A5000579005- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Tryptophan and brain disorders
- Transcranial Magnetic Stimulation Studies
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Schizophrenia research and treatment
- Attention Deficit Hyperactivity Disorder
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Stress Responses and Cortisol
- Pain Management and Treatment
- Neural and Behavioral Psychology Studies
- Migraine and Headache Studies
- Autism Spectrum Disorder Research
- Asthma and respiratory diseases
- Electroconvulsive Therapy Studies
- Adolescent and Pediatric Healthcare
- Dermatology and Skin Diseases
- Advanced MRI Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Obsessive-Compulsive Spectrum Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Suicide and Self-Harm Studies
- Parkinson's Disease Mechanisms and Treatments
National Yang Ming University Hospital
2013-2025
Taipei Veterans General Hospital
2016-2025
National Yang Ming Chiao Tung University
2016-2025
National Central University
2016-2024
National Defense Medical Center
2022-2023
Tri-Service General Hospital
2022
China Medical University Hospital
2022
China Medical University
2022
Cheng Hsin General Hospital
2019-2022
Faculty (United Kingdom)
2020
Theta-burst transcranial magnetic stimulation could modulate cortical excitability and has the potential to treat refractory depression. However, there been a lack of large randomized studies antidepressant efficacy different forms theta-burst stimulation, such as intermittent continuous stimulation. A sham-controlled study was conducted investigate compare among left-prefrontal right-prefrontal combination them in patients showing levels refractoriness. group 60 treatment-refractory with...
To evaluate long-term safety and efficacy of esketamine nasal spray plus a new oral antidepressant (OAD) in patients with treatment-resistant depression (TRD).This phase 3, open-label, multicenter, (up to 1 year) study was conducted between October 2015 2017. Patients (≥ 18 years) TRD (DSM-5 diagnosis major depressive disorder nonresponse ≥ 2 OAD treatments) were enrolled directly or transferred from short-term (patients aged 65 years). Esketamine (28-mg, 56-mg, 84-mg) administered twice...
The endogenous cannabinoid anandamide is removed from the synaptic space by a high-affinity transport system present in neurons and astrocytes, which inhibited N-(4-hydroxyphenyl)-arachidonamide (AM404). After internalization, hydrolyzed fatty-acid amide hydrolase (FAAH), an intracellular membrane-bound enzyme that also cleaves AM404. Based on kinetic evidence, it has recently been suggested internalization may be mediated passive diffusion driven FAAH activity. To test this possibility,...
People with major depressive disorder who fail to respond adequate trials of antidepressant treatment may harbour hidden bipolar disorder.We aimed compare the rates a change in diagnosis among people stratified responses antidepressants during an 8-year follow-up period.Information on individuals identified 2000 (cohort 2000, n = 1485) and 2003 2003, 2459) were collected from nationally representative cohort 1,000,000 health service users Taiwan. Participants responding well compared those...
Studies have suggested the association between autism spectrum disorder (ASD) and type 2 diabetes mellitus (DM)-related risk factors, such as obesity dyslipidemia. However, ASD DM remains unknown.We used Taiwan National Health Insurance Research Database for enrolling 6,122 adolescents young adults with 24,488 age- sex-matched control subjects 2002 2009 monitored them until end of 2011. Participants who developed during follow-up period were identified.Adolescents (hazard ratio [HR] 2.71...
Abstract Background Low‐dose ketamine has been found to have robust and rapid antidepressant effects. A hypoactive prefrontal cortex (PFC) a hyperactive amygdala suggested be associated with treatment‐resistant depression (TRD). However, it is unclear whether the mechanisms of on TRD involve changes in glutamatergic neurotransmission PFC amygdala. Methods group 48 patients were recruited equally randomized into three groups (A: 0.5 kg/mg‐ketamine; B: 0.2 C: normal saline [NS]). Standardized...
Objective Research evidence has shown that bipolar disorder (BD) and unipolar depression (UD) are both related to inflammatory dysregulation, but few studies have compared the levels of cytokines between these two disorders. Methods Study subjects were age- gender-matched outpatients with BD or UD normal controls (NC). Severities mania symptoms assessed Montgomery–Åsberg Depression Rating Scale (MADRS) Young Mania (YMRS). Pro-inflammatory cytokines, including soluble interleukin-6 receptor...
Background Previous evidence has shown positive associations between post-traumatic stress disorder (PTSD) and hypertension, dyslipidaemia diabetes mellitus, which are all risk factors for stroke, but the role of PTSD in subsequent development stroke is still unknown. Aims To investigate temporal association stroke. Method Identified from Taiwan National Health Insurance Research Database, 5217 individuals aged 18 years, with no history 20 868 age- gender-matched controls were enrolled 2002...
Previous studies reported a high prevalence of depression among patients with autism spectrum disorder (ASD) and suggested relationship between ASD suicidality. However, whether independently increases the risk attempted suicide regardless has not been determined.Using Taiwan National Health Insurance Research Database, 5,618 adolescents aged 12-17 years young adults 18-29 (ICD-9-CM code: 299) 22,472 age- sex-matched controls were enrolled 2001 2009 followed to end 2011. Any attempt was...