A5007756770- Migraine and Headache Studies
- Diet and metabolism studies
- Trigeminal Neuralgia and Treatments
- Functional Brain Connectivity Studies
- Vestibular and auditory disorders
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Olfactory and Sensory Function Studies
- Sympathectomy and Hyperhidrosis Treatments
- Glioma Diagnosis and Treatment
- Biochemical effects in animals
- Mitochondrial Function and Pathology
- Neuroscience of respiration and sleep
- Ophthalmology and Eye Disorders
- Parkinson's Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
- Nutritional Studies and Diet
- Pain Mechanisms and Treatments
- Amino Acid Enzymes and Metabolism
- Pharmacological Effects and Toxicity Studies
- Brain Metastases and Treatment
- Metabolism and Genetic Disorders
- Complementary and Alternative Medicine Studies
- Cerebral Palsy and Movement Disorders
Sapienza University of Rome
2015-2025
Policlinico San Matteo Fondazione
2024-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2025
European Gravitational Observatory
2021-2024
University of Pavia
2007-2024
University of Bergamo
2023
Università Campus Bio-Medico
2019-2021
Weatherford College
2020
Centre Hospitalier Universitaire de Liège
2020
Università Cattolica del Sacro Cuore
2020
Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects large proportion of women. Due to its heterogeneity, the best diagnostic strategy has been matter contention. Since 1990 scientific societies in field human reproduction have tried define pivotal criteria for diagnosis PCOS. The consensus Rotterdam included presence hyperandrogenism, oligo/anovulation, and polycystic ovarian morphology (PCOM), now updated evidence based 2018 2023 International Guideline endorsed by...
Background and purpose Ketogenesis is a physiological phenomenon due to starvation or ketogenic diet ( KD ), drastic restricted carbohydrate dietary regimen that induces lipid metabolism ketone body synthesis. Two patients whose migraines disappeared only during, not outside, cycles of very‐low‐calorie performed reduce their weight were recently observed. To confirm our observation, in dietitian clinical setting two parallel groups migraineurs, one receiving 1‐month prescription followed by...
Despite the increasing body of evidence supporting hypothesis schizophrenia as a disconnection syndrome, studies resting-state EEG Source Functional Connectivity (EEG-SFC) in people affected by are sparse. The aim present study was to investigate EEG-SFC 77 stable, medicated patients with (SCZ) compared 78 healthy volunteers (HV). In order effect illness duration, SCZ were divided those short duration disease (SDD; n = 25) and long (LDD; 52). Resting-state recordings eyes closed condition...
We used MRI to search for changes in thalamo-cortical networks and thalamic microstructure during spontaneous migraine attacks by studying at the same time structure with diffusion tensor imaging resting state function interconnected brain independent component analysis.Thirteen patients untreated without aura (MI) underwent 3T scans an attack were compared a group of 19 healthy controls (HC). collected data 2 selected identified using (IC) analysis. Fractional anisotropy (FA) values...
Background Previous functional MRI studies have revealed that ongoing clinical pain in different chronic syndromes is directly correlated to the connectivity strength of resting default mode network (DMN) with insula. Here, we investigated seed-based state DMN-insula during acute migraine headaches. Methods Thirteen without aura patients (MI) underwent 3 T scans initial six hours a spontaneous attack, and were compared group 19 healthy volunteers (HV). We evaluated headache intensity visual...
To date, few MRI studies have been performed in patients affected by chronic migraine (CM), especially those without medication overuse. Here, we magnetic resonance imaging (MRI) voxel-based morphometry (VBM) analyses to investigate the gray matter (GM) volume of whole brain CM. Our aim was whether fluctuations GM volumes were related clinical features Twenty untreated with CM a past medical history overuse underwent 3-Tesla scans and compared group 20 healthy controls (HCs). We used SPM12...
Here we aimed at determining the therapeutic effect of a very low-calorie diet in overweight episodic migraine patients during weight-loss intervention which subjects alternated randomly between ketogenic (VLCKD) and non-ketogenic (VLCnKD) each for one month. In nutritional program, 35 obese sufferers were allocated blindly to 1-month successive VLCKD or VLCnKD random order (VLCKD-VLCnKD VLCnKD-VLCD). The primary outcome measure was reduction days month compared pre-diet baseline. Secondary...
