A5076887783- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Functional Brain Connectivity Studies
- Vestibular and auditory disorders
- Olfactory and Sensory Function Studies
- Ophthalmology and Eye Disorders
- Transcranial Magnetic Stimulation Studies
- Sympathectomy and Hyperhidrosis Treatments
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Syncope and Autonomic Disorders
- Multisensory perception and integration
- Glaucoma and retinal disorders
- Pain Mechanisms and Treatments
- Nutritional Studies and Diet
- Botulinum Toxin and Related Neurological Disorders
- Optical Coherence Tomography Applications
- Theology and Canon Law Studies
- Vagus Nerve Stimulation Research
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Hallucinations in medical conditions
- Classical Studies and Legal History
- Diet and metabolism studies
- Nasolacrimal Duct Obstruction Treatments
Sapienza University of Rome
2020-2025
Weatherford College
2020
Centre Hospitalier Universitaire de Liège
2020
Università Cattolica del Sacro Cuore
2020
University of Ferrara
2003
(1) Background: OnabotulinumtoxinA (BoNT-A) is a commonly used prophylactic treatment for chronic migraine (CM). Although randomized placebo studies have shown its clinical efficacy, the mechanisms by which it exerts therapeutic effect are still incompletely understood and debated. (2) Methods: We studied in 15 CM patients cephalic extracephalic nociceptive lemniscal sensory systems using electrophysiological techniques before 1 3 months after one session of pericranial BoNT-A injections...
The migrainous aura has different clinical phenotypes. While the various differences are well-described, little is known about their neurophysiological underpinnings. To elucidate latter, we compared white matter fiber bundles and gray cortical thickness between healthy controls (HC), patients with pure visual auras (MA) complex neurological (MA+).3T MRI data were collected attacks from 20 MA 15 MA+, those 19 HCs. We analyzed using tract-based spatial statistics (TBSS) of diffusion tensor...
Rimegepant, a novel oral calcitonin gene-related peptide receptor antagonist, has been recently approved for the acute migraine treatment. While its efficacy was confirmed in randomized clinical trials, no data is available regarding real-life effectiveness and tolerability. GAINER, prospective, multicentric study, aimed to evaluate rimegepant tolerability real-world setting. Our study involved 16 headache centers across Italy. The main outcomes were: i) 2 h pain freedom, ii) occurrence of...
Finding a biomarker to diagnose migraine remains significant challenge in the headache field. Migraine patients exhibit dynamic and recurrent alterations brainstem-thalamo-cortical loop, including reduced thalamocortical activity abnormal habituation during interictal phase. Although these insights into pathophysiology have been valuable, they are not currently used clinical practice. This study aims evaluate potential of Artificial Neural Networks (ANNs) distinguishing from healthy...
Background: Evidence from animal studies suggests that monoclonal antibodies targeting the calcitonin gene-related peptide (anti-CGRP mAbs) may only minimally penetrate blood-brain barrier due to their high molecular weight. However, neuroimaging and electrophysiological revealed indirect neuromodulatory effects originating peripherally moving toward central nervous system. This pilot study aimed investigate cortical inhibitory activity by recording silent period (SP) triggered transcranial...
<title>Abstract</title> Background The hypothalamus is thought to play a crucial role in the recurrence of migraine attacks, exhibiting activity prior onset attack. Nonetheless, our comprehension roles its subunits, especially during interictal phase, remains limited. This study investigated hypothalamic volumetric differences between individuals with episodic and healthy controls, scans conducted free from effects preventative medications. Methods We analyzed volumes 30 patients without...
It is unclear whether the electrophysiological effects of erenumab, a monoclonal antibody against calcitonin gene-related peptide receptor, occur only at periphery trigeminal system or centrally and cortical level.We prospectively enrolled 20 patients with migraine who had failed least two preventative treatments. We measured nociceptive blink reflex non-noxious somatosensory evoked potentials in all participants. The area under curve habituation second polysynaptic component (R2) as well...
It is unclear whether cortical hyperexcitability in chronic migraine with medication overuse headache (CM-MOH) due to increased thalamocortical drive or aberrant inhibitory mechanisms.Somatosensory evoked potentials (SSEP) were performed by electrical stimulation of the median nerve (M), ulnar (U) and simultaneous both nerves (MU) 27 patients CM-MOH and, for comparison, 23 healthy volunteers (HVs) a comparable age distribution. We calculated degree lateral inhibition using formula: 100 -...
Short-latency afferent inhibition (SAI) consists of motor cortex induced by sensory afferents and depends on the excitatory effect cholinergic thalamocortical projections inhibitory GABAergic cortical networks. Given electrophysiological evidence for thalamo-cortical dysrhythmia in migraine, we studied SAI migraineurs during between attacks searched correlations with somatosensory habituation, activation, clinical features.SAI was obtained conditioning transcranial magnetic...
Background: Migraine is a brain disorder characterized by recurring headache attacks, and emotional comorbidities, such as anxiety depression, may influence the repetition of these attacks. The lack sensory habituation common neurophysiological abnormality in migraine, research suggests that it under serotonin other monoamines are also involved mood disorders. This study aimed to investigate symptoms on cortical information processing patients with migraine aura correlating activity...
Merging of sensory information is a crucial process for adapting the behaviour to environment in all species. It not known if this multisensory integration might be dysfunctioning interictally migraine without aura, where stimuli various modalities are processed abnormally when delivered separately. To investigate question, we compared effects concomitant visual stimulation on conventional low-frequency somatosensory evoked potentials and embedded high-frequency oscillations between patients...
The case of a 72-year-old woman with diffuse large B-cell lymphoma the lacrimal sac is reported. patient was evaluated for first time in our department tearing right eye. One month later, slightly aching mass appeared over sac. An acute infectious etiology suspected and antibiotic therapy given. When she finally presented rapidly growing lesion, underwent echography computed tomography followed by incisional biopsy. Results histopathologic immunohistochemical evaluation showed primary,...
Background/Objectives: Habituation and sensitization are opposite phenomena that play a role in the pathophysiology of episodic migraine its progression to chronic (CM). There have been just few studies investigated these patients with medication overuse headache (MOH) comparison those (CM) healthy controls (HCs), findings inconsistent. Methods: We measured examined visual evoked potentials (VEPs) 81 MOH 24 CM, as well HCs. The VEPs were used assess by analyzing amplitude first block (100...
Since the habituation deficit of evoked potentials could be related to abnormal thalamocortical drive, we searched for a modulatory effect ketogenic diet (KD) on somatosensory-evoked thalamo-cortical activity. KD is effective in preventing migraine. Previous studies showed that normalises somatosensory and visual cortical responses parallel with decrease migraine attack frequency.
Background It is still debatable whether the mechanisms underlying photophobia are related to altered visual cortex excitability or specific abnormalities of colour-related focal macular retino-thalamic information processing. Methods This cross-sectional study examined Ganzfeld blue-red (B-R) and blue-yellow (B-Y) cone flash ERG (ffERG) focal-flash evoked potentials (ffVEPs) simultaneously in a group migraine patients with (n = 18) without 19) aura during interictal phase, comparison...
: Habituation and sensitization are opposite phenomena that play a role in the pathophysiology of episodic migraine its progression to chronic (CM). There have been just few studies investigated these patients with medication overuse headache (MOH) comparison those (CM) healthy controls (HCs), findings inconsistent.