A5056379062- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- History of Colonial Brazil
- Blood groups and transfusion
- Natural product bioactivities and synthesis
- Parkinson's Disease Mechanisms and Treatments
- Phytochemistry and Biological Activities
- Blood transfusion and management
- Nerve injury and regeneration
- Flavonoids in Medical Research
- Toxoplasma gondii Research Studies
- Plant Toxicity and Pharmacological Properties
- Tryptophan and brain disorders
- Environmental Sustainability and Education
- Stress Responses and Cortisol
- Plant tissue culture and regeneration
- Erythrocyte Function and Pathophysiology
- Herpesvirus Infections and Treatments
- Medicinal Plants and Neuroprotection
- MicroRNA in disease regulation
- Ginkgo biloba and Cashew Applications
- Science and Education Research
- Antioxidant Activity and Oxidative Stress
- Bioactive natural compounds
- Genomics, phytochemicals, and oxidative stress
Universidade Federal da Bahia
2016-2025
National Council for Scientific and Technological Development
2019-2025
Universidade Federal do Rio de Janeiro
2025
Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional
2024
Instituto de Saúde
2002-2020
Instituto Nacional de Ciência e Tecnologia em Excitotoxicidade e Neuroproteção
2020
Universidade Federal de Mato Grosso
2001-2020
Hospital Ana Nery
2004-2019
Neurodegenerative disorders (ND) are characterized by the progressive and irreversible loss of neurons. Alzheimer's Disease (AD) is most incident age-related ND, in which presence a chronic inflammatory compound seems to be related its pathogenesis. Different stimuli central nervous system (CNS) can induce activation, proliferation, changes phenotype glial function, modulated anti-inflammatory agents. Apigenin (4,5,7-trihydroxyflavone) flavonoid found abundance many fruits vegetables, that...
The imbalance between the overproduction of reactive species and antioxidant mechanisms can result in astrogliosis oxidative stress associated with neurodegeneration. Based on described activity naturally occurring flavonoids, this study evaluated flavonoid naringenin senecioic acid ester derivatives cortical astrocytes. Naringenin (S)-naringenin were purified from Citrus paradisi, them 7,4-O-disenecioic naringenin, (S)-7,4-O-disenecioic 7-O-senecioic synthesized tested for by free-radical...
MicroRNAs (miRs) act as important post-transcriptional regulators of gene expression in glial cells and have been shown to be involved the pathogenesis neurodegenerative diseases, including Alzheimer’s disease (AD). Here, we investigated effects agathisflavone, a biflavonoid purified from leaves Cenostigma pyramidale (Tul.), on modulating miRs inflammatory mediators activated microglia. C20 human microglia were exposed oligomers β-amyloid peptide (Aβ, 500 nM) for 4 h or lipopolysaccharide...
Glioblastomas (GBM) are malignant tumours with poor prognosis. Treatment involves chemotherapy and/or radiotherapy; however, there is currently no standard treatment for recurrence, and prognosis remains unfavourable. Inflammatory mediators microRNAs (miRNAs) influence the aggressiveness of GBM, being involved in communication cells tumour parenchyma, including microglia/macrophages, maintaining an immunosuppressive microenvironment. Hence, modulation miRNAs inflammatory factors may improve...
The central nervous system (CNS) relies on complex and dynamic interactions between neurons glial cells. Among cells, astrocytes regulate the chemical environment surrounding supply essential nutrients for brain metabolism whereas microglia, resident macrophages of CNS, play critical roles in homeostasis, defense, responses to injury. Both microglia contribute regulation excitotoxicity inflammation mediated by tryptophan (Trp) via kynurenine pathway. Trp generates several bioactive...
In homeostasis, the glial cells support pivotal functions, such as neuronal differentiation, neuroprotection, nutrition, drug metabolism, and immune response in central nervous system (CNS). Among these cells, astrocytes microglia have been highlighted due to their role pathogenesis of several diseases or defense against insults (ex., chemicals, pathogens). Vitro cytological analysis has contributed understanding morphological changes associated with a neuroprotective neurotoxic phenotype....
Amburana cearensis is a plant native to Brazil used in folk medicine for the treatment of several pathological conditions including stroke. Previous research indicates that dichloromethane extract A. seeds (EDAC), rich coumarins, protects neural cells against oxygen and glucose deprivation (OGD) glutamate-induced stress. However, further studies are needed elucidate role coumarin, protective effect EDAC. Glutamatergic excitotoxicity an important cause neuronal loss involved pathogenesis...
Inflammation and oxidative stress are common aspects of most neurodegenerative diseases in the central nervous system. In this context, microglia astrocytes to mediating balance between neuroprotective neurodestructive mechanisms. Flavonoids have potent anti-inflammatory antioxidant properties. Here, we examined potential flavonoid agathisflavone (FAB), which is derived from Brazilian plant Poincianella pyramidalis, vitro models neuroinflammation. Cocultures neurons/glial cells were exposed...
Prosopis juliflora is a shrub largely used for animal and human consumption. However, ingestion has been shown to induce intoxication in animals, which characterized by neuromuscular alterations induced mechanisms that are not yet well understood. In this study, we investigated the cytotoxicity of total alkaloid extract (TAE) one fraction (F32) obtained from P. leaves rat cortical neurons glial cells. Nuclear magnetic resonance characterization F32 showed composed mixture two piperidine...
Recent evidence shows that aminochrome induces glial activation related to neuroinflammation. This dopamine derived molecule formation and stabilization of alpha-synuclein oligomers, mitochondria dysfunction, oxidative stress, dysfunction proteasomal lysosomal systems, endoplasmic reticulum stress disruption the microtubule network, but until now there has been no effects on production cytokines neurotrophic factors, are mechanisms involved in neuronal loss Parkinson's disease (PD). study...
This study aimed to investigate the antitumor and immunomodulatory properties of flavonoid apigenin (5,7,4'-trihydroxyflavone), which was extracted from Croton betulaster Mull, in glioma cell culture using high-proliferative rat C6 line as a model. Apigenin found have ability reduce viability proliferation cells time-dependent dose-dependent manner, with an IC50 22.8 µmol/l, 40 times lower than that temozolomide (1000 µmol/l), after 72 h treatment. Even were treated for 48 h, high...
Recent discoveries have shown that enteric glial cells play an important role in different neurodegenerative disorders, such as Parkinson’s disease (PD), which is characterized by motor dysfunctions caused the progressive loss of dopaminergic neurons substance nigra pars compacta and non-motor symptoms including gastrointestinal dysfunction. In this study, we investigated modulatory effects flavonoid rutin on behavior myenteric plexuses a PD animal model response glia. Adult male Wistar rats...
This study investigated the effects of flavonoids 5-hydroxy-7,4′-dimethoxyflavone, casticin, and penduletin, isolated from Croton betulaster Müll Arg., Euphorbiaceae, a plant utilized in popular medicine Brazil, on growth viability human glioblastoma cell line GL-15. We observed that 5-hydroxy-7,4′-dimethoxyflavone casticin were not toxic to GL-15 cells after 24 h exposure. However, penduletin inhibited metabolic activity significantly at concentration 10 μM (p ≤ 0.05). Flavonoids also...