A5101656517- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Cancer-related molecular mechanisms research
- Hydrogels: synthesis, properties, applications
- Bacterial biofilms and quorum sensing
- Enterobacteriaceae and Cronobacter Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Vibrio bacteria research studies
- Antibiotic Use and Resistance
- Ferroptosis and cancer prognosis
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Bone health and treatments
- Nanoplatforms for cancer theranostics
- Urinary Tract Infections Management
- Esophageal and GI Pathology
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Aerogels and thermal insulation
- Berberine and alkaloids research
- Epigenetics and DNA Methylation
- Infections and bacterial resistance
- Silk-based biomaterials and applications
- Tuberculosis Research and Epidemiology
- bioluminescence and chemiluminescence research
State Key Laboratory of Polymer Physics and Chemistry
2009-2025
Chinese Academy of Sciences
2009-2025
Institute of Chemistry
2009-2025
Beijing National Laboratory for Molecular Sciences
2025
Chongqing Medical University
2019-2024
Kunming Medical University
2021-2024
First Affiliated Hospital of Kunming Medical University
2021-2024
Nanjing Forestry University
2022
Jiamusi University
2009-2022
First Affiliated Hospital of Jiamusi University
2009-2022
Abstract Novel double‐network (DN) hydrogels with high mechanical strength have been fabricated two biocompatible polymers, poly(vinyl alcohol) (PVA) and poly(ethylene glycol) (PEG), through a simple freezing thawing method. Some properties of the obtained hydrogels, such as strength, rheological thermodynamic behavior, drug release, morphology, characterized. The results reveal that in sharp contrast to most common made natural or synthetic PVA/PEG can sustain compressive pressure several...
Background Due to the critical condition and poor immunity of patients, intensive care unit (ICU) has always been main hospital source multidrug-resistant bacteria. In recent years, with large-scale use antibiotics, detection rate mortality carbapenem-resistant Klebsiella pneumoniae (CRKP) have gradually increased. This study explores molecular characteristics prevalence CRKP isolated from ICU ward a tertiary in China. Methods A total 51 non-duplicated samples were collected July 2018–July...
Hepatocellular carcinoma (HCC) is characterized by aggressive progression and elevated mortality rates. This study aimed to investigate the regulatory effects of RBBP7 on HCC pathogenesis underlying mechanisms. The expression clinical feature were evaluated using bioinformatics analysis assessment samples. CCK8 colony formation employed estimate cell proliferation function RBBP7. Aerobic glycolysis levels measuring ATP levels, lactic acid production, glucose uptake capacity, relevant enzymes...
The fabrication of nanostructures from polycyclic aromatic hydrocarbons (PAHs) is highly attractive owing to their unique optical, electrical, and magnetic properties. However, the creation uniform well-defined PAH by self-assembly still remains a significant challenge. Herein, we report that hexagonal rods can be obtained triphenylene (TP)-derived monomers synchronized polymerization (SPSA). These have single-domain columnar liquid crystalline structure in which columns formed stacked TPs...
The emergence of multi-drug-resistant Gram-negative bacteria (GNB) is a concern in China and globally. This study investigated antimicrobial resistance traits determinant detection GNB isolates from paediatric patients China.In the present study, total 170 including most prevalent Escherichia coli, Klebsiella pneumoniae Acinetobacter baumannii were collected Shenzhen Children's Hospital, China. ESBLs production was confirmed by using combination disc diffusion method, carbapenemase...
Background This study aimed to determine the molecular characteristics of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates in a hospital western Chongqing, southwestern China. Methods A total 127 unique CRKP were collected from Yongchuan Hospital Chongqing Medical University, identified using VITEK-2 compact system, and subjected microbroth dilution minimal inhibitory concentration. Enterobacteriaceae intergenic repeat consensus polymerase chain reaction multilocus sequence typing...
