A5100677810- Microbial Metabolic Engineering and Bioproduction
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Microbial bioremediation and biosurfactants
- Biofuel production and bioconversion
- Drug-Induced Hepatotoxicity and Protection
- Plant Toxicity and Pharmacological Properties
- Membrane Separation Technologies
- Biochemical and biochemical processes
- Anaerobic Digestion and Biogas Production
- HIV, Drug Use, Sexual Risk
- Oral microbiology and periodontitis research
- Dental Anxiety and Anesthesia Techniques
- Endodontics and Root Canal Treatments
- Smart Cities and Technologies
- Foreign Body Medical Cases
- Genomics, phytochemicals, and oxidative stress
- Ocular Disorders and Treatments
- Employer Branding and e-HRM
- Cancer Mechanisms and Therapy
- Microbial metabolism and enzyme function
- Chromatin Remodeling and Cancer
- Methane Hydrates and Related Phenomena
- Microbial Metabolism and Applications
- Job Satisfaction and Organizational Behavior
Hospital Beatriz Ângelo
2022-2025
University of Coimbra
2024
University of Minho
2016-2022
Hospital de Base
2020
Hospital de Santa Maria
2003-2018
Stemmatters (Portugal)
2017
Institute for Biotechnology and Bioengineering
2017
National Institute of Health Dr. Ricardo Jorge
2017
Universidade do Porto
2017
University of Lisbon
2017
Abstract In recent years microorganisms have been engineered towards synthesizing interesting plant polyphenols such as flavonoids and stilbenes from glucose. Currently, the low endogenous supply of malonyl‐CoA, indispensable for polyphenol synthesis, impedes high product titers. Usually, limited malonyl‐CoA availability during production is avoided by supplementing fatty acid synthesis‐inhibiting antibiotics cerulenin, which are known to increase intracellular pool a side effect. Motivated...
Liver cirrhosis (LC) is a heterogeneous liver disease, the last stage of fibrosis, and major risk factor for hepatocellular carcinoma (HCC). Our study aimed to evaluate expression microRNAs endothelial vascular growth (VEGFA) gene in LC HCC.The sample group consisted 46 tissue samples: 21 LC, 15 HCC, 10 non-tumoural non-cirrhotic (control group). MiRNAs were chosen based on mirDIP prediction database as regulators VEGFA gene. Gene VEGF miRNAs was quantified by real-time quantitative...
A Síndrome de Boerhaave, uma condição rara e frequentemente fatal, foi descrita pela primeira vez em 1724 representa cerca 15% das perfurações esofágicas. Está associada a aumentos pressão intraluminal após episódios vigorosos vômito. Os desafios diagnósticos são significativos, com tríade clássica Mackler presente menos 50% dos casos. O diagnóstico precoce é crucial, pois o atraso no tratamento eleva mortalidade para mais 40%. Neste artigo, relatamos caso um paciente admitido por intensa...
Edible berries are considered to be among nature's treasure chests as they contain a large number of (poly)phenols with potentially health-promoting properties. However, complex (poly)phenol mixtures, it is challenging associate any interesting pharmacological activity single compound. Thus, identification pharmacologically phenols requires systematic analyses berry extracts. Here, raspberry (Rubusidaeus, var Prestige) extracts were systematically analyzed identify bioactive compounds...
Introduction HIV late presentation (LP) remains excessive in Europe. We aimed to analyze the factors associated with MSM population newly diagnosed Portugal between 2014 and 2019. Methods included 391 HIV-1 Men who have Sex (MSM), from BESTHOPE project, 17 countrywide Portuguese hospitals. The data clinical socio-behavioral questionnaires viral genomic sequence obtained drug resistance test before starting antiretrovirals (ARVs). subtypes epidemiological surveillance mutations were...
Seaweeds have been utilized for millennia in Asian countries, although they only more recently become popular Western society. They began to be used ancient times because of their long-term properties and, nowadays, seaweeds are being targeted as a potential tool combat climate change. There not many laws governing just lately food. However, guidelines developed regulate manufacture and use. Because seaweed’s tendency accumulate components, whether helpful or poisonous, limited doses certain...
