A5102816995- Ferroptosis and cancer prognosis
- Organ Transplantation Techniques and Outcomes
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Circular RNAs in diseases
- Abdominal Surgery and Complications
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Advanced Glycation End Products research
- Renal Transplantation Outcomes and Treatments
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Immune Response and Inflammation
- Extracellular vesicles in disease
- Pancreatitis Pathology and Treatment
- Organ Donation and Transplantation
- Appendicitis Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- T-cell and B-cell Immunology
First Affiliated Hospital of Kunming Medical University
2013-2025
Kunming Medical University
2009-2025
Ningxia Medical University General Hospital
2024
Ningxia Medical University
2024
National Clinical Research Center for Digestive Diseases
2024
Second Affiliated Hospital of Kunming Medical College
2009
BACKGROUND CD8+ cytotoxic T lymphocytes (CTLs) have been proved to exert crucial roles in immunological rejection. Exosomes (EXOs) secreted by CD4+CD25+ regulatory (Treg) cells is believed be deeply involved immune regulation. Nevertheless, whether immunomodulatory effect of Treg on CTL depends EXOs remains unknown and needs explored. MATERIAL AND METHODS We purified followed vitro amplification. culture supernatants was separated identified. The cells-derived viability, proliferation, cell...
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<title>Abstract</title> Background Heme oxygenase 1 (HMOX1), known for its anti-inflammatory properties, is crucial iron homeostasis, antioxidation, and apoptosis prevention. However, role in various malignancies not well understood. This research aimed to analyze immunocorrelation study HMOX1's prognostic significance pan-cancer. Methods The RNA-seq data expression of HMOX1 were mined from Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases. Limma package was utilized...
ABSTRACT Gene‐edited (GE) pig‐to‐human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ‐specific transplantation remains unclear. In this study, we utilised CRISPR/Cas9 editing technology, PiggyBac transposon system, and serial somatic cell cloning technology develop GTKO/CMAHKO/β4GalNT2KO/hCD46/hCD55/hCD59/hCD39/hTBM 8 gene‐edited cloned (GEC) donor pigs performed pig‐to‐non‐human primate (NHP) evaluate the effectiveness these GEC...
Hepatic ischemia reperfusion (I/R) injury (HIRI) HIRI is a complex, multifactorial pathophysiological process and in liver surgery has been known to significantly affect disease prognosis, surgical success rates, patient survival. Ginsenoside Rgl (Rgl) monomer one of the main active ingredients ginseng. Previous studies have demonstrated that exerts various pharmacological effects through several mechanisms including suppression apoptosis-related proteins levels, downregulation inflammatory...
Abstract Background Upregulation of Stathmin 1 (STMN1), a cytoplasmic phosphoprotein that controls the dynamics cellular microtubules, is linked to malignant behavior and poor prognosis in range malignancies. However, little research has been done on STMN1’s potential role HCC as single factor DNA methylation, m 6 A, or immunological modulation. Results STMN1 overexpressed hepatocellular carcinoma, where it related clinicopathological parameters affects patients. overexpression plays an...
Excessive proinflammatory cytokine release induced by pyroptosis plays a vital role in intestinal mucosal inflammation ulcerative colitis (UC). Several pyroptosis-related factors are regulated the centrosome. Pericentriolar material 1 (PCM1) is primary component of centriolar satellites that present as cytoplasmic granules around Our previous study revealed PCM1 was highly expressed UC patients, but remains unknown. This aimed to elucidate development UC, especially mechanism process UC....
Hepatic ischemia-reperfusion (IR) injury remains the major cause of liver damage post-liver surgery or transplantation. Diminishing oxidative stress and inflammatory responses is a powerful channel to reduce rate morbidity mortality. Gastrodin (GSTD), bioactive compound extracted from traditional Chinese herbal agent with long history clinical application in nervous system diseases, suggested possess anti-oxidative effects on such as nonalcoholic fatty disease. However, therapeutic potential...
Objective: Heme oxygenase-1 (HO-1) is a protein involved in the inflammatory response following ischemia-reperfusion injury (IRI). Evidence suggests that pyroptosis plays an important role IRI. However, underlying mechanism between HO-1 and IRI requires further investigation. Methods: Using “two-cuff” method, Sprague Dawley rat model of liver transplantation (LT) was established using livers from donors after circulatory death. An automatic biochemical analyzer used to detect serum alanine...
