A5079953530- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Migraine and Headache Studies
- Vestibular and auditory disorders
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and genetic disorders
- Trigeminal Neuralgia and Treatments
- Moyamoya disease diagnosis and treatment
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Neuroscience and Neuropharmacology Research
- Hearing, Cochlea, Tinnitus, Genetics
- Intracranial Aneurysms: Treatment and Complications
- Olfactory and Sensory Function Studies
- Advanced Neuroimaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Long-Term Effects of COVID-19
- Extracellular vesicles in disease
- Venous Thromboembolism Diagnosis and Management
- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- Ophthalmology and Eye Disorders
Shanghai Jiao Tong University
2016-2025
Shanghai Ninth People's Hospital
2016-2025
Fujian Medical University
2011-2024
Soochow University
2022
Second Affiliated Hospital of Soochow University
2022
Capital Medical University
2021
Aluminum Corporation of China (China)
2020
Guangxi University
2019
Second Affiliated Hospital of Zhejiang University
2005-2013
Kiel University
2008-2012
Administration of exosomes derived from mesenchymal stromal cells (MSCs) could improve some neurologic conditions by transferring functional biomolecules to recipient cells. Furthermore, hypoxic progenitor exerted better therapeutic effects in organ injury through specific cargoes. However, there are no related reports about whether MSCs or hypoxia-preconditioned (PC-MSCs) prevent memory deficits Alzheimer disease (AD). In this study, the PC-MSCs were systemically administered transgenic...
Exosomes are lipid-bilayer enclosed nano-sized vesicles that transfer functional cellular proteins, mRNA and miRNAs. Mesenchymal stem cells (MSCs) derived exosomes have been demonstrated to prevent memory deficits in the animal model of Alzheimer's disease (AD). However, intravenously injected could be abundantly tracked other organs except for targeted regions brain. Here, we proposed use central nervous system-specific rabies viral glycoprotein (RVG) peptide target intravenously-infused...
The precuneus/posterior cingulate cortex, which has been associated with pain sensitivity, plays a pivotal role in the default mode network. However, information regarding migraine-related alterations resting-state brain functional connectivity network and local regional spontaneous neuronal activity is not adequate. This study used magnetic resonance imaging to acquire scans 22 migraineurs without aura healthy matched controls. Independent component analysis, data-driven method, was...
Migraine constitute a disorder characterized by recurrent headaches, and have high prevalence, socio-economic burden severe effects on quality of life. Our previous fMRI study demonstrated that some brain regions are functional alterations in migraineurs. As the function human is related to its structure, we further investigated white gray matter structural In current study, used surface-based morphometry, voxel-based morphometry diffusion tensor imaging analyses detect 32 migraineurs...
The neuropathological hallmarks of Alzheimer's disease (AD) include the presence extracellular amyloid-β peptide (Aβ) in form amyloid plaques and neuronal loss. Neural stem cell (NSC) is being scrutinized as a promising replacement therapy for various neurodegenerative diseases. However, unfavorable niche at site degenerative hostile to survival differentiation transplanted cells. Here, we undertook vitro vivo works examine whether designer self-assemble (DSP), which contains one functional...
Increasing evidence has suggested that the cerebellum is associated with pain and migraine. In addition, descending system of brainstem major site trigeminal processing modulation been discussed as a main player in pathophysiology Cerebellar structural changes migraineurs remain to be further investigated. Voxel-based morphometry (VBM) (50 controls, 50 without aura (MWoAs)) diffusion tensor imaging (DTI) (46 46 MWoAs) were used assess anatomical alterations MWoAs. We utilized spatially...
Objective: The platelet-to-lymphocyte ratio (PLR) is a new marker of atherosclerotic inflammation and has been identified as predictive factor in cardiovascular diseases, but its significance patients with acute ischaemic stroke (AIS) who have undergone intravenous thrombolysis (IVT) still unknown. Methods: Consecutive were treated IVT using recombinant tissue plasminogen activator (rtPA) for AIS included from May 2012 to August 2018. PLR was calculated according platelet lymphocyte counts...