Abstract Thermophilic biohydrogen production by dark fermentation from a mixture (1:1) of C5 (arabinose) and C6 (glucose) sugars, present in lignocellulosic hydrolysates, Sargassum sp . biomass, is studied this work batch assays also continuous reactor experiment. Pursuing the interest studying interactions between inorganic materials (adsorbents, conductive others) anaerobic bacteria, biological processes were amended with variable amounts zeolite type-13X range zeolite/inoculum (in VS)...
Purpose: To analyze changes in wettability of hydrogel and silicone contact lenses (CLs) when preserved different lens care systems. Methods: In this research, four CLs (senofilcon A, balafilcon comfilcon lotrafilcon B) one conventional CL (etafilcon A) appropriate solutions (ReNu MultiPlus, Biotrue, OPTI-FREE PureMoist, AOSept Plus) were used. Lenses immersed each system for 12 hr then hydrophobicity was determined through water angle (CA) measurements using the OCA 20 instrument...
Abstract BACKGROUND The growing interest in polyphenols has led to the design of industrial‐scale processes able produce them by fermentation and recover a more sustainable way. goal this work is present two integrated approaches for recovery resveratrol, obtained through fermentation. production resveratrol using Corynebacterium glutamicum its continuous removal hydrophobic resin described. Batch compared with situ product removal, where Amberlite XAD‐7HP either directly added medium...
It is known that the exposure to benzene in petroleum industry causes lympho-haematopoietic cancer among workers. However, there little data concerning toxicity of central nervous system. Benzene easily penetrates brain where it metabolized catechol. Since catechol autoxidizes physiological phosphate buffer, we hypothesized could be toxic towards glial cells due generation reactive oxygen species and quinones. In this work studied cytotoxic properties human glioblastoma cells. We found was...
To describe and analyze transmitted drug resistance (TDR) between 2014 2019 in newly infected patients with HIV-1 Portugal to characterize its transmission networks.Clinical, socioepidemiological, risk behavior data were collected from 820 diagnosed September December 2019. The sequences obtained testing used for subtyping, TDR determination, cluster (TC) analyses.In Portugal, the overall prevalence of was 11.0%. presented a decreasing trend 16.7% 9.2% 2016 (p for-trend = 0.114)....
This article presents proteomics data referenced in [1] Using proteomics-based evaluation of red blood cells (RBCs), we have identified differentially abundant proteins associated with Obstructive Sleep Apnea Syndrome (OSA). RBCs were collected from peripheral patients moderate/severe OSA or snoring at pre- (evening) and post-night (morning) polysomnography, so that proteome variations between these time points could be assessed. RBC cytoplasmic fraction depleted hemoglobin, using Hemovoid™...
ABSTRACT The present study aims to evaluate the antimicrobial effect of two new intracanal preparations against E. faecalis. Thirty single-rooted human canine teeth were used. crowns removed and roots instrumented using a conventional technique. Three groups ten each infected with 108 CFU/ ml faecalis for 21 days. root canals filled medications containing 3% doxycycline hydrochloride (DX) or 2% chlorhexidine digluconate (CHX). Ten received no medication (NM)-negative control. Microbial...
Biosorbent materials are effective in the removal of spilled oil from water, but their effect on hydrocarbonoclastic bacteria is not known. Here, we show that corksorb, a cork-based biosorbent, enhances growth and alkane degradation by Rhodococcus opacus B4 (Ro) Alcanivorax borkumensis SK2 (Ab). Ro Ab degraded 96 ± 1% 72 2%, respectively, mixture n-alkanes (2 g L-1) presence corksorb. These values represent an increase 6 24%, relative to assays without The biosorbent also increased 51%....
The diet and feeding behaviour of the forkbeard Phycis phycis was studied based on 246 stomachs collected between May 2011 April 2012 from a commercial fleet operating off central west coast Portugal. A total 44 prey items were identified in which merged into major groups to avoid problems with low expected frequencies. following taxonomic categories considered: non-decapod Crustacea, Caridea, Anomura, Munida spp., Processa Brachyura, Pisces, Trisopterus luscus . In order investigate...