To investigate the activity of 5 antibiotic monotherapies, including colistin (COL), meropenem (MEM), amikacin (AMK), levofloxacin (LEV), and tigecycline (TGC), when combined with 4 other antibiotics against clinical isolates carbapenem-resistant Klebsiella pneumoniae (CRKP) in vitro.The minimum inhibitory concentrations (MICs) 40 CRKP were determined by micro-broth dilution method. There synergistic effects between TGC combinations 10 detected checkerboard microdilution Time-kill assay was...
We investigated the clonal diversity of carbapenemase-producing Klebsiella pneumoniae isolates from Shenzhen Children's Hospital, China, and drew conclusions on clinical public health impact these as multidrug-resistant.From January 2014 to December 2018, a total number 36 unique were collected out 900 in paediatric patients China. After carbapenemase production confirmation, antimicrobial susceptibility, resistance determinants phylogenetic relationship determined.The showed ceftazidime,...
The mechanistic basis for relapsed hepatocellular carcinoma (HCC) remains poorly understood. Recent research has highlighted the important roles of long non-coding RNAs (lncRNAs) in HCC. However, there are only a few studies on association between lncRNAs and HCC relapse. Differentially expressed mRNAs primary group were identified using edge R package to analyze GSE101432 dataset. differentially used construct lncRNA-mRNA co-expression network. Weighted gene network analysis followed by...
Background: The aim of this study was to investigate the characteristics carbapenem-resistant Klebsiella pneumoniae (CRKP) ST76 isolates collected during an outbreak in a hospital's intensive care unit and neurosurgery unit. Methods: Seventeen separate clinical CRKP were from patients March 2016 February 2017. Bacterial identified, antimicrobial susceptibility testing conducted using VITEK-2 compact system. Isolates containing antibiotic resistance genes characterized by polymerase chain...
Abstract Pyroptosis provides a novel perspective for the design of anti‐tumor strategies. However, when pyroptosis reaches plateau, its negative role becomes “defense” signaling to evade immune surveillance. Herein, triblock polymeric micelles TPT@PIO NPs are reported, including hydrophobic block backbone poly (propylene sulfide) (PPS), side chain disulfide bond‐bearing indomethacin (MABHD‐IND), hydrophilic poly(ethylene glycol) methyl ether methacrylate (OEGMA), and an encapsulated drug...
Selecting alternative antibiotic combinations as treatment options may help successfully manage carbapenem-resistant Acinetobacter baumannii (CRAB). This study aimed to determine the synergistic effects of tigecycline (TIG) monotherapy versus combination therapy with other antimicrobials against CRAB.After performing biochemical identification assays, we detected oxacillin-hydrolyzing (OXA)-type carbapenemase genes in 35 CRAB isolates. The minimum inhibitory concentrations (MICs) and...
The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has become a significant problem for global public health. Currently, treatments program is minimal. This study aimed to evaluate the molecular mechanisms Enterobacter cloacae complex isolates (CREC) infections. Methods: Resistance genes were detected using PCR with specific primers. Multilocus sequence typing (MLST) was also performed. Furthermore, we evaluated effects polymyxin B (PMB) and tigecycline (TGC) antibiotics (Abs)...
Background: Enterobacter cloacae is an emerging opportunistic pathogen. We retrospectively conducted a study to assess antimicrobial susceptibility and investigated the Molecular characteristics of carbapenem-resistant (CREL) isolates. Method: Three hundred forty-two isolates were collected from January 2014 December 2018. Ten strains CREL for further research. The species identifications minimum inhibitory concentrations (MICs) all antibiotics tested analyzed using Vitek 2 Compact system...
The purpose of this study was to describe the patterns out-field regional recurrence after involved-field irradiation (IFI) in definitive concurrent chemoradiotherapy (CCRT) for locally advanced esophageal squamous cell carcinoma (LA-ESCC) and identify possible risk factors.Eighty patients with LA-ESCC who received CCRT IFI between January 2003 2009 at Shandong Cancer Hospital were recruited analyzed. Imaging scans demonstrating first sites failure compared original computed tomography-based...