A5009743972- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Synthesis and Characterization of Pyrroles
- Immune cells in cancer
- Bioactive Natural Diterpenoids Research
- Genomics, phytochemicals, and oxidative stress
- Cholinesterase and Neurodegenerative Diseases
- Phytochemistry and Biological Activities
- Computational Drug Discovery Methods
- Phytochemistry and Bioactivity Studies
- Cyclopropane Reaction Mechanisms
- Ginkgo biloba and Cashew Applications
- Flavonoids in Medical Research
- Enzyme function and inhibition
- Catalytic C–H Functionalization Methods
Universidade Federal da Bahia
2017-2023
Instituto de Saúde
2017
The enhancement of cholinergic functions via acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition is considered a valuable therapeutic strategy for the treatment Alzheimer's disease. This study aimed to evaluate in vitro effect ZINC390718, previously filtered using computational approaches, on both cholinesterases characterize, molecular dynamics (MD) simulation, possible binding mode this compound inside cholinesterase enzymes. cytotoxicity was also investigated primary...
Amburana cearensis (Allemao) A.C.Sm. is a medicinal plant of the Brazilian Caatinga reported to present antioxidant and anti-inflammatory activity. This study aimed evaluate neuroprotective effect extracts obtained from seeds A. in primary cultures cerebellar cells subjected excitotoxicity induced by glutamate brain mitochondria submitted oxidative stress.and methods: Primary were treated with ethanol (ETAC), hexane (EHAC), dichloromethane (EDAC) ethyl acetate (EAAC) A.cearensis (10µM)....
The flavonoid apigenin, extracted from the Brazilian plant Croton betulaster Müll. has demonstrated ability to inhibit proliferation, induce differentiation, and modify inflammatory profile of glioma cells. aim present study was evaluate effect apigenin on chemotaxis regulation cytokines microglia cells these impacts cell growth. In cultures isolated rat microglia, it observed that induced changes in Iba1-positive an ameboid phenotype, associated increase expression activated M1 marker OX-42...
Multifunctionalized 2‐pyrrolinones were synthesized from the formal aza‐[3 + 2] cycloaddition reaction of acyclic enaminones and diphenylcyclopropenone. For primary enaminones, solventless under microwave heating was developed. On other hand, catalysis by Bi 2 O 3 conventional more suitable strategy when secondary employed. These conditions allowed synthesis a set with two vicinal phenyl substituents, which evaluated for cytotoxicity against U251 C6 glioblastoma cells. In general, all tested...