Neurogenetic and Muscular Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Natural product bioactivities and synthesis
- Cholinesterase and Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Pluripotent Stem Cells Research
- Animal Nutrition and Physiology
- Prion Diseases and Protein Misfolding
- Plant Toxicity and Pharmacological Properties
- Bioactive natural compounds
- Aquaculture Nutrition and Growth
- Chemical Synthesis and Analysis
- Neurological diseases and metabolism
- Medicinal Plants and Neuroprotection
- Drug Transport and Resistance Mechanisms
- Bioactive Natural Diterpenoids Research
- CRISPR and Genetic Engineering
- Economic and Environmental Valuation
- Protein purification and stability
- Pharmacological Effects of Medicinal Plants
University of Sheffield
2019-2025
Universidade Federal da Bahia
2014-2024
University of Siena
2024
Universidade Federal Rural do Rio de Janeiro
2023-2024
Universidade Estadual do Oeste do Paraná
2021
Universidade Federal do Rio de Janeiro
2010-2020
Instituto de Saúde
2009
Universidade Estadual Paulista (Unesp)
2003
Amyotrophic lateral sclerosis (ALS) is a complex disease that leads to motor neuron death. Despite heritability estimates of 52%, genome-wide association studies (GWASs) have discovered relatively few loci. We developed machine learning approach called RefMap, which integrates functional genomics with GWAS summary statistics for gene discovery. With transcriptomic and epigenetic profiling neurons derived from induced pluripotent stem cells (iPSCs), RefMap identified 690 ALS-associated genes...
Schizophrenia has been defined as a neurodevelopmental disease that causes changes in the process of thoughts, perceptions, and emotions, usually leading to mental deterioration affective blunting. Studies have shown altered cell respiration oxidative stress response schizophrenia; however, most knowledge acquired from postmortem brain analyses or nonneural cells. Here we describe neural cells, derived induced pluripotent stem cells generated skin fibroblasts schizophrenic patient, presented...
Neurodegenerative disorders (ND) are characterized by the progressive and irreversible loss of neurons. Alzheimer's Disease (AD) is most incident age-related ND, in which presence a chronic inflammatory compound seems to be related its pathogenesis. Different stimuli central nervous system (CNS) can induce activation, proliferation, changes phenotype glial function, modulated anti-inflammatory agents. Apigenin (4,5,7-trihydroxyflavone) flavonoid found abundance many fruits vegetables, that...
Introdução: A Síndrome de Burnout é um problema crescente entre profissionais enfermagem, afetando negativamente a saúde física, mental e emocional, além da qualidade do cuidado prestado aos pacientes. Objetivo: Este estudo investiga prevalência, fatores risco impacto dessa síndrome, buscando entender suas implicações identificar estratégias prevenção intervenção. Metodologia: O uma Revisão Integrativa Literatura, caráter exploratório descritivo, utilizando abordagem qualitativa, conforme...
Abstract Astrocytes are highly specialised cells, responsible for CNS homeostasis and neuronal activity. Lack of human in vitro systems able to recapitulate the functional changes affecting astrocytes during ageing represents a major limitation studying mechanisms potential therapies aiming preserve health. Here, we show that induced from fibroblasts donors their childhood or adulthood display age‐related transcriptional differences functionally diverge spectrum age‐associated features, such...
Abstract Amyotrophic lateral sclerosis (ALS) lacks a specific biomarker, but is defined by relatively selective toxicity to motor neurons (MN). As others have highlighted, this offers an opportunity develop sensitive and biomarker based on detection of DNA released from dying MN within accessible biofluids. Here we performed whole genome bisulfite sequencing (WGBS) iPSC-derived neurologically normal individuals. By comparing methylation with atlas tissue derived MN-specific signature...
O estudo teve como objetivo realizar uma revisão de literatura sobre o diagnóstico da Síndrome Eagle e do alongamento processo estilóide através radiografias panorâmicas, analisando a eficácia dessa técnica na identificação condição. Trata-se narrativa literatura. Foram realizadas buscas nas bases dados PubMed, LILACS Google Acadêmico, utilizando descritores relacionados à ao em panorâmicas. incluídos estudos publicados entre 2009 2024, português, inglês ou espanhol, que apresentaram...
Three-dimensional (3D) cultures, so-called organoids, have emerged as an attractive tool for disease modeling and therapeutic innovations. Here, we aim to determine if boundary cap neural crest stem cells (BC) can survive differentiate in gelatin-based 3D bioprinted bioink scaffolds order establish enabling technology the fabrication of spinal cord organoids on a chip. BC previously demonstrated ability support survival differentiation co-implanted or co-cultured supported motor neuron...
We tested the effects of mouse embryonic stem cells (mES) grafts in mice spinal cord injury (SCI). Young adult female C57/Bl6 were subjected to laminectomy at T9 and 1-minute compression with a vascular clip. Four groups analyzed: (Sham), injured (SCI), vehicle (DMEM), mES-treated (EST). mES pre-differentiated retinoic acid injected (8 × 105 cells/2 μl) into lesion epicenter, 10 min after SCI. Basso scale (BMS) Global mobility test (GMT) assessed weekly up 8 weeks, when morphological...
Flavonoids have key functions in the regulation of multiple cellular processes; however, their effects been poorly examined pluripotent stem cells. Here, we tested hypothesis that neurogenesis induced by all-trans retinoic acid (RA) is enhanced agathisflavone (FAB, Caesalpinia pyramidalis Tull). Mouse embryonic (mES) cells and (miPS) growing as embryoid bodies (EBs) for 4 days were treated with FAB (60 μM) and/or RA (2 additional days. did not interfere EB mitotic rate mES cells, evidenced...
Inflammation and oxidative stress are common aspects of most neurodegenerative diseases in the central nervous system. In this context, microglia astrocytes to mediating balance between neuroprotective neurodestructive mechanisms. Flavonoids have potent anti-inflammatory antioxidant properties. Here, we examined potential flavonoid agathisflavone (FAB), which is derived from Brazilian plant Poincianella pyramidalis, vitro models neuroinflammation. Cocultures neurons/glial cells were exposed...
Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease caused by the selective progressive death of motor neurons (MNs). Understanding genetic molecular factors influencing ALS survival crucial for management therapeutics. In this study, we introduce deep learning-powered analysis framework to link rare noncoding variants survival. Using data from human induced pluripotent stem cell (iPSC)-derived MNs, method prioritizes functional using learning, links...
Prosopis juliflora is a shrub largely used for animal and human consumption. However, ingestion has been shown to induce intoxication in animals, which characterized by neuromuscular alterations induced mechanisms that are not yet well understood. In this study, we investigated the cytotoxicity of total alkaloid extract (TAE) one fraction (F32) obtained from P. leaves rat cortical neurons glial cells. Nuclear magnetic resonance characterization F32 showed composed mixture two piperidine...
Recent evidence shows that aminochrome induces glial activation related to neuroinflammation. This dopamine derived molecule formation and stabilization of alpha-synuclein oligomers, mitochondria dysfunction, oxidative stress, dysfunction proteasomal lysosomal systems, endoplasmic reticulum stress disruption the microtubule network, but until now there has been no effects on production cytokines neurotrophic factors, are mechanisms involved in neuronal loss Parkinson's disease (PD). study...
Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation thousands RNA molecules with roles multiple cellular pathways hinders the identification ALS-causing alterations over downstream changes secondary neurodegenerative process. How many which these pathological gene expression require therapeutic normalisation remains a fundamental question.Here, we investigated genome-wide C9ORF72-ALS patient-derived Drosophila, as well upon...