A5040951375- HIV/AIDS Research and Interventions
- Mosquito-borne diseases and control
- HIV Research and Treatment
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- Blood groups and transfusion
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Blood donation and transfusion practices
- HIV, Drug Use, Sexual Risk
- COVID-19 Impact on Reproduction
- Blood Pressure and Hypertension Studies
- COVID-19 and Mental Health
- Iron Metabolism and Disorders
- HIV/AIDS Impact and Responses
- Hepatitis B Virus Studies
- HIV-related health complications and treatments
- Hemoglobinopathies and Related Disorders
- Diabetes and associated disorders
- Erythrocyte Function and Pathophysiology
- Hepatitis C virus research
- Immune responses and vaccinations
- Pneumocystis jirovecii pneumonia detection and treatment
Universidade Nova de Lisboa
2019-2025
University of Lisbon
2021-2025
Clínica Sagrada Esperança
2023-2024
Agostinho Neto University
2018-2024
Instituto de Saúde
2024
Instituto de Investigação Científica Tropical
2023
Instituto Nacional de Saúde
2022-2023
Ministry of Health
2019-2022
Universidad San Francisco de Quito
2019
University of KwaZulu-Natal
2019
Zika virus infections and suspected microcephaly cases have been reported in Angola since late 2016, but no data are available about the origins, epidemiology, diversity of virus. We aimed to investigate emergence circulation Angola.Diagnostic samples collected by Angolan Ministry Health as part routine arboviral surveillance were tested real-time reverse transcription PCR Instituto Nacional de Investigação em Saúde (Ministry Health, Luanda, Angola). To identify further positive for...
Abstract We used portable genome sequencing to investigate reported dengue virus transmission in Angola. Our results show that autochthonous of serotype 2 (cosmopolitan genotype) occurred January 2018.
Background The transmission patterns and genetic diversity of dengue virus (DENV) circulating in Africa remain poorly understood. Circulation the DENV serotype 1 (DENV1) Angola was detected 2013, while 2 (DENV2) 2018. Here, we report results from molecular genomic investigations conducted at Ministry Health national reference laboratory (INIS) on suspected cases between January 2017 February 2019. Methods A total 401 serum samples were collected 13 18 provinces Angola. Of those, 351 had...
HIV-2 affects over 1 million people globally and can lead to AIDS if untreated. Treating living with (PLHIV-2) is challenging because the virus inherently resistant some drugs. Effective treatment monitoring, particularly drug resistance testing, critical for managing therapeutic failure. Without commercial tests identify mutations (DRM), laboratories have felt need develop in-house methods. NGS provides improved sensitivity detecting minority DRM, which crucial effectively treating...
ABSTRACT Multidrug‐resistant HIV patients have limited ART options. Lenacapavir (LEN) is a capsid inhibitor that exhibits substantial antiviral activity in with therapeutic failure but also proposed for PrEP. Herein, we assessed LEN susceptibility among ART‐naive drug resistance Mozambique. In this study, 63 DRM against PIs, NRTIs, NNRTIs, and INSTIs were included. The gag (p24) env fragments amplified low‐cost in‐house protocol sequenced nanopore. HIVDR database from Stanford University was...
Abstract Sexually transmitted infections (STIs) are a global health concern. Blood donation centres employ comprehensive screening measures to identify donors with STIs, such as HIV, HBV, HCV, and syphilis, which can also through blood transfusions. Herein, we investigated the seroprevalence of STIs demographic determinants related multiple among rejected at National Transfusion Service (NBTS) in Angola. This was cross-sectional study conducted 1885 serologically screened for anti-HBsAg,...
ABSTRACT Background and Aims Asthma is the most common chronic non‐communicable disease in children with a higher prevalence high‐income countries, however, majority of asthma‐related deaths occur low‐ middle‐income including Angola. Therefore, we aimed to investigate asthma allergic diseases among schoolchildren Huambo, Angola's fourth populous province. Methods A cross‐sectional study was carried out April May 2022 aged 6–14 using ISAAC methodology. The questionnaire included questions on...
Co-epidemics happening simultaneously can generate a burden on healthcare systems. The co-occurrence of SARS-CoV-2 with vector-borne diseases (VBD), such as malaria and dengue in resource-limited settings represents an additional challenge to the Herein, we assessed coinfection rate between VBD highlight need carry out accurate diagnosis promote timely measures for these infections Luanda, capital city Angola. This was cross-sectional study conducted 105 subjects tested rapid detection test...
Background Despite the guidelines provided by World Health Organization for treatment of malaria, failure occurs in many hospitalized patients. Objective Evaluate whether blood cell count parameters may serve as predictors malaria treatment. Methodology A cross-sectional study with a quantitative approach. Results Of 219 patients, 21.5% showed to antimalarial treatment, Patient 21 and 40 years (72.6%), male (53.4%), from peri-urban area (47.5%), high parasitemia (59.8%), treated Arthemeter...
Abstract The surveillance of drug resistance in the HIV-1 naïve population remains critical to optimizing effectiveness antiretroviral therapy (ART), mainly era integrase strand transfer inhibitor (INSTI) regimens. Currently, there is no data regarding INSTI Angola since Dolutegravir-DTG was included first-line ART regimen. Herein, we investigated genetic diversity and pretreatment (PDR) profile against nucleoside/tide reverse transcriptase inhibitors (NRTIs), non-nucleoside (NNRTIs),...
