A5100704923- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Hepatitis B Virus Studies
- Caveolin-1 and cellular processes
- Metabolism, Diabetes, and Cancer
- Lung Cancer Research Studies
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Mathematical Biology Tumor Growth
- Trace Elements in Health
- NF-κB Signaling Pathways
Central South University
2016-2025
Xiangya Hospital Central South University
2021-2025
Tsinghua University
2024-2025
Shandong First Medical University
2016-2024
Shandong Tumor Hospital
2016-2024
Chinese PLA General Hospital
2020-2024
Chinese People's Liberation Army
2022-2024
Chongqing Medical University
2023-2024
Second Affiliated Hospital of Chongqing Medical University
2023-2024
Dalian Medical University
2023-2024
Background: Cervical cancer is a major world health problem for women. Currently, research focuses on improving therapy cervical using various treatment options such as co-delivery of chemotherapeutic agents by nanocarriers. Purpose: The aim this study was to develop trans-activating transcriptional activator (TAT)-modified solid lipid nanoparticles (SLNs) paclitaxel (PTX) and α-tocopherol succinate-cisplatin prodrug (TOS-CDDP) (TAT PTX/TOS-CDDP SLNs) in order achieve synergistic antitumor...
Recent progress in studying copper-dependent targets and pathways the context of tumor treatment has provided new insights into therapeutic strategies leveraging disease vulnerabilities pharmacological manipulation intratumor copper transportation to improve chemotherapy. Here, we developed reactive oxygen species (ROS)-sensitive nanoparticles loaded with chaperone inhibitor DC_AC50 cisplatin(IV) prodrug. The released can promote a remarkable accumulation intracellular cisplatin through...
Natural killer (NK) cells play a major role in body's fighting against various types of cancers. Their infiltration the tumor microenvironment (TME) gastric cancer (GC) are significantly decreased, which has been reported as robust prognostic marker. However, causes leading to NK loss GC TME remains poorly understood.We constructed non-contact co-culturing system and humanized xenograft mice model detect influence on NK-92 or primary human viability by flow cytometry. Then through using...
Abstract Long noncoding RNAs (lncRNAs) play critical roles in cellular homeostasis. However, little is known about their effect developing rat brains with hypoxic-ischemic brain damage (HIBD). To explore the expression and function of lncRNA HIBD, we analyzed profiles lncRNAs (HI) sham control using microarray analysis. The results showed a remarkable difference between HI brains. A total 322 were found to be differentially expressed brains, compared control. Among these, BC088414 was one...
The aberrant expression of myotubularin-related protein 2 (MTMR2) has been found in some cancers, but little is known about the roles and clinical relevance. present study aimed to investigate relevance MTMR2 as well underlying mechanisms gastric cancer (GC). was examined 295 GC samples by using immunohistochemistry (IHC). correlation between clinicopathological features outcomes patients analyzed. regulating invasive metastatic capabilities cells were observed gain-and loss-of-function...
Abstract Aberrant expression of neuropilin and tolloid-like 2 (NETO2) has been observed during the progression some human carcinomas. However, pattern clinical relevance NETO2 in gastric cancer (GC) remain to be elucidated. In this study, we found that was higher GC tissues compared with paired non-cancerous tissues. Moreover, positively correlated stage, invasion depth, lymph node metastasis, tumor size, but inversely overall disease-free survival rates. Cox regression analysis identified...
Adipocyte enhancer binding protein 1 (AEBP1) is a transcriptional repressor that plays critical role in regulating adipogenesis. Recent studies have indicated AEBP1 might function as candidate oncogene and overexpressed several human malignancies. However, the of gastric cancer (GC) remains largely unknown. This study aimed to investigate expression pattern, prognostic significance biological explore underlying mechanism. We found both mRNA levels were significantly increased GC tissues....
Metastasis is the main cause of lung cancer‐related death. The tumor microenvironment greatly contributes to metastasis. Resistin, mainly secreted by tumor‐associated macrophages in tissues, a 12.5‐kDa cysteine‐rich secretory protein that found at significantly higher levels serum or plasma cancer patients compared with healthy controls. In this study, we explored expression and role resistin adenocarcinoma. Our study showed was strongly expressed adenocarcinoma tissues promoted migration...
Platinum-based chemotherapy is the first-line treatment of non-small cell lung cancer (NSCLC); it therefore important to discover biomarkers that can be used predict efficacy and toxicity this treatment. Four transporter genes are expressed in kidney, including organic cation 2 (OCT2), multidrug toxin extrusion 1 (MATE1), ATP-binding cassette subfamily B member (ABCB1), C (ABCC2), genetic polymorphisms these may alter adverse effects platinum drugs. This study aimed evaluate association...
Altered activities of long noncoding RNAs (lncRNAs) have been associated with cancer development, and lncRNA FOXD1-AS1 (FOXD1-AS1) is the antisense transcript gene encoding for FOXD1, known its role as an oncogene in several tumor types including glioma. However, differentiation progression glioma not well known.Expression profile chip qPCR were used to screen identify FOXD1-AS1. Glioma cells transfected siRNA or eukaryotic expression vector observe function vitro vivo. Dual luciferase...
Metastasis has become the main challenge for treatment of estrogen receptor alpha (ERα) negative breast cancer. Here, we found a correlation between miR-497 and estrogen-related (ERRα), nuclear overexpressed in ERα Targeted inhibition ERRα by si-RNA increased expression while overexpression inhibited expression. Further investigation showed that targeted binding to 3′UTR region ERRα. Luciferase assay ChIP confirmed directly regulated transcription miR-497, suggesting loss lowered level...
Levodopa remains the gold standard for treatment of Parkinson's disease, but its long-term use is associated with motor complications whose management still a significant challenge. Safinamide multimodal drug proven efficacy as an adjunct to levodopa. The objective this study was investigate and safety safinamide add-on levodopa in Chinese patients disease fluctuations. XINDI phase III, randomized, double-blind, placebo-controlled, multicenter study, 2-week screening period 16-week period....
Background and Purpose: Whether imaging parameters would independently predict stroke recurrence in low-risk minor ischemic (MIS) or transient attack (TIA) according to traditional score system (such as ABCD 2 score, which was termed on the basis of initials five factors: age, blood pressure, clinical features, duration, diabetes) remains unclear. We sought evaluate association between 1-year patients with TIA MIS different risk stratum stratified by score. Methods: included (National...