A5011288700- Ferroptosis and cancer prognosis
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Folate and B Vitamins Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Ultrasound and Hyperthermia Applications
- Liver Disease and Transplantation
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Inflammation biomarkers and pathways
- Cancer, Hypoxia, and Metabolism
- Remote Sensing and Land Use
- Pancreatitis Pathology and Treatment
- RNA modifications and cancer
- Animal Nutrition and Physiology
- Apelin-related biomedical research
- Histone Deacetylase Inhibitors Research
- Polyomavirus and related diseases
- Metal and Thin Film Mechanics
- Cancer Mechanisms and Therapy
- Microbial Fuel Cells and Bioremediation
- Bone and Dental Protein Studies
Shanghai East Hospital
2025
First People's Hospital of Chongqing
2024-2025
Guangzhou University
2025
People's Hospital of Kaizhou District
2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Zhujiang Hospital
2022
Chongqing Medical University
2011-2020
Dalian Medical University
2011-2020
Second Affiliated Hospital of Chongqing Medical University
2011-2020
HA-TPP NHs constructed by chemical crosslinking fixing photosensitizers for reducing the aggregation of produce more singlet oxygen and have a better killing effect on tumor cells, compared to assembling NPs.
Managing nitrogen and phosphorus pollution in high-salinity wastewater is a critical challenge for sustainable aquaculture environmental protection. In this study, novel salt-tolerant strain, Pseudomonas sediminis D4, was isolated from brackish water environment. This strain exhibited simultaneous heterotrophic nitrification–aerobic denitrification removal capabilities. Biosafety assays demonstrated that the antibiotic-sensitive safe aquatic environments. The optimal conditions phosphate of...
Long-term survivals of patients with hepatocellular carcinoma (HCC) remain unfavorable, which is largely attributed to active carcinogenesis. Growing studies have suggested that the reliable gene signature could act as an independent prognosis factor for HCC patients. We tried screen survival-related genes and develop a prognostic prediction model based on expression profiles critical genes. In this study, we analyzed TCGA datasets identified 280 differential expressions (125 increased 155...
In liver transplant cases, severe hepatic ischemia/reperfusion injury (HIRI) is a strong predictor of adverse graft and overall outcomes. During HIRI, high‐mobility group box 1 (HMGB1) promotes hepatocellular death proinflammatory cytokine secretion by toll‐like receptor 4 (TLR4). Because salicylates inhibit HMGB1/TLR4 interaction, we hypothesized that may ameliorate HIRI‐induced damage inhibiting axis activation. Using murine model found the salicylate acetyl‐3‐aminoethyl salicylic acid...
The mucosal epithelial barrier, the first line of immune defense, is vulnerable to allergens, pathogens, and inflammatory cytokines, contributing CRS development. Our previous studies found high interleukin-17A(IL-17A) expression correlated with severity low glucocorticoid efficacy. role IL-17A in disrupting nasal barrier leading remains unclear. We aimed investigate how promoting damage identify new treatment targets for CRS.
Hepatocellular carcinoma (HCC) is a malignancy with one of the worst prognoses. Long noncoding RNAs (lncRNAs) may be important in cancer development and serve as new biomarkers for diagnosis treatment various tumors, according to mounting research. The purpose this study was investigate expression INKA2-AS1 clinical importance HCC patients. TCGA database used obtain human tumor samples, while GTEx databases were gather normal samples. We screened differentially expressed genes (DEGs) between...
High-intensity focused ultrasound (HIFU) has been widely used in clinical settings and achieved suitable results the treatment of many cancerous or noncancerous diseases. However, liver cancer, because tumor is located deep within tissue, when penetrates it will inevitably produce sound energy attenuation. This attenuation limits reliability HIFU treatment, reduce efficacy HIFU, increase risk recurrence.Cationic microbubbles (CMB) were successfully linked with GPC3 HSV-TK plasmids, targeted...
Liver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). Kupffer cells (KCs) are the largest antigen-presenting cell (APC) group primary modulators of inflammation tissues. The vital role Notch1/Jagged1 pathway mouse OLT model has been reported, however, its potential therapeutic mechanism is unknown. Here, we made use short hairpin RNA-Jagged1 AAV-Jagged1 explore effects...
The present study aimed to investigate the effect and molecular mechanism of PKM2 small molecule agonist TEPP-46 on development methionine choline-deficient (MCD) diet-induced nonalcoholic steatohepatitis (NASH) in mice.
To investigate the role of endoplasmic reticulum (ER)-stress Kupffer cells (KCs) and KCs-derived tumor necrosis factor-α (TNF-α) in medicating apoptosis hepatic stellate cell (HSC).Sixty male SD rats were randomized into control group, model ER- stress depletion group KCs block (n=15). The 4 groups given intraperitoneal injections (twice a week for 8 weeks) normal saline (2 mg/kg); 40% CCl4 solution (in peanut oil, 2 mg/kg) tunicamycin (1 followed by clodronate liposomes (50 mg/kg),...
Abstract Cancer-associated fibroblasts (CAFs), integral components of the tumor microenvironment, play a pivotal role in proliferation, metastasis, and clinical outcomes. However, its specific roles Kidney Renal Clear Cell Carcinoma (KIRC) remain poorly understood. Employing established Seurat single-cell analysis pipeline, we identified 21 CAFs marker genes. Subsequently, prognostic signature consisting 6 genes ( RGS5 , PGF TPM2 GJA4 SEPT4 PLXDC1 ) was developed cohort through univariate...
Tumor recurrence after radiofrequency ablation (RFA) affects the survival rate of patients and limits its clinical application. around area may be related to thermal injury hepatocytes (HCs) tumor, but specific mechanism is still unclear. A liver cancer mouse model was established via RFA in C57BL/6 mice. Primary HCs Kupffer cells (KCs) were isolated cultured assess their sensitivity MTT assay. Flow cytometry used macrophage polarization. Furthermore, Western blotting co-immunoprecipitation...
Hepatocellular carcinoma (HCC) with high heterogeneity is one of the most frequent malignant tumors. However, there were no studies to create a clinical stage-related gene signature for HCC patients. Differentially expressed genes (DEGs) associated stage analyzed based on TCGA datasets. Functional enrichment analysis was carried out by use DEGs. Then, least absolute shrinkage and selection operator (LASSO) regression univariate Cox performed reduce overfit number further analysis. Next,...
The sputtering rate of Pt, Au, Fe and Co targets was researched they were 0.059 nm/s, 0.076 0.050 0.030nm/s respectively. A series magnetic multilayers prepared using the calibrated anomalous hall effect samples tested, Hall curve in line with expectations. appropriate for sample preparation. Suitable play a decisive role
Endocan is a dermatan sulfate proteoglycan, constituted of core protein with 165 amino acids and single chain covalently linked to the serine 137. It mainly expressed by activated endothelial cell regulated various cytokines growth factors. In hepatocellular carcinoma (HCC), expression endocan increases significantly, it can induce tumorigenesis promote tumor progression. involves in proliferation HCC cell, angiogenesis, metastasis immunity via variety complicated pathways, which cover...