A5002366827- Pain Mechanisms and Treatments
- Migraine and Headache Studies
- Pain Management and Placebo Effect
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Motor Control and Adaptation
- EEG and Brain-Computer Interfaces
- Vestibular and auditory disorders
- Musculoskeletal pain and rehabilitation
- Heart Rate Variability and Autonomic Control
- Menstrual Health and Disorders
- Olfactory and Sensory Function Studies
- Advanced MRI Techniques and Applications
- Myofascial pain diagnosis and treatment
- Neuroscience and Neural Engineering
- Pediatric Pain Management Techniques
- Hearing, Cochlea, Tinnitus, Genetics
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Cardiovascular Syncope and Autonomic Disorders
- Hearing Loss and Rehabilitation
- Trigeminal Neuralgia and Treatments
- Neuroscience and Music Perception
- Psychosomatic Disorders and Their Treatments
- Music Therapy and Health
Taipei Veterans General Hospital
2009-2025
National Yang Ming Chiao Tung University
2014-2025
National Yang Ming University Hospital
2012-2020
VA Office of Research and Development
2008-2013
Center for Neurosciences
2007
University System of Taiwan
2006
Aalborg University
2000-2002
Primary dysmenorrhea (PDM) is the most prevalent gynecological disorder for women in reproductive age. PDM patients suffer from lower abdominal pain that starts with onset of menstrual flow. Prolonged nociceptive input to central nervous system can induce functional and structural alterations throughout system. In PDM, a chronic viscero-nociceptive drive cyclic nature, indications sensitization altered brain metabolism suggest substantial reorganization. Previously, we hypothesized...
Dysmenorrhea is the most prevalent gynecological disorder in women of child-bearing age. associated with central sensitization and functional structural changes brain. Our recent brain morphometry study disclosed that dysmenorrhea trait-related abnormal gray matter (GM) changes, even absence menstrual pain, indicating adolescent vulnerable to pain. Here we report rapid state-related morphological ie, between pain pain-free states, dysmenorrhea. We used T1-weighted anatomic magnetic resonance...
Low-intensity low-frequency electrostimulation delivered within a myofascial trigger point (MTP) has been used as intervention to deactivate MTPs. The therapeutic effect suggested be due peripheral mechanisms. However, nonpainful stimuli are also known reduce simultaneous pain through central effects. primary objective of the present study was assess if modulation occurs after with low-intensity an MTP. We hypothesized that induces inhibition via periaqueductal gray (PAG).Twenty-four...
Summary IBS patients and controls achieve comparable placebo analgesia upon experimentally induced rectal pain. The during the visceral pain involves enhanced brain activities relating to affect/cognition in patients. Placebo is a psychosocial context effect that rarely studied Patients with irritable bowel syndrome (IBS) exhibit hyperalgesia heightened affective/cognitive region activation stimuli. Psychological factors alter pattern, these changes are more pronounced Expectation...
Background Migraine with visual aura (MA) is associated distinct disturbances preceding migraine attacks, but shares other deficits in between attacks without (MO). Here, we seek to determine if abnormalities specific interictal MA patients exist functional brain connectivity of intrinsic cognitive networks. In particular, these networks are involved top-down modulation processing. Methods Using resting-state magnetic resonance imaging, whole-brain maps were derived from seeds placed the...
Objectives To investigate the structural changes of hippocampus and amygdala their relationships with migraine frequency prognosis. Methods Hippocampus volumes were measured by 3-T brain magnetic resonance imaging (MRI) in 31 controls 122 patients who categorized into eight groups headache frequency: group 1 (1-2 days/month), 2 (3-4), 3 (5-7), 4 (8-10), 5 (11-14), 6 (15-19), 7 (20-24), 8 (25-30). Headache was reassessed years later a reduction ≥50% regarded good outcome. Results fluctuated...
Abstract Inhibiting the responses to irrelevant stimuli is an essential component of human cognitive function. Pre-attentive auditory sensory gating (SG), attenuated neural activation second identical stimulus, has been found be related performance higher-hierarchical brain However, it remains unclear whether other cortical regions, such as somatosensory cortex, also possess similar characteristics, or if a relationship modality-specific. This study used magnetoencephalography record...
