A5100661890- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Menstrual Health and Disorders
- Blind Source Separation Techniques
- Stress Responses and Cortisol
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Music Perception
- Schizophrenia research and treatment
- Biosensors and Analytical Detection
- Family Caregiving in Mental Illness
- Mental Health Treatment and Access
- Advanced Neuroimaging Techniques and Applications
- Treatment of Major Depression
- Intracerebral and Subarachnoid Hemorrhage Research
- Neural and Behavioral Psychology Studies
- Heart Rate Variability and Autonomic Control
- Medical Image Segmentation Techniques
- Transcranial Magnetic Stimulation Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Music Therapy and Health
- Bipolar Disorder and Treatment
- Pain Mechanisms and Treatments
- Visual perception and processing mechanisms
- Advanced MRI Techniques and Applications
National Yang Ming Chiao Tung University
2016-2025
Bali Psychiatric Center
2024-2025
Ministry of Health and Welfare
2024-2025
Dalian Medical University
2018-2024
Chongqing Medical University
2018-2024
Second Affiliated Hospital of Chongqing Medical University
2018-2024
Taipei Veterans General Hospital
2015-2024
Jiaxing University
2020-2024
GTx (United States)
2024
Nanjing University of Chinese Medicine
2024
Theta-burst transcranial magnetic stimulation could modulate cortical excitability and has the potential to treat refractory depression. However, there been a lack of large randomized studies antidepressant efficacy different forms theta-burst stimulation, such as intermittent continuous stimulation. A sham-controlled study was conducted investigate compare among left-prefrontal right-prefrontal combination them in patients showing levels refractoriness. group 60 treatment-refractory with...
Primary dysmenorrhea (PDM) is the most prevalent gynecological disorder for women in reproductive age. PDM patients suffer from lower abdominal pain that starts with onset of menstrual flow. Prolonged nociceptive input to central nervous system can induce functional and structural alterations throughout system. In PDM, a chronic viscero-nociceptive drive cyclic nature, indications sensitization altered brain metabolism suggest substantial reorganization. Previously, we hypothesized...
Family caregivers play crucial roles in taking care of people experiencing schizophrenia the community. The burdens on and needs these patients should be emphasized. This study aimed to explore perspective family communities Beijing terms acquisition further need for support order provide guidance health providers regarding how target therapeutic interventions families individuals recommendations policy makers tailor countermeasures services. A total 20 were enrolled our study. face-to-face...
In Brief Menstrual pain is the most prevalent gynecological complaint, and usually without organic cause (termed primary dysmenorrhea, PDM). The high comorbidity in later life of PDM with many functional disorders (associated central dysfunction inhibition, eg, fibromyalgia) suggests possible maladaptive functionality modulatory systems already occurred young women, making them vulnerable to disorders. Periaqueductal gray (PAG) matter functions as a critical hub neuraxis systems; therefore,...
Abstract Background The benefits of low-dose ketamine for patients with treatment-resistant depression (TRD) and prominent suicidal ideation require further investigation. effects treatment refractoriness, the duration current depressive episode, number prior antidepressant failures on efficacy also clarification. Methods We recruited 84 outpatients TRD ideation—defined as a score ≥4 item 10 Montgomery–Åsberg Depression Rating Scale (MADRS)—and randomized them into 2 groups to receive 0.5...
A novel aptamer-based label-free electrochemical impedance spectroscopy biosensor for 17β-estradiol has been fabricated. The aptamers were firstly immobilized on the gold electrode through Au-S interaction; aptamer probe was then bound with addition of to form estradiol/aptamer complex surface. This leads a significantly larger interfacial electron transfer resistance than that without 17β-estradiol. change in had linear relationship concentration range 1.0 × 10(-8) 10(-11) mol L(-1),...
Prefrontal left-right functional imbalance and disrupted prefronto-thalamic circuitry are plausible mechanisms for treatment-resistant depression (TRD). Add-on repetitive transcranial magnetic stimulation (rTMS), effective in treating antidepressant-refractory TRD, was administered to verify the core underlying refractoriness antidepressants. Thirty TRD patients received a 2-week course of 10-Hz rTMS left dorsolateral prefrontal cortex (DLPFC). Depression scores were evaluated at baseline...
This study investigates the cortical abnormalities of early emotion perception in patients with major depressive disorder (MDD) and bipolar (BD) using gamma oscillations. Twenty-three MDD patients, twenty-five BD twenty-four normal controls were enrolled their event-related magnetoencephalographic responses recorded during implicit emotional tasks. Our results demonstrated abnormal activity within 100 ms emotion-related regions (amygdala, orbitofrontal (OFC) cortex, anterior insula (AI),...
Abstract Primary dysmenorrhea (PDM) is the most prevalent gynecological problem. Many key brain systems are engaged in pain processing. In light of dynamic communication within and between (or networks) shaping experience behavior, intra-regional functional connectivity (FC) hub regions may be altered interactions terms inter-regional FCs among networks reorganized to cope with repeated stress menstrual PDM. Forty-six otherwise healthy PDM subjects 49 age-matched, female control were...
Nicotinamide N-methyltransferase (NNMT) plays multiple roles in improving the aggressiveness of colorectal cancer (CRC) and enhancing resistance to 5-Fluorouracil (5-FU), making it an attractive therapeutic target. Curcumin (Cur) is a promising natural compound, exhibiting antitumor effects potentiating effect 5-FU. The aim present study explore Cur on attenuating NNMT-induced 5-FU CRC. A panel CRC cell lines with different NNMT expressions are used characterize Cur. Herein, observed that...
Closed-loop neuromodulation is a promising personalized treatment for various neuropsychiatric disorders, delivering precise stimuli based on real-time brain signals. However, its clinical potential currently limited by technical challenges inherent in nature. This article addresses the primary EEG-Phase-Synchronized Transcranial Magnetic Stimulation (TMS), including poor stimulation accuracy and inefficient biomarker detection (correlated with deadlock). These arise from vulnerability of...
Abstract Visceral hypersensitivity in gastric fundus is a possible pathogenesis for functional dyspepsia. The cortical representation of still unclear. Growing evidence shows that the insula, but not primary or secondary somatosensory region (SI SII), may be target visceral pain. Animal studies have also demonstrated amygdala plays an important role processing We used fMRI to study central projection stomach pain from balloon distension. tested hypothesis there will neither S1 nor S2...
Female fertility declines with age, and this natural variation culminates in reproductive senescence. Human follicular fluids are rich low-molecular weight metabolites which responsible for the maturation of oocytes. The metabolomic approaches powerful tools to study biochemical markers oocyte quality fluids. It is necessary identify quantify reliable reflecting developmental potential. goal conduct a analysis women different ages profile relationship assisted technology (ART) treatment. A...
Abstract Introduction: Severe primary dysmenorrhea (PDM) is a distressing pain affecting 10% to 25% of menstruating women. Little known about the analgesic efficacy and neural mechanisms transcranial direct current stimulation (tDCS) at motor area (M1) for menstrual control. Objectives: We examined anodal tDCS over left M1 patients with severe PDM studied functional connectivity (FC) changes between periaqueductal gray matter (PAG) medial (MMA) elucidate possible central mechanisms. Methods:...