A5108800793- Nanoplatforms for cancer theranostics
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Cellular Mechanics and Interactions
- Metal-Organic Frameworks: Synthesis and Applications
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Nonlocal and gradient elasticity in micro/nano structures
- Advanced Sensor and Energy Harvesting Materials
- Aerogels and thermal insulation
- Biological and pharmacological studies of plants
- Gold and Silver Nanoparticles Synthesis and Applications
- Carbon Nanotubes in Composites
- Nanopore and Nanochannel Transport Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanofabrication and Lithography Techniques
- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Luminescence and Fluorescent Materials
- Neurological Disease Mechanisms and Treatments
- 2D Materials and Applications
- Layered Double Hydroxides Synthesis and Applications
Ningbo Institute of Industrial Technology
2019-2025
Chinese Academy of Sciences
2009-2025
Dalian Medical University
2024
Second Affiliated Hospital of Dalian Medical University
2024
Ji Hua Laboratory
2022-2024
University of Illinois Urbana-Champaign
2024
Josai University
2022-2023
Sichuan Fire Research Institute
2023
Tianjin University
2018-2022
Guangdong Polytechnic of Industry and Commerce
2017-2022
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), one of the first found cancer-associated long noncoding RNAs (lncRNAs), involves in development and progression many types tumors. An aberrant expression MALAT1 was observed hepatocellular carcinoma, cervical cancer, breast ovarian colorectal cancer. However, exact effects molecular mechanisms osteosarcoma are still unknown up to now. Here, we investigated role human cell lines clinical tumor samples order determine function...
The fabrication of tubular structures, with multiple cell types forming different layers the tube walls, is described using a stress-induced rolling membrane (SIRM). Cell orientation inside tubes can also be controlled by topographical contact guidance. These layered precisely mimic blood vessels and many other suggesting that they may great use in tissue engineering. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but...
The unique properties of two-dimensional (2D) materials make them promising candidates for chemical and biological sensing applications. However, most 2D material sensors suffer from extremely long recovery time due to the slow molecular desorption at room temperature. Here, we report an ultrasensitive p-type molybdenum ditelluride (MoTe2) gas sensor NO2 detection with greatly enhanced sensitivity rate under ultraviolet (UV) illumination. Specifically, is dramatically by 1 order magnitude...
Injectable HA/PEG hydrogel was crosslinked by integrating the enzymatic crosslinking and Diels–Alder click chemistry showed excellent shape recovery anti-fatigue properties at a high compressive stress.
The boosted SERS activity is attributed to a high-efficiency PICT process due the significant reduction of non-radiative recombination at low temperature.
Given that apoptosis increases the risk of plaque rupture, strategies reduce intracellular lipid levels without killing foam cells are warranted for safe and effective treatment atherosclerosis. In this study, a mild phototherapy strategy is carried out to achieve hypothesis. Foam cell-targeted nanoprobes allow photothermal therapy (PTT) and/or photodynamic (PDT) were prepared by loading hyaluronan porphine onto black TiO2 nanoparticles. The results showed when temperatures below 45 °C, PTT...
Abstract Personalized radiotherapy strategies enabled by the construction of hypoxia‐guided biological target volumes (BTVs) can overcome hypoxia‐induced radioresistance delivering high‐dose to targeted hypoxic areas tumor. However, BTVs is difficult owing lack precise visualization areas. This study synthesizes a hypoxia‐responsive T 1 , 2 mapping tri‐modal MRI molecular nanoprobe (SPION@ND) and provides imaging tumor utilizing advantageous features magnetic resonance (MRI). SPION@ND...
Fenced in: Selective electrochemical desorption of self-assembled monolayers HS(CH2)11(OCH2CH2)6OH was carried out on parts a gold substrate restricted to microfluidic channels. This chemical transformation activates the surface for adhesion multiple types cells with well-controlled geometry.
Nuclear factor erythroid-related 2 (Nrf2) has been implicated in several detoxifying and antioxidant defense processes. Nrf2-mediated heme oxygenase-1 (HO-1) expression was demonstrated to play a key role against oxidative stress. Gastrodin (GSTD) is well-known active compound isolated from the roots of Rhizoma gastrodiae, plant used ancient Chinese traditional medicine. The aim this work investigate whether GSTD could alleviate H2O2-induced stress mouse liver sinusoidal endothelial cells...
Surface topography can affect cell adhesion, morphology, polarity, cytoskeleton organization, and osteogenesis. However, little is known about the effect of on fracture healing in repairing nonunion large bone defects. Microgrooved surface implants may promote migration into gap to accelerate healing. To prove this hypothesis, we used an vitro (wound) assay microgrooved polycaprolactone substrates study microgroove widths depths osteoblast-like (MG-63) subsequent We found that promoted MG-63...
Abstract Zeolitic imidazolate frameworks (ZIFs) as smart drug delivery systems with microenvironment-triggered release have attracted much attention for tumor therapy. However, the exploration of ZIFs in biomedicine still encounters many issues, such inconvenient surface modification, fast during blood circulation, undesired damage to major organs, and severe vivo toxicity. To address above we developed an Mn-ZIF-90 nanosystem functionalized originally designed active-targeting pH-responsive...
Zeolitic Imidazole Frameworks (ZIFs) are widely applied in nanomedicine for their high drug loading, suitable pore size, pH-responsive release, and so on. However, fast release during circulation, unexpected toxicity to mice major organs, undesirable long-term accumulation the lung even death currently hinder vivo biomedical applications. Herein, we report an amorphous ZIF-8 (aZIF-8) with loading of 5-Fu through pressure-induced amorphization. This nano-system avoids early circulation...
A <italic>T</italic><sub>1</sub>–<italic>T</italic><sub>2</sub> switchable MRI contrast agent, hyaluronic acid-modified iron oxide nanoparticle–polyacrylic acid, is used for the identification of vulnerable atherosclerotic plaques by macrophage phagocytosis. It could reveal promising enhancement in MRI.
Abstract A novel method combining microfluidic channels and holey poly(dimethylsiloxane) PDMS membranes is presented for patterning multiple types of cells on a large variety substrate, including substrate bearing micro‐ nanometer‐scale structures. Different kinds cell are patterned diverse flat substrates composed various materials. Further, different with microgrooved the influence cell–cell cell–substrate interactions about group behaviors shown. This provides new approach studying many...
The selective and sensitive detection of chemical agents is demanded by a wide range practical applications. In particular, sensing volatile organic compounds (VOCs) at parts-per-billion level critical for environmental monitoring, process control, early diagnosis human diseases. this report, we demonstrate specific highly ketone using two-dimensional (2D) molybdenum ditelluride (MoTe2). We investigated the effects UV activation on performance to variety VOCs. It found that MoTe2...