A5059653767- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Infectious Diseases and Tuberculosis
- Mycobacterium research and diagnosis
- Immune responses and vaccinations
- Antibiotic Resistance in Bacteria
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Lipids, and Metabolism
- Zoonotic diseases and public health
- Blood donation and transfusion practices
- Cancer Genomics and Diagnostics
- Immune Response and Inflammation
- Malaria Research and Control
- Genetic factors in colorectal cancer
- Viral Infections and Vectors
- Lung Cancer Treatments and Mutations
- Antibiotics Pharmacokinetics and Efficacy
- Vaccine Coverage and Hesitancy
- Iron Metabolism and Disorders
- Diagnosis and treatment of tuberculosis
- Blood Pressure and Hypertension Studies
National Institute for Health Research
2023
Agostinho Neto University
2022-2023
Instituto Nacional de Saúde
2022-2023
Sun Yat-sen University
2017-2020
Fifth Affiliated Hospital of Sun Yat-sen University
2018-2020
Guangzhou Medical University
2018
Guangzhou Women and Children Medical Center
2018
University of Cape Town
2014-2017
Radical new possibilities of improved treatment cancer are on offer from an advanced medical technology already demonstrating its significance: next-generation sequencing (NGS). This refined testing provides unprecedentedly precise diagnoses and permits the use focused highly personalized treatments. However, across regions globally, many patients will continue to be denied benefits NGS as long some yawning gaps in implementation remain unattended. The challenges at regional national levels...
The SARS-CoV-2 genome occupies a unique place in infection biology - it is the most highly sequenced on earth (making up over 20% of public sequencing datasets) with fine scale information sampling date and geography, has been subject to unprecedented intense analysis. As result, these phylogenetic data are an incredibly valuable resource for science health. However, vast majority was by tiling amplicons across full genome, amplicon schemes that changed pandemic as mutations viral interacted...
In a longitudinal study in first-level hospital Luanda, Angola, we found rifampin-resistant and multidrug-resistant tuberculosis (TB) 38 (8%, 95% CI 5.7-10.8) of 474 patients with no previous history TB. Of note, 2 (0.4%, 0.1-1.5) demonstrated pre-extensively drug-resistant
Tuberculosis (TB) affects one third of the global population, and TB central nervous system (CNS-TB) is most severe form tuberculosis which often associates with high mortality. The pro-inflammatory cytokine tumour necrosis factor (TNF) plays a critical role in initial long-term host immune protection against Mycobacterium (M. tuberculosis) involves activation innate cells structure maintenance granulomas. However, contribution TNF, particular neuron-derived control cerebral M. infection its...
Beta-defensins 2 and 3 (BD2 BD3) are inducible peptides present at the sites of infection, they well characterized for their antimicrobial activities immune-regulatory functions. However, no study has thoroughly investigated immunomodulatory effects on macrophage-mediated immune responses against Pseudomonas aeruginosa (PA). Here, we demonstrate that BD2 BD3 suppressed macrophage autophagy but enhanced engulfment PA Zymosan bioparticles as formation phagolysosomes, using immunofluorescence...
Background Despite the guidelines provided by World Health Organization for treatment of malaria, failure occurs in many hospitalized patients. Objective Evaluate whether blood cell count parameters may serve as predictors malaria treatment. Methodology A cross-sectional study with a quantitative approach. Results Of 219 patients, 21.5% showed to antimalarial treatment, Patient 21 and 40 years (72.6%), male (53.4%), from peri-urban area (47.5%), high parasitemia (59.8%), treated Arthemeter...
Abstract The surveillance of drug resistance in the HIV-1 naïve population remains critical to optimizing effectiveness antiretroviral therapy (ART), mainly era integrase strand transfer inhibitor (INSTI) regimens. Currently, there is no data regarding INSTI Angola since Dolutegravir-DTG was included first-line ART regimen. Herein, we investigated genetic diversity and pretreatment (PDR) profile against nucleoside/tide reverse transcriptase inhibitors (NRTIs), non-nucleoside (NNRTIs),...
Abstract Background and Aims The acute tropical infectious disease known as yellow fever (YF) is caused by an arbovirus characterized fever, jaundice, hemorrhage, headache, muscle pain, nausea, vomiting, fatigue. Angola experienced a virus (YFV) outbreak that was documented in December 2015. However, little about the outcome of this outbreak. We aimed to demonstrate epidemic features lessons learned during YF Angola. Methods A total 4618 blood samples from suspected cases were sent Instituto...
