Abstract Objective The neuromodulatory effects of focused ultrasound (FUS) have been demonstrated in animal epilepsy models; however, the safety and efficacy FUS humans with not well established. Patients drug‐resistant (DRE) undergoing stereo‐electroencephalography (SEEG) provide an opportunity to investigate humans. Methods DRE SEEG for localization seizure onset zone (SOZ) were prospectively enrolled. was delivered SOZ using a neuronavigation‐guided system (ceiling spatial‐peak...

Some researchers have suggested that the default mode network (DMN) plays an important role in pathological mechanisms of Alzheimer's disease (AD). To examine whether cortical activities DMN regions show significant difference between mild AD from cognitive impairment (MCI), electrophysiological responses were analyzed 21 (AD) and (MCI) patients during eyes closed, resting-state condition. The spectral power functional connectivity estimated using a minimum norm estimate (MNE) combined with...

Objectives To investigate the structural changes of hippocampus and amygdala their relationships with migraine frequency prognosis. Methods Hippocampus volumes were measured by 3-T brain magnetic resonance imaging (MRI) in 31 controls 122 patients who categorized into eight groups headache frequency: group 1 (1-2 days/month), 2 (3-4), 3 (5-7), 4 (8-10), 5 (11-14), 6 (15-19), 7 (20-24), 8 (25-30). Headache was reassessed years later a reduction ≥50% regarded good outcome. Results fluctuated...

Despite evidently distinct symptoms, tension-type headache (TTH) and migraine are highly comorbid exhibit many similarities in clinical practice. The purpose of this study was to investigate whether both types headaches similar brain morphology.Consecutive patients with TTH age- sex-matched healthy controls were enrolled for magnetic resonance imaging examination. Patients excluded if they reported any features or associated symptoms migraine. Changes gray matter (GM) volume diagnosis (TTH...

The electrophysiological signature of resting state oscillatory functional connectivity within the default mode network (DMN) during spike-free periods in temporal lobe epilepsy (TLE) remains unclear. Using magnetoencephalographic (MEG) recordings, this study investigated how DMN was altered TLE, and we examined effect lateralized TLE on connectivity. Sixteen medically intractable patients 22 controls participated study. Whole-scalp 306-channel MEG epochs without interictal spikes generated...

Fibromyalgia (FM) is a disabling chronic pain syndrome with unknown pathophysiology. Functional magnetic resonance imaging studies on FM have suggested altered brain connectivity between the insula and default mode network (DMN). However, this change has not been characterized through direct neural signals for exploring embedded spectrotemporal features pertinent clinical relevance.We recorded resting-state magnetoencephalographic activities of 28 patients age- sex-matched controls, analyzed...

Finding a biomarker to diagnose migraine remains significant challenge in the headache field. Migraine patients exhibit dynamic and recurrent alterations brainstem-thalamo-cortical loop, including reduced thalamocortical activity abnormal habituation during interictal phase. Although these insights into pathophysiology have been valuable, they are not currently used clinical practice. This study aims evaluate potential of Artificial Neural Networks (ANNs) distinguishing from healthy...

Severe asymptomatic stenosis of the internal carotid artery (ICA) leads to increased incidence mild cognitive impairment (MCI) likely through silent embolic infarcts and/or chronic hypoperfusion, but brain dysfunction is poorly understood and difficult diagnose. Thirty cognitively intact subjects with asymptomatic, severe (≥ 70%), unilateral ICA were compared 30 healthy controls, matched for age, sex, cardiovascular risk factors education level, on a battery neuropsychiatric tests,...

The magnetic equivalent (MMNm) of mismatch negativity may reflect auditory discrimination and sensory memory. To study whether temporal lobe epilepsy (TLE) affects automatic central auditory-change processing, we recorded magnetoencephalographic (MEG) responses to standard duration-deviant sounds in 12 TLE patients age-matched controls, repeated MEG measurement 8 6–30 months following surgery 6 controls 3–8 after their first measurement. We compared the MMNm between also evaluated intertrial...

Background Brain excitability is changed in migraine but not fully characterized yet. This study explored if somatosensory gating altered and linked to chronification. Methods Paired electrical stimuli were delivered the left index fingers of 21 patients with without aura (MO), 22 chronic (CM), 36 controls. The first second responses paired obtained from contralateral primary (cSI), secondary (cSII) ipsilateral (iSII) cortices compute ratios (second vs. response strengths). Results cSI...

OBJECTIVE The semiology of cingulate gyrus epilepsy is varied and may involve the paracentral area, adjacent limbic system, and/or orbitofrontal gyrus. Invasive electroencephalography (iEEG) recording usually required for patients with deeply located epileptogenic foci. This paper reports on authors’ experiences in diagnosis surgical treatment focal originating METHODS Eighteen (median age 24 years, range 5–53 years) a mean seizure history 23 years (range 2–32 were analyzed retrospectively....

Migraine has complex pathophysiological characteristics and episodic attacks. To decipher the cyclic neurophysiological features of migraine attacks, in this study, we compared neuronal excitability brainstem primary somatosensory (S1) region between phases for 30 consecutive days two patients with migraine.Both underwent EEG recording event-related potentials paired-pulse paradigms days. The cycle was divided into following phases: 24-48 h before headache onset (Pre2), within 24 (Pre1),...

To identify and validate the neural signatures of resting-state oscillatory connectivity for chronic migraine (CM), we used machine learning techniques to classify patients with CM from healthy controls (HC) other pain disorders. The cross-sectional study obtained magnetoencephalographic data 240 participants (70 HC, 100 CM, 35 episodic [EM], fibromyalgia [FM]). Source-based relevant cortical regions was calculated determine intrinsic at 1-40 Hz. A classification model that employed a...

Abstract Tension-type headache (TTH) and migraine are both common types of headaches. Despite distinct symptoms, TTH highly comorbid exhibit many clinical similarities. This study enrolled consecutive patients with age- sex-matched healthy controls to investigate whether similar in brain excitability change assessed by magnetoencephalography. Patients were excluded if they reported any features or associated symptoms migraine. In response paired-pulse electrical stimulations, the gating...

To examine whether the modulating evoked cortical oscillations could be brain signatures among patients with chronic migraine, we investigated modulation using an electroencephalogram machine learning techniques.We directly record activity during nonpainful, painful, and repetitive painful electrical stimulation tasks. Cortical for experimental pain habituation processing was analyzed used to differentiate migraine from healthy controls a validated machine-learning model.This study included...

Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterised by motor abnormalities. Many non-demented patients with PD have cognitive impairment especially in executive functions. Using magnetoencephalographic (MEG) recording combined event-related desynchronisation/synchronisation (ERD/ERS) analysis, we investigated cortical functions during Go/NoGo task and matched healthy subjects. had longer reaction time the Go condition higher error ratio both NoGo conditions. The...

Background. Recovery of upper limb function post-stroke can be partly predicted by initial motor function, but the mechanisms underpinning these improvements have yet to determined. Here, we sought identify neural correlates recovery using longitudinal magnetoencephalography (MEG) assessments in subacute stroke survivors. Methods. First-ever, subcortical ischemic survivors with unilateral mild moderate hand paresis were evaluated at 3, 5, and 12 weeks after a finger-lifting task MEG....