A5100364001- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Structural Load-Bearing Analysis
- Structural Engineering and Vibration Analysis
- Structural Health Monitoring Techniques
- Smart Grid and Power Systems
- Geochemistry and Geochronology of Asian Mineral Deposits
- Hydrocarbon exploration and reservoir analysis
- Advanced Measurement and Detection Methods
- Force Microscopy Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Spaceflight effects on biology
- Silk-based biomaterials and applications
- Power Systems Fault Detection
- Radioactive element chemistry and processing
- Soil, Finite Element Methods
- Electromagnetic Launch and Propulsion Technology
- Bone health and osteoporosis research
- Innovative Educational Techniques
- Neonatal and Maternal Infections
- Advanced Thermodynamics and Statistical Mechanics
- Magneto-Optical Properties and Applications
- Advanced Combustion Engine Technologies
- Advanced Optical Sensing Technologies
- Signaling Pathways in Disease
University of Chinese Academy of Sciences
2021-2024
Tsinghua University
2013-2024
Zhejiang Lab
2024
Nanchang Hangkong University
2012-2023
Nanjing University of Science and Technology
2013
China Pharmaceutical University
2000
Kangmei Pharmaceutical (China)
1996
Xiaomi (China)
1995
Heritage Christian University
1993
Abstract It is well established that extracellular matrix (ECM) stiffness plays a significant role in regulating the phenotypes and behaviors of many cell types. However, mechanism underlying sensing mechanical cues subsequent elasticity-triggered pathways remains largely unknown. We observed stiff ECM significantly enhanced expression level several members Wnt/β-catenin pathway both bone marrow mesenchymal stem cells primary chondrocytes. The activation β-catenin by not dependent on Wnt...
The question of how cells sense substrate mechanical cues has gained increasing attention among biologists. By introducing contour-based data analysis to single-cell force spectroscopy, we identified a loading-rate threshold for the integrin α2β1–DGEA bond beyond which dramatic increase in lifetime was observed. On basis (elasticity or topography), effective spring constant substrates k is mapped loading rate r under actomyosin pulling speed v, which, turn, affects integrin–ligand bond....
Textile triboelectric nanogenerators (TENGs) that integrate the newly developed TENG science and traditional textile technology have attracted intense attentions, due to their broad potential applications in wearable power supply self-powered sensors. However, limited electrical output ability has greatly hindered development of TENGs. Here, with help advanced three-dimensional (3D) warp-knitted structure, a scalable washable 3D spacer fabric (3D-WSF) high compression elasticity enhanced is...
Change in p53 Nuclear Localization Response to Extracellular Matrix Stiffness Description: The cover image uses a blue sphere represent the nucleus and black area cytoplasm. We use orange green subcellular localisation of cells after soft rigid substrate treatment, respectively. It can be seen that softer significantly increased nuclear chondrocytes.
Mechanical stimuli play crucial roles in bone remodeling and resorption. Osteopontin (OPN), a marker for osteoblasts, is important cell communication matrix mineralization, known to function during mechanotransduction. Hypergravity convenient approach forge mechanical on cells. It has positive effects certain markers of osteoblast maturation, making it possible strategy tissue engineering. We investigated the hypergravity OPN expression signaling osteoblasts. treatment at 20 g 24 hours...
Caveolae-mediated vesiculation refers to the ∼100 nm cave-like plasma membrane invaginations, which function as macromolecular transport vesicles that regulate cellular function. The initiation of is closely associated with protein–protein and protein–membrane interactions, yet their roles in caveolae budding process are not well-understood. We here propose a dual-scale model, allows us identify unique role for caveolin–dioleoylphosphatidylserine (DOPS) interaction high-order oligomer...
Abstract Chondrocytes are commonly applied in regenerative medicine and tissue engineering. Thus, the discovery of optimal culture conditions to obtain cells with good properties behavior for transplantation is important. In addition biochemical cues, physical biomechanical changes can affect proliferation protein expression chondrocytes. Here we investigated effect extracellular matrix stiffness on mouse articular chondrocyte phenotype, growth, subcellular p53 localization. were seeded...
A mapping * : × → is a (binary) operation, and the pair (, ) named as Magma [1 ].Magma with property: = for all , in L-cyclic magma or property Rcyclic magma.In this paper, every result show only identical gaol, that to prove when becomes R-cyclic vice versa .
Due to the change in bank's attitudes towards mortgage prepayment risk, as well increasing valuation needs for mortgage-backed securities, prediction on individual behavior is becoming more and indispensable. This paper analyzes main factors influencing Chinese mortgage-loan from a modeling perspective. Based unexpected events, sale, inheritance other investment income, model was established assist commercial banks managing effectively, hasten development of securities.
The historical and cultural resources of Jiangxi aviation are profound have a very important value the times. Standing on new journey building an power in era, this paper deeply explores studies Jiangxi's heavy history culture, puts forward development strategy utilization path according to requirements It is expected provide useful experience spiritual encouragement for carrying spirit serving country, realizing dream, era.
Chinese-style education modernization is an important part of modernization, and promoting inevitable requirement for building a strong socialist modern country in all aspects. Therefore, the promotion modernisation has become strategic initiative direction national development. Taking this opportunity to explore value implications, practical issues ways promote great significance enabling high-quality development Chinese realising style modernization. In face new pattern, it necessary...
Objective: To investigate the effect of polydimethylsiloxane (PDMS) matrix elasticity on osteogenic differentiation rat marrow stromal cells (rBMSC). Methods: A series PDMS composite substrates with different elastic modulus were constructed by adjusting relative concentrations cross-linking agent. The Young's was used to describe after measurement atomic force microscope (AFM). After surface modification, rBMSC seeded matrix, and 7 days cultured five moduli differences observed method...
Extracellular matrix (ECM) elasticity affects the function of a variety cells. Integrins are transmembrane receptors that considered to be sensor cellular mechanical stimulation. The activity integrins is strongly ... | Find, read and cite all research you need on Tech Science Press