Since 2015, plasmid-borne
Hypertension is a public health concern, mainly in resource-limited countries. We investigated the characteristics and risk factors related to high blood pressure healthy donors from, Luanda, capital city of Angola.
Abstract Triggering receptor expressed on myeloid cells 1 (TREM-1) is a mainly cells, and it plays an important role in modulating immune response against infectious agents. The function of TREM-1 nonmyeloid such as Vδ2 T has not been characterized, their pulmonary tuberculosis (TB) remains unclear. To assess the expression blood from TB patients investigate its mechanism induction, we exploited flow cytometry analysis to study active control subjects. In this demonstrate that (TREM-1+)...
ABSTRACT Mycobacterium tuberculosis infection of the central nervous system is thought to be initiated once bacilli have breached blood brain barrier and are phagocytosed, primarily by microglial cells. In this study, interactions M. with neurons in vitro vivo were investigated. The data obtained demonstrate that can act as host cells for . internalized murine neuronal cultured a time-dependent manner after exposure, superior uptake HT22 compared Neuro-2a (17.7% versus 9.8%). Internalization...
We investigated the clonal diversity of carbapenemase-producing Klebsiella pneumoniae isolates from Shenzhen Children's Hospital, China, and drew conclusions on clinical public health impact these as multidrug-resistant.From January 2014 to December 2018, a total number 36 unique were collected out 900 in paediatric patients China. After carbapenemase production confirmation, antimicrobial susceptibility, resistance determinants phylogenetic relationship determined.The showed ceftazidime,...
SARS-CoV-2 infection is a public health concern. Several aspects related to the pattern of remain unclear. This study aimed investigate blood pressure among donors exposed in Luanda, Angola, sub-Saharan African country.We performed retrospective analysis containing 343 from December 2019 September 2020. Parametric tests compared means while χ2 and logistic regression checked features associated with high were considered significant when p < 0.05.The mean age was 32.2 ± 8.81 years (ranging 18...
Tackling cancer is a major challenge right on the global level. Europe only tip of an iceberg around world. Prosperous developed countries share same problems besetting Europe-and and regions with fewer resources less propitious conditions are in many cases struggling often heroically against growing tide disease. This paper offers view these geographically wider, but essentially similar, challenges, prospects for barriers to better results this ceaseless battle. A series panels have been...
Emergence of plasmid-born mobile colistin resistance (mcr) gene, a growing concern in healthcare. Therefore, this study aims to genomically characterize multidrug-resistant Escherichia coli and Klebsiella pneumoniae co-harboring the mcr-1 mcr-3 genes young children. E. (n=3) K. (n=2) were collected from abdominal secretion blood, respectively. The isolates screened using tryptone soya broth (TSB) with 4µl/ml polymyxin-B. Growing bacteria identified VITEK-2 system, MALDI-TOF 16s RNA...
The global emergence of coronavirus disease 2019 (COVID-19) has challenged healthcare and rapidly spread over the globe. Early detection new infections is crucial in control emerging diseases. Evidence early recorded COVID-19 cases outside China been documented various countries. In this study, we aimed to identify time SARS-CoV-2 infection circulation by retrospectively analyzing sera measles patients, weeks before reported first Angola.We examined humoral response against using an...
Tuberculosis of the central nervous system (CNS-TB) is a devastating complication tuberculosis, and tumour necrosis factor (TNF) crucial for innate immunity controlling infection. TNF produced by many cell types upon activation, in particularly myeloid T cells during neuroinflammation. Here we used mice with ablation targeted to (MT-TNF-/-) assess contribution derived immune responses CNS-TB. These exhibited impaired high susceptibility cerebral M. tuberculosis infection, similar phenotype...
Tuberculosis (TB) is a major cause of illness and public health concern, especially in resource-limited countries. This study analyzed the characteristics related to anti-TB drug resistance. Moreover, we examined evidence-based indications for treatment active TB Angola. evaluated medical records 176 patients screened from January September 2016 Luanda, capital city Approximately 66.5% were newly diagnosed with TB. The residence area showed significant relationship (P = 0.025), whereas age...
Background: This ethnobotanical study is the first based on herbal teas or tisanes consumed in Angola, specifically Uíge province. The aims of this were to document traditional knowledge related use and then assess their floristic diversity. Methods: Field research was conducted between January December 2022, both rural urban areas Ethnobotanical methods included participatory observation, semi-structured interviews, key informant focus group discussions. These used obtain detailed...