A5046145690- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Hepatitis C virus research
- Pancreatic and Hepatic Oncology Research
- COVID-19 Clinical Research Studies
- Diet, Metabolism, and Disease
- Computational Drug Discovery Methods
- Nutrition and Health in Aging
- Diet and metabolism studies
- Diabetes Treatment and Management
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Complement system in diseases
- Viral Infections and Vectors
- Chronic Disease Management Strategies
- Endoplasmic Reticulum Stress and Disease
- Genetic Associations and Epidemiology
- Ferroptosis and cancer prognosis
- Health, Environment, Cognitive Aging
- Cardiovascular Disease and Adiposity
- Autophagy in Disease and Therapy
- Sepsis Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
Shanghai Clinical Research Center
2022-2025
Shandong Provincial Hospital
2022-2025
Shandong First Medical University
2022-2025
Shandong Academy of Chinese Medicine
2022-2025
Shandong Center for Disease Control and Prevention
2022-2025
Shandong University
2022-2025
Ministry of Education of the People's Republic of China
2024
First Affiliated Hospital of Xi'an Jiaotong University
2018-2023
Cleveland Clinic
2020-2022
Jinan Central Hospital
2022
Objective Systemic immune-inflammation index (SII), a novel inflammatory indicator based on platelets, neutrophils and lymphocytes, has been shown to be associated with prognostic value in several solid tumors. However, its nonalcoholic fatty liver disease (NAFLD) not reported yet. Therefore, the present study aimed investigate of SII individuals NAFLD.Methods Data was collected from 2005 2014 National Health Nutrition Examination Survey (NHANES, https://www.cdc.gov/nchs/nhanes/index.htm),...
The changes of inflammation and metabolism are two features in nonalcoholic steatohepatitis (NASH). However, how they interact to regulate NASH progression remains largely unknown. Our works have demonstrated the importance solute carrier family 7 member 11 (SLC7A11) metabolism. Nevertheless, whether SLC7A11 regulates through mediating is unclear. In this study, we found that expression was increased liver samples from patients with NASH. Upregulated level also detected murine models....
Advances in immuno-oncology (IO) are making immunotherapy a powerful tool for cancer treatment. With the discovery of an increasing number IO targets, many herbs or ingredients from traditional Chinese medicine (TCM) have shown immunomodulatory function and antitumor effects via targeting immune system. However, knowledge underlying mechanisms is limited due to complexity TCM, which has multiple acting on targets. To address this issue, we present TCMIO, comprehensive database Traditional...
Upregulated T-cell immunoglobulin and mucin domain containing molecule-3 (Tim-3) in hepatitis B virus (HBV)-specific CD8+ T-cells contributes to exhaustion during chronic HBV infection. The membrane-bound Tim-3 can be cleaved from the cell surface by sheddase, yielding soluble (sTim-3). This study investigated serum sTim-3 levels patients with infection of various liver diseases.Serum were quantitatively determined 288 diseases. analyzed relation diseases including HBV-related hepatocellular...
Hepatocellular carcinoma (HCC) is the most common liver cancer and mechanisms of hepatocarcinogenesis remain elusive.This study aims to mine hub genes associated with HCC using multiple databases.Data sets GSE45267, GSE60502, GSE74656 were downloaded from GEO database. Differentially expressed (DEGs) between control in each set identified by limma software. The GO term KEGG pathway enrichment DEGs aggregated datasets (aggregated DEGs) analyzed DAVID KOBAS 3.0 databases. Protein-protein...
Hepatocellular death contributes to progression of alcohol–associated (ALD-associated) and non–alcohol-associated (NAFL/NASH) liver diseases. However, receptor-interaction protein kinase 3 (RIP3), an intermediate in necroptotic cell death, injury murine models ALD but not NAFL/NASH. We show here that a differential role for mixed-lineage domain–like (MLKL), the downstream effector RIP3, versus NAFL/NASH RIP1-RIP3-MLKL can be used as biomarkers distinguish alcohol-associated hepatitis (AH)...
Mixed lineage kinase domain-like pseudokinase (MLKL), a key terminal effector of necroptosis, also plays role in intracellular vesicle trafficking that is critical for regulating liver inflammation and injury alcohol-associated disease (ALD). Although receptor interacting protein 3 (Rip3)-/- mice are completely protected from ethanol-induced injury, Mlkl-/- only partially protected. Therefore, we hypothesized cell-specific functions MLKL may contribute to injury.
Objective Some studies have demonstrated a bidirectional association between obesity and depression, whereas others not. This discordance might be due to the metabolic health status. We aimed determine whether relationship depression is dependent on Methods In total, 9,022,089 participants were enrolled classified as one of four phenotypes: metabolically healthy nonobesity (MHNO), unhealthy (MUNO), (MHO), (MUO). then divided population into eight phenotypes based number risk factors....
Introduction This study aimed to examine the risk of common diseases among people with pre-diabetes and explored relationship between multimorbidity (in this case, two or more comorbid diseases). Methods An observational multicohort using data from UK Biobank database National Inpatient Sample (NIS) (2016–2018) was conducted. We analysed 461 535 participants 17 548 442 patients aged 18 years older both databases, whom 14.0% 0.7% were diagnosed pre-diabetes, respectively. A total 76 various...
Abstract Aims The growing epidemic of overweight and obesity elevates disease risks, with metabolic disorders inflammation critically involved in the pathogenic mechanisms. This study refines subtyping using inflammatory markers to enhance risk assessment personalized prevention. Materials Methods Based on UK Biobank, this retrospective included participants classified as or obese (BMI ≥25 kg/m 2 ). K‐means clustering was performed biomarkers. Multivariate Cox regression analysis assessed...
Over the past several decades, natural products with poly-pharmacological profiles have demonstrated promise as novel therapeutics for various complex diseases, including cancer. Berberine (PubChem CID: 2353), a soliloquies quaternary alkaloid, has been validated to exert powerful effects in many cancers. However, underlying molecular mechanism is not yet fully elucidated. In this study, we summarized of berberine against multiple cancers based on current available literatures. Furthermore,...
Abstract Advances in immunotherapy have revolutionized treatments many types of cancer. Traditional Chinese Medicine (TCM), which has a long history clinical adjuvant application against cancer, is emerging as an important medical resource for developing innovative cancer treatments, including immunotherapy. In this study, we developed quantitative and systems pharmacology-based framework to identify TCM-derived natural products Specifically, integrated 381 immune response-related genes...