A5073387462- Migraine and Headache Studies
- Neurological Complications and Syndromes
- Moyamoya disease diagnosis and treatment
- Trigeminal Neuralgia and Treatments
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Neuroscience of respiration and sleep
- Neurological and metabolic disorders
- Sympathectomy and Hyperhidrosis Treatments
- Ophthalmology and Eye Disorders
- Pain Mechanisms and Treatments
- Vestibular and auditory disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Functional Brain Connectivity Studies
- Vagus Nerve Stimulation Research
- Heart Rate Variability and Autonomic Control
- Psychosomatic Disorders and Their Treatments
- Head and Neck Surgical Oncology
- Parkinson's Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Cerebrovascular and Carotid Artery Diseases
National Yang Ming Chiao Tung University
2016-2025
Taipei Veterans General Hospital
2016-2025
Chung Shan Medical University Hospital
2009-2025
Chung Shan Medical University
2013-2025
Keio University Hospital
2025
Ministry of Health and Welfare
2022
Bridge University
2022
Academia Sinica
2022
National Chung Cheng University
2022
National Academy of Medicine
2016-2021
To investigate the evolution and clinical significance of vasoconstriction on magnetic resonance angiography (MRA) in patients with reversible cerebral syndromes (RCVS).Patients RCVS were recruited followed up MRA examinations until normalization or for 6 months. The severity major arterial segments (M1, M2, A1, A2, P1, P2, basilar artery) was scored a 5-point scale: 0 (0-<10%), 1 (10-<25%), 2 (25-<50%), 3 (50-<75%), 4 (> =75%). Subjects at least segment score > =2 eligible study. Initial...
Objectives: To investigate the clinical pictures of patients with recurrent thunderclap headaches unknown etiology and to field-test two relevant International Classification Headache Disorders , 2nd edition (ICHD-II) criteria, i.e., primary headache (Code 4.6) benign (or reversible) angiopathy CNS 6.7.3). Methods: We prospectively recruited presenting idiopathic from a hospital-based clinic. Detailed histories, neurologic examinations, MRIs magnetic resonance angiographies (MRAs) were...
Abstract Objective Reversible cerebral vasoconstriction syndromes (RCVS) are characterized by thunderclap headaches and reversible vasoconstrictions. No systematic studies on hemodynamics have been published. Methods Patients with RCVS were consecutively recruited. Sequential transcranial color‐coded sonography performed the middle artery (MCA) for 3 months. Mean flow velocities (V MCA ) Lindegaard Index (LI) recorded compared those of controls. Results Thirty‐two patients (all female;...
Reversible cerebral vasoconstriction syndromes (RCVS) are characterized by recurrent acute severe headaches, namely thunderclap and multifocal segmental vasoconstrictions. Interest has arisen in the definitions, clinical presentations, differential diagnoses, risk factors complications of RCVS. This article will comprehensively review milestone monographs latest research work addressing these issues. Studies that have focused on relationship between RCVS headache be detailed. We also discuss...
In Brief Vagus nerve stimulation has recently been reported to improve symptoms of migraine. Cortical spreading depression is the electrophysiological event underlying migraine aura and a trigger for headache. We tested whether vagus inhibits cortical explain its antimigraine effect. Unilateral was delivered either noninvasively through skin or directly by electrodes placed around nerve. Systemic physiology monitored throughout study. Both noninvasive transcutaneous invasive direct...
Spontaneous intracranial hypotension results from cerebrospinal fluid leakage. Currently, the treatment of choice for spontaneous is epidural blood patch, which has a variable response rate and no clear outcome predictors. This study aimed to identify predictors first targeted patch in patients with hypotension. We reviewed cases who received at our hospital between 1 January 2007 July 2014. The measure was response. analysed demographics, clinical manifestations, neuroimaging findings...
Abstract Spreading depolarization is a wave of neuronal and glial depolarization. Within minutes after spreading depolarization, the hemichannel pannexin 1 (PANX1) opens forms pore complex with ligand-gated cation channel P2X7, allowing release excitatory neurotransmitters to sustain activate neuroinflammation. Here, we explore hypothesis that P2X7–PANX1 critical determinant susceptibility important consequences for neuroinflammation trigeminovascular activation. We found genetic loss...
Objective To evaluate human glymphatics and meningeal lymphatics noninvasively. Methods This prospective study implemented 3‐dimensional (3D) isotropic contrast‐enhanced T2 fluid‐attenuated inversion recovery (CE‐T2‐FLAIR) imaging with a 3T magnetic resonance machine to cerebral in patients reversible vasoconstriction syndrome (RCVS) (n = 92) or without 90) blood–brain barrier (BBB) disruption diseased control group cluster headache 35). The contrast agent gadobutrol (0.2mmol/kg [0.2ml/kg])...