The aim of this study was to compare the effectiveness strong advice withdraw overused medication with two structured pharmacological detoxification strategies in a cohort patients diagnosed probable migraine overuse headache (MOH) plus and presenting low medical needs. One hundred twenty participated study. Exclusion criteria included: previous treatments, coexistent or psychiatric illnesses agents containing opioids, benzodiazepines barbiturates. Group A received only intensive medication....
Medication-overuse headache (MOH) is a frequent, disabling disorder. Despite controversial pathophysiology convincing evidence attributes pivotal role to central sensitization. Most patients with MOH initially have episodic migraine without aura (MOA) characterized interictally by an absent amplitude decrease in cortical evoked potentials repetitive stimuli (habituation deficit), despite normal initial (lack of sensitization). Whether sensitization alters this electrophysiological profile...
Background and purpose The thalamus seems to be profoundly involved in the cyclical recurrence of migraine clinical neurophysiological features. Here possible structural changes migraineurs were searched for by means diffusion tensor ( DT ) magnetic resonance imaging MRI ). This technique provides quantitative data on water molecule motion as a marker tissue microstructure. Methods Twenty‐four untreated without aura MO patients underwent ‐ scans (3‐ T S iemens G yroscan) during n = 10)...
The interictal deficit of habituation to repetitive visual stimuli in migraine patients could be due deficient intracortical inhibition and/or low cortical pre-activation levels. Which these abnormalities contributes more the cannot determined with common methods used record transient responses. We investigated lateral cortex during cycle and healthy subjects by using differential temporal modulations radial windmill-dartboard (WD) or partial-windmill (PW) patterns. Transient (TR-VEP)...
Resting state magnetic resonance imaging allows studying functionally interconnected brain networks. Here we were aimed to verify functional connectivity between networks at rest and its relationship with thalamic microstructure in migraine without aura (MO) patients attacks. Eighteen untreated MO underwent 3 T MRI scans compared a group of 19 healthy volunteers (HV). We used collect resting data among two selected networks, identified using independent component (IC) analysis. Fractional...
Neurophysiological investigations have demonstrated that there are unique fluctuations in the migraine brain functional activity between ictal and interictal periods. Here we investigated possibility over time also whole morphometry of patients affected by episodic without aura (MO).Twenty-four with untreated MO underwent 3T MRI scans during (n = 10) or attacks 14) were compared to a group 15 healthy volunteers (HVs). We then performed voxel-based-morphometry (VBM) analysis structural...
Episodic migraine is characterized by decreased high-frequency somatosensory oscillations (HFOs), reflecting thalamo-cortical activity, and deficient habituation of low-frequency (LF-) evoked potentials (SSEPs) to repetitive sensory stimulation between attacks. Here, we study conventional LF-SSEPs HFOs in episodic migraineurs who developed chronic (CM).Thirty-four (15 interictally [MOii], 19 ictally [MOi]) CM patients underwent right median nerve SSEPs. The patient groups were compared a...
Here, we aim to identify cortical electrofunctional correlates of responsiveness short-lasting preventiveintervention with ketogenic diet (KD) in migraine. Eighteen interictal migraineurs underwent visual (VEPs) and median nerve somatosensory (SSEPs) evokedpotentials before after 1 month KD during ketogenesis. We measured VEPs N1-P1 SSEPs N20-P25 amplitudes respectively six two sequential blocks 100 sweeps as well habituation theslope the linear regression between block 6 for or 2 SSEPs....
We investigated resting-state (RS)-fMRI using independent component analysis (ICA) to determine the functional connectivity (FC) between networks in chronic migraine (CM) patients and their correlation with clinical features.Twenty CM without preventive therapy or acute medication overuse underwent 3T MRI scans were compared a group of 20 healthy controls (HC). used collect RS data 3 selected networks, identified ICA: default mode network (DMN), executive control (ECN), dorsal attention...
The ketogenic diet (KD) is gaining attention as a preventive treatment for migraine, which sustained by many pre-clinical and clinical data. KD also used weight loss, there relation between migraine excess, but it speculated that efficacy on may go beyond this effect. We conducted retrospective observational study 23 patients who received were evaluated at the baseline then after 3 months both from neurological nutritional point of view, including body mass composition analysis. observed...