Allogeneic kidney transplantation (renal allograft) is the most effective treatment for advanced disease. Previous studies have indicated that ferroptosis participates in progression of acute injury and renal transplant failure. However, few evaluated prognostic value on outcomes. In this study, a total 22 differentially expressed ferroptosis-related genes (DFGs) were identified, which mainly enriched infection-related pathways. Next, gene signature, including GA-binding protein...
In liver transplant cases, severe hepatic ischemia/reperfusion injury (HIRI) is a strong predictor of adverse graft and overall outcomes. During HIRI, high‐mobility group box 1 (HMGB1) promotes hepatocellular death proinflammatory cytokine secretion by toll‐like receptor 4 (TLR4). Because salicylates inhibit HMGB1/TLR4 interaction, we hypothesized that may ameliorate HIRI‐induced damage inhibiting axis activation. Using murine model found the salicylate acetyl‐3‐aminoethyl salicylic acid...
The mechanistic basis for relapsed hepatocellular carcinoma (HCC) remains poorly understood. Recent research has highlighted the important roles of long non-coding RNAs (lncRNAs) in HCC. However, there are only a few studies on association between lncRNAs and HCC relapse. Differentially expressed mRNAs primary group were identified using edge R package to analyze GSE101432 dataset. differentially used construct lncRNA-mRNA co-expression network. Weighted gene network analysis followed by...
High-grade glioma (HGG) patients frequently encounter treatment resistance and relapse, despite numerous interventions seeking enhanced survival outcomes yielding limited success. Consequently, this study, rooted in our prior research, aimed to ascertain whether leveraging circadian rhythm phase attributes could optimize radiotherapy results. In retrospective analysis, we meticulously selected 121 HGG cases with synchronized rhythms through Cosinor analysis. Post-surgery, all subjects...
Background: Hepatic ischemia reperfusion injury often leads to increased complications and mortality after surgery. Although ischemic preconditioning is used as a convenient effective method protect the liver from warm injury, optimal protocol currently unclear. Therefore, in this study, we sought identify ideal conditions methods for preconditioning. Materials methods: We compared several protocols of ischemia/reperfusion (I/R) cycle 30 male Sprague-Dawley rats (5 groups, n = 6), including...
Mitochondrial phosphoenolpyruvate carboxykinase (PCK2), a mitochondrial isoenzyme, supports the growth of cancer cells under glucose deficiency conditions in vitro. This study investigated role and potential mechanism PCK2 occurrence development Hepatocellular carcinoma (HCC). The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), other databases distinguish expression verified by qRT-PCR Western blotting. Kaplan-Meier was conducted to assess survival HCC. biological function...
Liver transplantation (LT) offers a good survival chance for both the patient in short or long term, but still faces many challenges treatment of LT, such as side effects associated with long-term immunosuppression, which is one that occurs most patients. However, dynamics cellular immune system composition over time during tolerance to LT after immunosuppressive therapy are not known.Using single-cell transcriptome sequencing, we analyzed five peripheral blood samples (one normal individual...
Abstract Background. Cirrhosis is defined as diffuse liver fibrosis (LF) caused by various chronic diseases and characterized excessive deposition of extracellular matrix in tissue. However, the molecular mechanism cirrhosis has not been well understood. This study aimed to identify significant gene expression profiles that participate pathogenesis using bioinformatics discover novel biomarkers. Methods. Two LF datasets (GSE14323 GSE139602), both consisted patients healthy individuals, were...
Cirrhosis is defined as diffuse liver fibrosis (LF) caused by various chronic diseases and characterized excessive deposition of extracellular matrix in tissue. However, the molecular mechanism cirrhosis has not been well understood. This study aimed to identify significant gene expression profiles that participate pathogenesis using bioinformatics discover novel biomarkers. Two LF datasets (GSE14323 GSE139602), both consisted patients healthy individuals, were obtained from Gene Expression...
Background: While the prevalence of obesity and its negative effects on graft steatosis in liver transplantation are well recognized, impact absence hepatic steatosis, fibrosis, inflammation deceased donor livers remains unclear. This knowledge gap may affect decision to adopt a transplant strategy influence following outcomes. Methods: A population-based cohort study was performed 35,529 donors who received biopsy from 1987 2024. Donor BMI categorized assessed for association with...
AbstractBackground: The increasing prevalence of fibrosis in donor livers raises concerns about its impact on post-transplantation outcomes, though this relationship remains unclear. This study aims to assess the effect liver patient and graft survival following transplantation.Methods: Data from UNOS-STAR registry (1987–2024) were analyzed, focusing patients who received transplants with biopsy-proven fibrosis. cohort was stratified based grade, outcomes compared using Cox regression...