Despite evidently distinct symptoms, tension-type headache (TTH) and migraine are highly comorbid exhibit many similarities in clinical practice. The purpose of this study was to investigate whether both types headaches similar brain morphology.Consecutive patients with TTH age- sex-matched healthy controls were enrolled for magnetic resonance imaging examination. Patients excluded if they reported any features or associated symptoms migraine. Changes gray matter (GM) volume diagnosis (TTH...
Abstract Background Bihemispheric transcranial direct current stimulation (tDCS) of the primary motor cortex (M1) can simultaneously modulate bilateral corticospinal excitability and interhemispheric interaction. However, how tDCS affects subacute stroke recovery remains unclear. We investigated effects bihemispheric on in patients. Methods enrolled inpatients who had first-ever ischemic at subcortical regions moderate-to-severe baseline Fugl-Meyer Assessment Upper Extremity (FMA-UE) score...
Visceral pain/discomfort is the cardinal complaints and treatment targets for functional gastrointestinal disorders (FGID). However, effective such pain limited often associated with high placebo effects. The mechanisms of effects in visceral are unclear. We used neuroimaging to study central representations effect its anticipation during esophageal healthy adults. Fourteen subjects were enrolled. Pain extent, psychophysical inventories [Pain Catastrophizing Scale (PAS), visual analogue...
Background Previous voxel- or surface-based morphometric analysis studies have revealed alterations in cortical structure patients with chronic migraine, yet inconsistent results. The discrepancies may be derived partly from the sample heterogeneity. Employing both methods a clinically homogenous group provide clearer view. Methods Structural MRI data 30 prevention-naïve migraine without medication overuse headache history of major depression and healthy controls were analyzed. Vertex-wise...
The neurobiological mechanisms driving the ictal-interictal fluctuations and chronification of migraine remain elusive. We aimed to construct a composite genetic-microRNA model that could reflect dynamic perturbations disease course inform pathogenesis migraine. prospectively recruited four groups participants, including interictal episodic (i.e., headache-free for > 72 hrs apart from prior subsequent attacks), ictal during moderate severe chronic migraine, controls in discovery cohort....
Migraine is a multifaceted primary headache disorder. In neuroimaging of migraine, fMRI has been used to elucidate pathophysiology or monitor treatment effects. The current literature, however, highly heterogeneous regarding reported variables and methodologies. This begets lack comparability complicates synthesis results across studies. We developed framework for standardized reporting studies in migraine. Experts on migraine were identified from the literature subjected structured...
Enhanced stress responsiveness is an important pathophysiological factor in irritable bowel syndrome (IBS), suggesting the presence of a dysregulated hypothalamic-pituitary-adrenal (HPA) axis. A possible mechanism involves maladaption feedback HPA We hypothesized that hippocampus, key brain region providing inhibitory to axis, would exhibit reduced excitatory glutamatergic neurotransmission and N-acetyl-aspartate (NAA; marker neuronal integrity) levels IBS patients.In this preliminary study,...
Myofascial trigger points (MTrPs) are a highly prevalent source of musculoskeletal pain. Prolonged ongoing nociceptive input from MTrPs may lead to maladaptive changes in the central nervous system. It remains, however, unknown whether pain is associated with brain atrophy. In addition, stress, which contribute formation MTrPs, also known affect structures. Here, we address structural occur patients chronic originating and such related or stress.Voxel-based morphometry was used compare...
Abstract While the automatic inhibitory function of human cerebral cortex has been extensively investigated by means electrophysiological recordings, corresponding modulating neurochemical mechanisms remain unclear. We aimed to examine whether primary somatosensory (SI) and motor cortical (MI) is associated with endogenous GABA levels. Eighteen young participants received paired-pulse single-pulse electrical stimulation median nerve during magnetoencephalographic recordings. The SI sensory...
Objectives Chronic migraine (CM) is a prevalent and devastating disorder with limited therapeutic options. This study explored the efficacy of 10 mg/d flunarizine for CM prophylaxis as compared 50 topiramate. Methods We conducted prospective, randomized, open-label, blinded-endpoint trial. Patients were randomized to topiramate treatment. The primary outcomes assessed reductions in total numbers headache days after 8 weeks Secondary acute abortive medication intake tablets taken, 50%...