Objective This study was undertaken to investigate migraine glymphatic and meningeal lymphatic vessel (mLV) functions. Methods Migraine patients healthy controls (HCs) were prospectively recruited between 2020 2023. Diffusion tensor image analysis along the perivascular space (DTI‐ALPS) index for glymphatics dynamic contrast‐enhanced magnetic resonance imaging parameters (time peak [TTP]/enhancement integral [EI]/mean time enhance [MTE]) para‐superior sagittal (paraSSS)‐mLV or paratransverse...
Abstract Spreading depolarization (SD), the underlying mechanism of migraine aura, may trigger opening pannexin 1 (PANX1) pore to sustain cortical neuroinflammatory cascades involved in genesis headache. Yet, SD-evoked neuroinflammation and trigeminovascular activation remains incompletely understood. We characterized identity inflammasome activated following PANX1 opening. Pharmacological inhibitors targeting or NLRP3 as well genetic ablation Nlrp3 Il1b were applied investigate molecular...
Background The radiology, obstruction, symptoms and exposure (ROSE) criteria provide a standardised approach for identifying the “COPD–bronchiectasis (BE) association.” However, clinical implications outcomes of COPD–BE association in East Asian populations remain unclear. Our study applied ROSE to assess prevalence, impact an cohort, compared that cohort with nonsmoking BE patients fixed airflow obstruction (FAO) those without FAO. Methods An integrated analysis was conducted within...
Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by recurrent thunderclap headaches and reversible vasoconstrictions. RCVS more common than previously thought should be differentiated from aneurismal subarachnoid hemorrhage. can spontaneous or evoked pregnancy exposure to vasoactive substances. Patients tend middle-aged women but pediatric patients have been seen. Up 80% of sufferers identifiable triggers. Thunderclap recur daily last for a period around 2 weeks, while...
Background An association between restless legs syndrome and migraine has been reported recently. The clinical correlates impact of comorbidity (RLS) are not fully described in patients with migraine. Objectives To investigate the frequency RLS among different primary headache disorders, its patients. Methods Consecutive migraine, tension-type (TTH) cluster (CH) were recruited a clinic. Each patient completed Migraine Disability Assessment (MIDAS) questionnaire, Hospital Anxiety Depression...
We aimed to investigate whether reversible cerebral vasoconstriction syndrome (RCVS) could recur and identify the potential predictors of recurrence in a large cohort patients.This study followed 210 patients with RCVS hospital-based headache center from 2000 2012. All were regularly up by telephone after remission for particularly asked return our hospital immediately if they developed new acute, severe (i.e., thunderclap-like) headaches. Sequential neuroimaging studies used determine had...
The spatial distribution and clinical correlation of cerebrospinal fluid leakage after lumbar puncture have not been determined. Adult in-patients receiving diagnostic punctures were recruited prospectively. Whole-spine heavily T2-weighted magnetic resonance myelography was carried out to characterize post-lumbar spinal leakages. Maximum rostral migration defined as the distance between most segment with level puncture. Eighty patients (51 female/29 male, mean age 49.4 ± 13.3 years)...
Background Vagus nerve stimulation (VNS) was recently found to inhibit cortical spreading depression (CSD), the underlying mechanism of migraine aura, through activation nucleus tractus solitarius (NTS), locus coeruleus (LC) and dorsal raphe (DRN). The molecular mechanisms effect VNS on CSD in these nuclei remain be explored. We hypothesized that may activate glutamate receptor-mediated tropomyosin kinase B (TrkB) signaling NTS, thereby facilitating noradrenergic serotonergic...
Objectives: To study the clinical profiles, imaging findings and outcomes field test diagnostic criteria proposed by International Classification of Headache Disorders, 2nd edition (ICHD-II) in patients with headache associated sexual activity (HSA). Methods: We recruited 30 (16 men, 14 women, mean age at onset 40.2 ± 10.0 years) a clinic from 2004 to 2009. None had neurological deficits onset. Results: Twenty (67%) secondary causes, including one subarachnoid hemorrhage, basilar artery...
To examine the extent and to identify relevant predictors of headache disabilities in adolescents.Headaches are common adolescents but their impact related factors have not been extensively studied adolescent communities.We recruited surveyed 3963 students aged 13-15 from 3 middle schools using self-administered questionnaires. The questionnaires were used make assessments: (1) headaches diagnosed a validated questionnaire; (2) evaluated 6-question Pediatric Migraine Disability Assessment;...
Background Reversible cerebral vasoconstriction syndrome (RCVS) could be complicated by ischemic events. Hypothetical mechanisms of RCVS involve endothelial dysfunction and sympathetic overactivity, both which were reported to related brain-derived neurotrophic factor (BDNF). The study investigated the association between functional BDNF Val66Met polymorphism RCVS. Methods Patients with controls prospectively recruited genotyped for polymorphism. Magnetic resonance angiography (MRA)...