A5002408123- Computational Drug Discovery Methods
- Research on Leishmaniasis Studies
- Cholinesterase and Neurodegenerative Diseases
- Trypanosoma species research and implications
- Malaria Research and Control
- Biofuel production and bioconversion
- Tuberculosis Research and Epidemiology
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and biological activity
- Insect and Pesticide Research
- Cocoa and Sweet Potato Agronomy
- Phytochemicals and Antioxidant Activities
- Insect Pest Control Strategies
- Carbohydrate Chemistry and Synthesis
- Bee Products Chemical Analysis
- Phytochemical compounds biological activities
- Antimicrobial agents and applications
- Analytical Chemistry and Chromatography
- Medicinal Plants and Neuroprotection
- Biological Research and Disease Studies
- Public Health in Brazil
- Enzyme function and inhibition
- Marine Sponges and Natural Products
- Plant-derived Lignans Synthesis and Bioactivity
- Tannin, Tannase and Anticancer Activities
Universidade Estadual de Feira de Santana
2013-2024
Federal University of São João del-Rei
2010
Tuberculosis (TB) is an infection caused by Mycobacterium tuberculosis, responsible for 1.5 million documented deaths in 2016. The increase reported cases of M. tuberculosis resistance to the main drugs show need development new and efficient better TB control. Based on these facts, this work aimed use combined silico techniques discovery potential inhibitors β-ketoacyl-ACP synthase (MtKasA). Initially compounds from natural sources present ZINC database were selected, then filters...
Myelin loss is the hallmark of demyelinating disease multiple sclerosis (MS) and plays a significant role in neurodegenerative diseases. A common factor all neuropathologies central microglia, intrinsic immune cells nervous system (CNS). Microglia are activated pathology can have both pro- anti-inflammatory functions. Here, we examined effects flavonoid agathisflavone on microglia remyelination cerebellar slice model following lysolecithin induced demyelination. Notably, enhances alters...
Abstract Introduction Lauraceae alkaloids are a structurally diverse class of plant specialised secondary metabolites that play an important role in modern pharmacotherapy, being useful as well model compounds for the development synthetic analogues. However, characterisation is challenging due to low concentrations, complexity extracts, and long processes accurate structural determinations. Objective The use high‐performance thin layer chromatography coupled with desorption electrospray...
The blood-brain barrier (BBB) is known to protect healthy brain cells from potentially dangerous chemical agents, but there are many evidences supporting the idea that this protective action extended tumor cells. Since process of angiogenesis in tumors leads BBB breakdown, biochemical characteristics seem be more relevant than physical barriers chemotherapy. In fact, a number resistance related factors were already demonstrated component both and enzyme glutathione S-transferases (GST)...
Rhipicephalus microplus is an important ectoparasite of cattle, causing considerable economical losses. Resistance to chemical acaricides has stimulated the search for new antiparasitic drugs, including natural products as eco-friendly alternative control. Flavonoids represent a class compounds with many biological activities, such enzyme inhibitors. Acetylcholinesterase essential tick survival that stands out target development acaricides. This work aimed predict this 3D structure by...
Abstract Neglected Tropical Diseases are a significant concern as they encompass various infections caused by pathogens prevalent in tropical regions. The limited and often highly toxic treatment options for these diseases necessitate the exploration of new therapeutic candidates. In present study, lignan methylpiperitol was isolated after several chromatographic steps from Persea fulva L. E. Koop (Lauraceae) its leishmanicidal trypanocidal activities were evaluated using vitro silico...
The molecular mechanisms underlying the observed anticancer effects of flavonoids remain unclear. Increasing evidence shows that aryl hydrocarbon receptor (AHR) plays a crucial role in neoplastic disease progression, establishing it as potential drug target. This study evaluated hydroxy flavonoids, known for their properties, to interact with AHR, both silico and vitro, aiming understand action identify selective AHR modulators. A PAS-B domain homology model was constructed evaluate...