Circulating microRNAs (miRNAs) have recently emerged as promising biomarkers for acute ischaemic stroke (AIS). However, the expression profiles of miRNAs in AIS patients receiving intravenous thrombolysis, and their associations with outcome not been investigated.In a prospective cohort study, total 84 patients, who received thrombolysis (21.4% combined reperfusion therapy) completed 3 month follow-up visits, were included. Favourable unfavourable outcomes defined modified Rankin Scale (mRS)...
Background and Purpose: Acute ischemic stroke (AIS) is a serious threat to the life health of middle-aged elderly people. Mechanical thrombectomy offers advantages rapid recanalization, but response patients this treatment varies greatly. This study investigated risk factors for futile recanalization in AIS after through multivariate analyses. Methods: A retrospective was conducted with anterior circulation occlusion from derivation cohort validation who underwent reperfusion defined as...
Migraine is a multifaceted primary headache disorder. In neuroimaging of migraine, fMRI has been used to elucidate pathophysiology or monitor treatment effects. The current literature, however, highly heterogeneous regarding reported variables and methodologies. This begets lack comparability complicates synthesis results across studies. We developed framework for standardized reporting studies in migraine. Experts on migraine were identified from the literature subjected structured...
Somatic Symptom Disorder (SSD) is a condition often linked to excessive health anxiety and somatic symptoms. In recent years, studies have found associations between the cerebellum various mental illnesses, including SSD. However, microstructure of cerebellar subregions in SSD using diffusion magnetic resonance imaging has not been fully defined. This cross-sectional study, that included 30 patients age- gender-matched healthy controls investigate imaging. diagnosis followed DSM-5 criteria,...
Abstract Background Migraine is a severe and disabling brain disorder, the exact neurological mechanisms remain unclear. Migraineurs have altered pain perception, headache attacks disrupt their sensory information processing sensorimotor integration. The functional connectivity of sub-regions areas with other cortex associated migraine needs further investigation. Methods Forty-eight migraineurs without aura during interictal phase 48 age- sex-matched healthy controls underwent resting-state...
Background: Patients who experienced an ischemic stroke are at risk for cognitive impairment. Quantified Ginkgo biloba extract EGb 761® has been used to treat dysfunction, functional impairment and neuropsychiatric symptoms in mild dementia. Objectives: To assess the cognitive-related effects of treatment patients after acute stroke, as well feasibility patient selection outcome measures. Methods: We conducted a randomized, multicentric, open-label trial 7 centers China. scoring 20 or lower...
Minocycline protects animals against cerebral ischemia by inhibiting inflammation. To determine whether minocycline PC12 cells from in vitro ischemic-like injury and affects pro-inflammatory 5-lipoxygenase activation, the cell viability translocation to nuclear membrane were observed after oxygen-glucose deprivation (OGD). We found that OGD reduced viability, which was attenuated inhibitor caffeic acid. 5-Lipoxygenase protein detected immunohistochemical Western blot analyses. induced...
Abstract Migraines are a common and undertreated disease often have psychiatric comorbidities; however, the abnormal mechanism of emotional processing in migraine patients has not been well clarified. This study sought to investigate different brain functional activation neutral, positive negative stimuli between healthy subjects. Twenty-six adults with migraines 26 adults, group-matched for sex age, participated this experiment. Although there were no significant differences two groups...
Long-term headache attacks may cause human brain network reorganization in patients with migraine. In the current study, we calculated topologic properties of functional networks based on Brainnetome atlas using graph theory analysis 29 female migraineurs without aura (MWoA) and age-matched healthy controls. Compared controls, MWoA exhibited that altered, nodal centralities decreased/increased some areas. particular, right posterior insula left medial superior occipital gyrus significantly...
Levodopa remains the gold standard for treatment of Parkinson's disease, but its long-term use is associated with motor complications whose management still a significant challenge. Safinamide multimodal drug proven efficacy as an adjunct to levodopa. The objective this study was investigate and safety safinamide add-on levodopa in Chinese patients disease fluctuations. XINDI phase III, randomized, double-blind, placebo-controlled, multicenter study, 2-week screening period 16-week period....