Hypertension is a public health concern, mainly in resource-limited countries. We investigated the characteristics and risk factors related to high blood pressure healthy donors from, Luanda, capital city of Angola.
This study aimed to investigate the characteristics related SARS-CoV-2 in Luanda, Angola. A total of 622 individuals were screened for from January September 2020. Chi-square and logistic regression used identify relationship between sociodemographic SARS-CoV-2. Of tested, 14.3% tested positive. The infection rate was same both genders (14.3%). Individuals ≥40 years old, non-urbanized areas, healthcare professionals had a higher frequency infection. risk very high ≥60 old (AOR: 23.3, 95% CI:...
Background: The global scale-up of antiretroviral treatment (ART) offers significant health benefits by suppressing HIV-1 replication and increasing CD4 cell counts. However, incomplete viral suppression poses a potential threat for the emergence drug resistance mutations (DRMs), limiting ART options, HIV transmission. Objective: We investigated patterns transmitted (TDR) acquired (ADR) among patients in Portugal. Methods: Data were obtained from 1050 patient samples submitted (HIVDR)...
Background Molecular epidemiology techniques allow us to track the HIV-1 transmission dynamics. Herein, we combined genetic, clinical and epidemiological data collected during routine treatment evaluate dynamics characteristics of clusters most prevalent subtypes in state São Paulo, Brazil. Methods This was a cross-sectional study conducted with 2,518 persons living HIV (PLWH) from 53 cities Paulo between Jan 2004 Feb 2015. The phylogenetic tree protease/reverse transcriptase (PR/RT) regions...
HIV-1 infections remain a global public health concern. Scaled-up antiretroviral treatment (ART) is crucial for reducing morbidity and mortality related to HIV/AIDS. The emergence of drug-resistance mutations (DRMs) compromises viral suppression contributes the continued transmission. Several reports indicate recent increase in acquired (ADR) transmitted (TDR) drug resistance Africa, probably linked lack implementation HIV (HIVDR) testing suboptimal adherence. Herein, we will develop...
Acute kidney injury (AKI) is a common complication of malaria. In low resource settings, lack diagnostic tools and delayed treatment malaria associated AKI lead to significant morbidity mortality. The aim this study was assess the performance salivary urea nitrogen (SUN) dipstick detect monitor disease [KD = or acute (AKD) without AKI] in patients Angola.Patients 11-50 years old admitted with at Josina Machel (Maria-Pia) Hospital, Luanda, Angola, between 2nd March 10th May 2016 were enrolled...
Abstract Infectious diseases during pregnancy remain a public health concern, especially in resource‐limited setting. The study aimed to determine the seroprevalence and determinants of HIV co‐infection with hepatitis B virus (HBV), C (HCV), syphilis among pregnant women attending antenatal care Luanda, capital city Angola. A cross‐sectional was conducted 1612 screened for care. HIV‐reactive were also HBV, HCV, using immunoassay kits. logistic regression model, adjusted odds ratios (AOR)...
The dissemination of the dengue virus (DENV) in endemic regions with HIV is a public health concern greater importance when there evidence vertical transmission DENV during pregnancy. Herein, we investigated among HIV-infected pregnant women Luanda, capital city Angola. This was part cross-sectional study carried out on 42 newly diagnosed HIV. A total 36 plasma samples from HIV-positive were screened for using RT‐PCR and ELISA. None specimens tested positive by RT-PCR. Regarding...
SARS-CoV-2 emerged in China and spread throughout the world due to its rapid transmission. The exposure rate healthy population is unknown, mainly resource-limited countries. Herein, we estimated seroprevalence of anti-SARS-CoV-2 antibodies risk factors among blood donors Luanda, capital city Angola.This was a retrospective study conducted with 343 donors. Chi-square logistic regression were calculated predict independent variable for infection deemed significant when p < 0.05.Seroprevalence...
SARS-CoV-2 infection is a public health concern. Several aspects related to the pattern of remain unclear. This study aimed investigate blood pressure among donors exposed in Luanda, Angola, sub-Saharan African country.We performed retrospective analysis containing 343 from December 2019 September 2020. Parametric tests compared means while χ2 and logistic regression checked features associated with high were considered significant when p < 0.05.The mean age was 32.2 ± 8.81 years (ranging 18...
Monitoring genetic diversity and drug resistance mutations (DRMs) is critical for understanding HIV epidemiology. Here, we report HIV-1 DRMs in blood samples from 42 HIV-positive pregnant women naive to antiretroviral therapy (ART), Luanda. The were subjected nested-PCR, followed by sequencing of pol gene, targeting the protease reverse transcriptase fragments. was analyzed using REGA subtyping tool identified Calibrated Population Resistance tool. A total 34 sequences obtained. data...
The incidence of Acute Kidney Injury (AKI) due malaria has increased and in low middle-income countries with negative impact the death hospitalization. aim this study was to evaluate AKI effects parasitemia levels kidney function patients hospitalized Josina Machel hospital from March May 2016. A longitudinal, prospective observational performed 135 during period. Patients were followed-up monitored by measurements serum creatinine (SCr) Blood Urea Nitrogen (SUr) for a period between 2 4...