The enzyme UDP-N-acetylglucosamine pyrophosphorylase (PyroMp) from Moniliophthora perniciosa (CCMB 0257), a pathogenic fungal strain and the causative agent of witches' broom disease in Theobroma cacao, was partially purified by precipitation with ammonium sulfate gel filtration on Sephacryl S-200. buffer for extraction sodium phosphate, 0.050 mol L-1, pH 7.0, containing 1.0 L-1 NaCl. Response surface methodology (RSM) used to determine optimum temperature conditions. Four different...
The witches' broom disease is a plague caused by Moniliophthora perniciosa in the Theobroma cacao, which has been reducing cocoa production since 1989. This issue motivated genome project that showing several new molecular targets, can be developed inhibitors order to control plague. Among targets obtained, UDP-N-acetylglucosamine pyrophosphorylase (UNAcP) key enzyme construct fungal cell wall. inhibition of this results death.
Visceral leishmaniasis (VL) is the second most important vector-borne disease in world. It transmitted by Lutzomyia longipalpis America; therefore, controlling vector essential to prevent disease, especially using traps with chemical attractants. known that odorant binding proteins (OBPs) act at first odor selection level, so silico methodology was used identify putative modulators based on OBPs ligand structures. Therefore, 3D structures of L. OBP were predicted through different...
Honey is a food of nutritional, medicinal and commercial importance. The physicochemical characteristics, pollen spectrum mineral composition eighteen honey samples obtained from regions (Cachoeira, Coqueiros, Maragojipe Santiago do Iguape) near the Paraguaçu River, Bahia, Brazil were evaluated. Botanical families Asteraceae, Leguminosae, Malvaceae, Myrtaceae Palmae most frequently found. Five had water contents above maximum limit established by Brazilian legislation (> 20%). was determined...
Abstract The Witches' Broom Disease, caused by the hemibiotrophic basidiomycete fungus Moniliophthora perniciosa , drastically reduced production of cocoa in Brazil. Phytosanitation, chemical control, genetically resistant strains, and biological control still leave flaws disease eradication process. Effort has been expended elucidation molecular targets, particular, structural components fungal cell wall, such as beta(1,3)‐ D ‐glucan synthase. This enzyme is essential for cellular...
Objetivo: avaliar o perfil das potenciais interações medicamentosas da Unidade de Terapia Intensiva Neonatal (UTI-Neo) um hospital público infantil do interior Bahia. Métodos: Foi realizado estudo descritivo, com delineamento transversal. Foram coletadas e analisadas as prescrições médicas (PM) impressas UTI neonatal no período 01 maio 2016 a 31 outubro 2016. incluídas somente PM contendo identificação dos pacientes, data, assinatura carimbo prescritor que possuíam dois ou mais fármacos. Os...
Moniliophthora perniciosa (Sthael) (Singer) Phillips-Mora is the causal agent of witches' broom disease, which can infect Theobroma cacao decreasing production cocoa about 60%. M. has a set potential enzymes that be useful targets for design new inhibitors. After release aminoacid sequence pyrophosphorylase perniciosa, comparative modelling approach was carried out to obtain 3D structure this target. This model develop inhibitors against disease.
Abstract Artemisinin is a sesquiterpene lactone with an endoperoxide function that currently being used against strains of Plasmodium falciparum . Endoperoxides are supposed to act on heme leading reduction the peroxide bond and production radicals can kill parasite. As artemisinin, other natural compounds have group may also show antimalarial activity. This fact motivated us study interaction 18 peroxides Brazilian flora compared values obtained for artemisinin. Initially, conformational...
O Diabetes mellitus do tipo 2 (DM-2) é uma desordem metabólica que apresenta a hiperglicemia como característica principal, caracterizado pela resistência à ação da insulina e disfunção das células ? pancreáticas. Este trabalho objetivou apresentar farmacoterapia os avanços no tratamento DM-2. A metodologia empregada foi pesquisa bibliográfica. DM-2 multifatorial incluindo, primeiramente, educação mudanças estilo de vida e, posteriormente intervenção farmacológica. Os antidiabéticos orais...
Premature infants have an immature intestinal microbiota when compared to a full-term baby, colonized with reduced number of beneficial bacterial species and, therefore, are more likely their populated by pathogenic species. The administration probiotics can positively influence the colonization premature babies. Thus, this study aimed systematically review evidences effect administering on newborns and safety. It was designed as follows: population (premature newborns), intervention...