A5067455070- Pain Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Mitochondrial Function and Pathology
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Alzheimer's disease research and treatments
- Medical Image Segmentation Techniques
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Neurological disorders and treatments
- Brain Tumor Detection and Classification
- Neural and Behavioral Psychology Studies
- Metabolism, Diabetes, and Cancer
- EEG and Brain-Computer Interfaces
- Neuroinflammation and Neurodegeneration Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Transcranial Magnetic Stimulation Studies
- Sirtuins and Resveratrol in Medicine
- Peripheral Neuropathies and Disorders
- Digital Marketing and Social Media
- Advanced MRI Techniques and Applications
- Action Observation and Synchronization
- Advanced Glycation End Products research
- Zebrafish Biomedical Research Applications
National Yang Ming Chiao Tung University
2015-2025
Fu Jen Catholic University
2016-2025
National Taiwan University Hospital
2001-2023
National Taiwan University
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Liechtenstein Institute
2023
National Yang Ming University Hospital
2011-2020
National Tsing Hua University
2012
Chinese Culture University
2010-2011
Nowadays, chatbots is one of the fast rising artificial intelligence (AI) trend relates to utilisation applications that interact with users in a conversational format and mimic human conversation. Chatbots allow business enhance customer experiences fulfil expectations through real-time interactions e-commerce environment. Therefore, factors influence consumer's trust critical. This study demonstrates model empirically investigate perception by questionnaire from self-reported approach...
Abstract Huntington's disease (HD) is an autosomal dominant neurodegenerative caused by a CAG trinucleotide expansion in exon 1 of the Huntingtin (Htt) gene. We show herein that HD transgenic mouse model (R6/2), daily administration CGS21680 (CGS), A 2A adenosine receptor (A ‐R)‐selective agonist, delayed progressive deterioration motor performance and prevented reduction brain weight. 3D‐µMRI analysis revealed CGS reversed enlarged ventricle‐to‐brain ratio R6/2 mice, with particular...
We apply an information-theoretic cost metric, the symmetrized Kullback-Leibler (sKL) divergence, or J-divergence, to fluid registration of diffusion tensor images. The difference between tensors is quantified based on sKL-divergence their associated probability density functions (PDFs). Three-dimensional DTI data from 34 subjects were fluidly registered optimized target image. To allow large image deformations but preserve topology, we regularized flow with a large-deformation diffeomorphic...
Huntington's disease (HD) is a neurodegenerative caused by the expansion of CAG trinucleotide repeat in exon 1 huntingtin (HTT) gene. Here, we report that transcript peroxisome proliferator-activated receptor-γ (PPARγ), transcription factor critical for energy homeostasis, was markedly downregulated multiple tissues mouse model (R6/2) HD and lymphocytes patients. Therefore, downregulation PPARγ seems to be pathomechanism HD. Chronic treatment R6/2 mice with an agonist (thiazolidinedione,...
Background Huntington's disease (HD) is a neurodegenerative caused by CAG trinucleotide expansion in the Huntingtin (Htt) gene. The expanded repeats are translated into polyglutamine (polyQ), causing aberrant functions as well aggregate formation of mutant Htt. Effective treatments for HD yet to be developed. Methodology/Principal Findings Here, we report novel dual-function compound, N6-(4-hydroxybenzyl)adenine riboside (designated T1-11) which activates A2AR and major adenosine transporter...
The authors evaluated epidermal nerve density (END) and thermal thresholds in 18 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). END of CIDP were lower than those controls (4.5 ± 2.9 vs 10.5 3.9 fibers/mm, p < 0.001). Reduced associated autonomic symptoms. Thermal elevated (88.2% for warm stimuli 70.6% cold stimuli). Patients have small-fiber sensory neuropathies.
Huntington's disease (HD) is an autosomal dominant neurodegenerative caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. Using two mouse models of HD, we demonstrate that urea cycle deficiency characterized hyperammonemia, high blood citrulline and suppression enzymes prominent feature HD. The resultant ammonia toxicity might exacerbate neurological deficits Suppression C/EBPα, crucial transcription factor for enzymes, appears to mediate We found presence mutant Htt, C/EBPα...
Huntington's disease (HD) is an autosomal dominant neurodegenerative caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. The resultant mutant Htt protein (mHtt) forms aggregates brain and several peripheral tissues (e.g. liver) causes devastating neuronal degeneration. Metabolic defects resulting from also contribute to HD pathogenesis. Simultaneous improvement of both CNS thus most effective therapeutic strategy highly desirable. We earlier showed that agonist A2A...
Persistent neuropathic pain due to peripheral nerve degeneration in diabetes is a stressful symptom; however, the underlying neural substrates remain elusive. This study attempted explore neuroanatomical of thermal hyperalgesia and burning diabetic cohort pathologically proven cutaneous (the painful group). By applying noxious 44°C heat stimuli right foot provoke symptoms, brain activation patterns were compared with those healthy control subjects patients similar degree but without painless...
Abstract Practice of tasks in an interleaved order generally induces superior learning compared with practicing a repetitive order, phenomenon known as the contextual‐interference (CI) effect. Increased neural activity during over practice has been associated beneficial effects CI. Here, we used psychophysiological interaction (PPI) analysis to investigate whether connectivity dorsal premotor (PM) and dorsolateral prefrontal (DLPFC) cortices changes when motor sequences are acquired through...
Huntington's disease is a neurodegenerative resulting from CAG (glutamine) trinucleotide expansion in exon 1 of the Huntingtin (Htt) gene. The role striatum-enriched A2A adenosine receptor (A2A-R) has attracted much attention lately. In present study, we found that expression mutant Htt with expanded poly(Q) significantly reduced transcript levels endogenous A2A-R PC12 cells and primary striatal neurons. Cotransfection various promoter constructs gene an construct poly(Q)-expanded revealed...
A major challenge in neuroscience is finding which genes affect brain integrity, connectivity, and intellectual function. Discovering influential holds vast promise for neuroscience, but typical genome-wide searches assess approximately one million genetic variants one-by-one, leading to intractable false positive rates, even with samples of subjects. Even more the question interact how they work together connectivity. Here, we report a novel approach that discovers contribute wiring fiber...
The quest to identify genes that influence disease is now being extended find affect biological markers of disease, or endophenotypes. Brain images, in particular, provide exquisitely detailed measures anatomy, function, and connectivity the living human brain, have identified characteristic features psychiatric neurological disorders. emerging field imaging genomics discovering important genetic variants associated with brain structure which turn risk fundamental cognitive processes....