A5109285281- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Cell Adhesion Molecules Research
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Microfluidic and Bio-sensing Technologies
- RNA Research and Splicing
- Erythrocyte Function and Pathophysiology
- Cancer-related molecular mechanisms research
- Nanofabrication and Lithography Techniques
- Force Microscopy Techniques and Applications
- Nanoplatforms for cancer theranostics
- Adipose Tissue and Metabolism
- Heat shock proteins research
- Bone Tissue Engineering Materials
- Thermoregulation and physiological responses
- Polymer Surface Interaction Studies
- MRI in cancer diagnosis
- RNA modifications and cancer
- Marine Bivalve and Aquaculture Studies
- Cardiac Valve Diseases and Treatments
- Lipid Membrane Structure and Behavior
- Cardiac Structural Anomalies and Repair
- Physiological and biochemical adaptations
- Molecular Biology Techniques and Applications
Institute of Hydrobiology
2016-2024
Chinese Academy of Sciences
2009-2024
University of Chinese Academy of Sciences
2016-2024
General Hospital of Shenyang Military Region
2024
National Center for Nanoscience and Technology
2015-2024
Beijing University of Chinese Medicine
2022-2024
Second Military Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
National University of Singapore
2024
Suzhou Research Institute
2024
A nanostructured platform that combines silicon nanowire arrays and DNA aptamers realizes significant capture efficient release of T lymphocytes. An approximately two orders magnitude enhancement in efficiency compared to planar surfaces is observed with good performance. This method provides an artful strategy fulfill the demands cell isolation diagnosis. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited...
Intercellular interactions between cardiomyocytes (CMs) and cardiofibroblasts (FBs) are important in the physiological pathophysiological heart. Understanding such is for developing effective heart disease therapies. However, until recently, little has been known about these interactions. We aimed to investigate structural functional connections CMs FBs that distinct from gap junctions. By membrane dye staining, we observed long, thin nanotubular structures containing actin microtubules...
The softness of materials is very important in cellular processes, such as cell adhesion, spread, proliferation and differentiation. Using soft benefits many biological studies applications, wound healing, tissue engineering clinical surgery. However, other areas, rare cancer-cell capture isolation, the importance has not yet been studied. Extracellular matrix suitable for contact survival formed from with specific molecules nanostructures. Herein, we report a polystyrene nanotube substrate...
Abstract China has dominated global aquaculture production for more than two decades. Aquaculture in increased from 24.6 million metric tons (mmt) 2000 to 47.5 mmt 2014, an increment of 93.1%. Along with the fast‐growing industry, aquafeed 5.1 19.0 272.5%. However, despite rapid increase production, fishmeal usage aquafeeds remained stable over years. Fishmeal imports into relatively steady at 1.0–1.5 per annum 2014. An often unacknowledged fact is that contributes 60% world a cost only...
Triptolide exhibits promising efficacy in various cancers and immune diseases while its clinical application has been strongly restricted by severe side effects, especially cardiotoxicity. However, the underlying mechanism of triptolide-induced cardiotoxicity (TIC) remains unclear. The RNA-seq analysis triptolide-injured AC16 human cardiomyocyte cell line hinted that ferroptosis is involved TIC. Further experimental validations proved triptolide triggered ferroptosis, as evidenced...
This study investigated the potential role of curcumin (CUR) in preventing oxidative stress and ferroptosis induced by ammonia exposure gibel carp. Experimental fish (initial weight: 11.22 ± 0.10 g, n = 150) were fed diets supplemented with or without 0.5% CUR for 56 days, followed a 24 h (32.5 mg/L) exposure. Liver damages (aspartate aminotransferase (AST), alanine (ALT), adenosine deaminase (ADA), alkaline phosphatase (ALP)) enzyme activities (reactive oxygen species (ROS), malondialdehyde...
