A5101367257- Metal-Organic Frameworks: Synthesis and Applications
- Xenotransplantation and immune response
- Molecular Sensors and Ion Detection
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Building Energy and Comfort Optimization
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Ubiquitin and proteasome pathways
- Crystallography and molecular interactions
- Advanced Nanomaterials in Catalysis
- Advanced Photocatalysis Techniques
- Cancer Cells and Metastasis
- Advanced Memory and Neural Computing
- Wind and Air Flow Studies
- Natural Compounds in Disease Treatment
- Analytical Chemistry and Chromatography
- Probabilistic and Robust Engineering Design
- Supramolecular Self-Assembly in Materials
- Natural product bioactivities and synthesis
- Ferroptosis and cancer prognosis
- Brain Metastases and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- HVDC Systems and Fault Protection
Lanzhou University of Technology
2023-2025
Yunnan Agricultural University
2024-2025
Gansu Provincial Maternal and Child Health Hospital
2024-2025
Gansu Provincial Hospital
2025
Anhui University
2024
Affiliated Hospital of Hebei University
2022-2024
Anhui University of Traditional Chinese Medicine
2023
Renji Hospital
2023
Shanghai Jiao Tong University
2023
Hebei University
2022-2023
Abstract As a terpenoids natural product isolated from the plant Thunder God Vine , Celastrol is widely studied for its pharmacological activities, including anti-tumor activities. The clinical application of strictly limited due to severe side effects, whereas previously revealed targets and mechanism seldom reduce in vivo toxicity via structural optimization. Target identification has far-reaching influence on development innovative drugs, omics data been used unbiased target prediction....
Chiral metal-organic frameworks (MOFs) have attracted much attention due to their highly tunable regular microporous structures. However, chiral electrochemical recognition based on MOFs is often limited by poor charge separation and slow transfer kinetics. In this case, C
The introduction of chirality into easy-scalable metal–organic frameworks (MOFs) gives rise to the development advanced electrochemical sensors. However, integrating by directly connecting metal ions and chiral ligands is unpredictable. Postmodification synthesis a common method for synthesizing MOFs, but it reduces size channels poses obstacles approach guest molecules. In this work, missing connection defects were introduced MOFs through defect engineering strategies, which enhance...
A summary and discussion on the recent research advances in chiral carbon materials based various nanomaterials.
The enantioselective recognition and separation of racemic tryptophan are significant importance in the fields medicine, pharmaceutics, biochemistry. However, conventional methods costly, energy intensive, environmentally unfriendly. In this case, l-Cys with amino (-NH2) sulfhydryl (-SH) groups was chosen to modify β-CD a chiral cavity achieve self-assembly via hydrogen bonding, which not only serves as an electrochemical sensor enhanced sites at sensing interface but also achieves higher...
ABSTRACT Gene‐edited (GE) pig‐to‐human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ‐specific transplantation remains unclear. In this study, we utilised CRISPR/Cas9 editing technology, PiggyBac transposon system, and serial somatic cell cloning technology develop GTKO/CMAHKO/β4GalNT2KO/hCD46/hCD55/hCD59/hCD39/hTBM 8 gene‐edited cloned (GEC) donor pigs performed pig‐to‐non‐human primate (NHP) evaluate the effectiveness these GEC...
Chiral channels or pores are a fundamental feature of chiral metal–organic frameworks (CMOFs). However, the roles and have always been overlooked in enantioselective sensing based on CMOFs. Aiming at platforms enantioselectivity with efficient electrochemical recognition, L-His, L-Glu, L-Lys introduced into framework (MOF) as Taking advantage postsynthetic modifications (PSM), resulting CMOFs (MOF-His/MOF-Glu/MOF-Lys) exhibit channel dependence for different amino acid enantiomers. Ascribed...
A biomimetic chiral MOF, ZnBTCHx, was synthesized by mimicking a DNA groove. The adaptability of the local shape ZnBTCHx can facilitate specific recognition guest.
Abstract Chirality exists everywhere in nature, so chiral recognition is also an extremely important field. This paper explores the of amino acid configuration by electrochemical sensing platform constructed with carbon nanomaterials (carbon quantum dots (CQDs) as substrate material) combined selectors (chitosan (CS)). CQDs/CS, which bonded intermolecular force, and CQDs‐CS, formed covalent grafting through amidation, are selected materials, a series characterization methods carried out to...
A defective CuS/Cv-CNNs heterojunction is proposed, which promotes its adsorption and photodegradation of Cr( vi ) through the synergistic effect multiple defects, thus accelerating removal high concentrations ).
ABSTRACT Background The number of multigene‐modified donor pigs for xenotransplantation is increasing with the advent gene‐editing technologies. However, it remains unclear which gene combination suitable specific organ transplantation. Methods In this study, we utilized CRISPR/Cas9 editing technology, piggyBac transposon system, and somatic cell cloning to construct GTKO/hCD55/hTBM/hCD39 four‐gene‐edited cloned (GEC) performed kidney transplantation from pig rhesus monkey evaluate...
Hypoxia inducible factor-1α (HIF-1α) plays a critical role in cellular adaptation to hypoxia and it is potential therapeutic target for anti-cancer drugs. Applying high-throughput screening, here found that HI-101, small molecule containing an adamantaniline moiety, effectively reduces HIF-1α protein expression. With the compound as hit, probe (HI-102) developed identification by affinity-based profiling. The catalytic β subunit of mitochondrial FO F1 -ATP synthase, ATP5B, identified binding...
The different types of point defects effectively enhance the adsorption and photocatalytic capacity N-GCC hydrogel, hydrogel structure has ability to mitigate risk material causing cuproptosis life forms in nature.
To observe the effects of moxibustion with different frequency on disease activity and fatigue rheumatoid arthritis (RA) liver kidney deficiency basis western medication treatment.
This study investigates the potential mechanism of moxibustion in treatment rheumatoid arthritis (RA) by regulating neutrophil extracellular trap (NET)/NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome axis with use a rat model adjuvant (AA).
The fruit of Broussonetia papyrifera (L.) L’Herit. ex Vent. is a traditional Chinese medicine with name Chushizi. It has been commonly used as an important tonic for the treatment of age-related disorders. In this work, antioxidant properties oil were investigated on nitric oxide production in lipopolysaccharide (LPS), activated RAW264.7 cells along 1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide anion hydroxyl radical scavenging assays. chemical composition was analyzed by Gas...