Fenced in: Selective electrochemical desorption of self-assembled monolayers HS(CH2)11(OCH2CH2)6OH was carried out on parts a gold substrate restricted to microfluidic channels. This chemical transformation activates the surface for adhesion multiple types cells with well-controlled geometry.
Immune cells exhibit distinct stereospecific behaviors on enantiomorphous surfaces with different chiralities. It may not only bring interesting insight to the design of novel high-performance biocompatible materials but also help better understand high selectivity chirality in biosystems.
To describe detailed behaviour of cell spreading under the influence substrate stiffness, A549 cells cultured on surfaces polydimethylsiloxane (PDMS) and polyacrylamide (PAAm) with bulk rigidities ranging from 0.1 kPa to 40 were in situ observed. The PAAm presented a positive correlation between speed stiffness. After computing deformations gels collagen, stiffness PAAm, rather than matrix tethering, determined behaviour. On other hand, was unaffected by varying PDMS. Based simulation...
A schematic for the mechanism of accelerating assembly intercalated discs (IDs) in cardiac myocytes regulated by gold nanoparticles (AuNPs) is presented. AuNPs with local nanoscale stiffness substrate activate β1-integrin signaling, which mediates activation integrin-linked kinase (ILK) and its downstream signal stimulating expression transcription factors GATA4 MEF-2c.
Abstract Bacterial infectious diseases, such as sepsis, can lead to impaired function in the lungs, kidneys, and other vital organs. Although established technologies have been designed for extracorporeal removal of bacteria, a high flow velocity true bloodstream might result low capture efficiency prevent realization their full clinical potential. Here, we develop dialyzer made by three-dimensional carbon foam pre-grafted with nanowires isolate bacteria from unprocessed blood. The tip...
Ammonia is recognized as an environmental stressor for fish. As resveratrol (RES) has anti-inflammatory and antioxidant properties, we hypothesized that RES could attenuate the response to ammonia exposure in gibel carp. Therefore, carp were fed a diet containing eight weeks, followed by acute stimulation. Stress induced be ameliorated RES, manifested down-regulated plasma glucose, up-regulated C3 IgM levels. Furthermore, decreased AST LDH; enhanced T-AOC, SOD, GPx liver; reduced damage gill...
The question of how cells sense substrate mechanical cues has gained increasing attention among biologists. By introducing contour-based data analysis to single-cell force spectroscopy, we identified a loading-rate threshold for the integrin α2β1–DGEA bond beyond which dramatic increase in lifetime was observed. On basis (elasticity or topography), effective spring constant substrates k is mapped loading rate r under actomyosin pulling speed v, which, turn, affects integrin–ligand bond....
A growth trial was conducted to evaluate the effects and safety of nucleotides in low fish meal diets on performance, antioxidative capacity intestinal morphology turbot (Scophthalmus maximus). High control diet formulated with 500 g kg−1 meal. Seven levels (0.075, 0.15, 0.225, 0.300, 1.5 3.0 kg−1, respectively) were added a basal diet, which 400 The eight experimental fed groups juvenile (initial weight: 6.0 ± 0.03 g) for 60 days. Results showed that compared high treatment had lower total...
Gold nanoparticles and carbon nanotubes have attracted substantial attention in recent years for their potential applications photothermal therapy (PTT) as an emerging breakthrough cancer treatment. Herein, a hybrid nanomaterial of gold nanostars/multiwalled (MWCNTs) was synthesized by two-step reduction via the control several synthetic conditions such reducing agent, pH value, concentration ratio reagents. The material shows good biocompatibility high conversion efficiency, demonstrating...
Introduction Resveratrol (RES) is a polyphenol organic compound with antioxidant and anti-inflammatory properties. This study aimed to determine whether how RES can alleviate liver injury in lipopolysaccharide (LPS)-induced gibel carp. Methods Gibel carp were fed diet or without cultured for 8 weeks, followed by LPS injection. Results discussion The results suggested that attenuated the resulting oxidative stress inflammation activating Nrf2/Keap1 pathway inhibiting NF-κB pathway, as...