A5104258776- Aquaculture Nutrition and Growth
- Genetic diversity and population structure
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Pancreatic and Hepatic Oncology Research
- Bacteriophages and microbial interactions
- Diabetes Treatment and Management
- Genomics and Phylogenetic Studies
- Medical Research and Treatments
- Advanced Sensor and Control Systems
- Glycosylation and Glycoproteins Research
- Simulation and Modeling Applications
- Natural Antidiabetic Agents Studies
- Chronic Disease Management Strategies
- Hepatitis C virus research
- Protein Hydrolysis and Bioactive Peptides
- Invertebrate Immune Response Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- HIV/AIDS drug development and treatment
- Bioenergy crop production and management
- Cannabis and Cannabinoid Research
- Congenital gastrointestinal and neural anomalies
- Thyroid and Parathyroid Surgery
- Diabetes Management and Education
- Nuts composition and effects
Shandong Provincial Hospital
2025
Shandong University
2025
Shanghai Clinical Research Center
2025
Shandong Academy of Chinese Medicine
2025
Shandong First Medical University
2022-2025
Binzhou University
2024
Hebei Science and Technology Department
2022-2024
Binzhou Medical University
2024
Yunnan Agricultural University
2023-2024
Shanghai Medical College of Fudan University
2024
We investigated lenvatinib plus programmed cell death-1 (PD-1) inhibitors as a first-line treatment for initially unresectable biliary tract cancer (BTC).In this Phase II study, adults with BTC received (body weight ≥60 kg, 12 mg; <60 8 mg) daily and PD-1 (pembrolizumab/tislelizumab/sintilimab/camrelizumab 200 mg or toripalimab 240 every 3 weeks. Primary endpoints were objective response rate (ORR) safety. Secondary included surgical conversion rate, disease control (DCR), event-free...
Walnut dreg protein hydrolysates (WDPHs) exhibit a variety of biological activities, however, the cyclooxygenase-2 (COX-2) inhibitory peptide WDPHs remain unclear. The aim this study was to rapidly screen for such peptides in through combination <i>in silico</i> and vitro</i> analysis. In total, 1262 sequences were observed by nano liquid chromatography/tandem mass spectrometry (nano LC-MS/MS) 4 novel COX-2 (AGFP, FPGA, LFPD, VGFP) identif ied. Enzyme kinetic data indicated that AGFP, LFPD...
Introduction This study aimed to examine the risk of common diseases among people with pre-diabetes and explored relationship between multimorbidity (in this case, two or more comorbid diseases). Methods An observational multicohort using data from UK Biobank database National Inpatient Sample (NIS) (2016–2018) was conducted. We analysed 461 535 participants 17 548 442 patients aged 18 years older both databases, whom 14.0% 0.7% were diagnosed pre-diabetes, respectively. A total 76 various...
ABSTRACT GS-9669 is a highly optimized thumb site II nonnucleoside inhibitor of the hepatitis C virus (HCV) RNA polymerase, with binding affinity 1.35 nM for genotype (GT) 1b protein. It selective HCV replication, mean 50% effective concentration (EC 50 ) ≤11 in 1 and 5 replicon assays, but lacks useful activity against genotypes 2 to 4. The M423T mutation readily generated clinically upon monotherapy inhibitors filibuvir lomibuvir, it notable that exhibited only 3-fold loss potency this...
Abstract The swimming crab, Portunus trituberculatus , is one of the main aquaculture species in Chinese coastal regions due to its palatability and high economic value. To obtain a better understanding genetic diversity P. Bohai Sea, present study used 40 SSR loci investigate population structure 420 individuals collected from seven populations Sea. Genetic parameters revealed low level cultured ( SI = 1.374, He 0.687, PIC 0.643) comparison with wild ≥ 1.399, 0.692, 0.651). differentiation...
GLP-1 receptor agonists (GLP-1 RA) have been proven to treat several metabolic diseases; however, the effects of RA on polycystic ovary syndrome (PCOS) remain unclear. Here, we aimed investigate whether semaglutide, a novel RA, could alleviate ovarian inflammation in PCOS mice.
P. trituberculatus is an economically important mariculture species in China. Evaluating its genetic diversity and population structure can contribute to the exploration of germplasm resources promote sustainable aquaculture production. In this study, a total 246,243 SSRs were generated by transcriptome sequencing trituberculatus. Among examined 254,746 unigenes, 66,331 had more than one SSR. different SSR motif types, dinucleotide repeats (110,758, 44.98%) most abundant. 173 base repeats,...
Our previous study proved that the peptide MOp2 from Moringa oleifera seeds exhibited membrane-damaging effects on Staphylococcus aureus. In this study, TMT-based proteomics technology was mainly used to investigate antimicrobial mechanism of against S. A total 541 differentially expressed proteins (DEPs) were identified in aureus treated with MOp2, among which 256 and 285 DEPs upregulated downregulated, respectively. They involved inositol phosphate metabolism, infection, citrate cycle (TCA...
BACKGROUNDAs Omicron is prompted to replicate in the upper airway, neutralizing antibodies (NAbs) delivered through inhalation might inhibit early-stage infection respiratory tract. Thus, elucidating prophylactic efficacy of NAbs via nasal spray addresses an important clinical need.METHODSThe applicable potential a cocktail containing 2 was characterized by testing its potency, synergetic mechanism, emergency protective and therapeutic hamster model, pharmacokinetics/pharmacodynamic (PK/PD)...
Background Recently, in many Asian centers, laparoscopic anatomical liver resection (LALR) using the indocyanine green (ICG) fluorescence imaging technique has been increasingly applied resecting hepatocellular carcinoma, even colorectal metastases. However, LALR techniques have not fully standardized, especially right superior segments. Due to position, prevailing positive staining a PTCD (percutaneous transhepatic cholangial drainage) needle was negative segments hepatectomy, while it...
Rationale: Primary hyperparathyroidism (PHPT) during pregnancy is rare. Nevertheless, hypercalcemia secondary to gestational PHPT may be masked by physiological changes in calcium homeostasis pregnancy. Gestational constitutes a serious danger mother and fetus. Surgery the only curative treatment when conservative could not control condition. Due lack of guidelines concerning pregnancy, optimal anesthetic management needs individualized. Patient concerns: We report case with successful...
Abstract Background: Early detection of primary liver cancer (PLC) in individuals with cirrhosis (LC) or chronic hepatitis virus infection (CHVI) improves survival. Timely, effective, and affordable tools high sensitivity are urgently needed clinical practice. Methods: Tissue and/or plasma samples from 159 healthy 89 PLC, LC, CHVI patients were sequenced by a targeted methylation panel (~70,000 CpGs) to screen candidate methylated DNA markers (MDMs). In phase I, the performance each selected...
Abstract Neutralizing monoclonal antibodies (NAbs) with prophylactic and therapeutic efficacy have demonstrated fundamental importance in the control of SARS-CoV-2 transmission. However, their wide application has been largely limited by high cost inconvenience administration. Here, we developed an intranasal spray containing two synergetic human NAbs that could broadly neutralize emerging Omicron variants vitro. A unique neutralizing mechanism was identified bound to exclusive epitopes on...
The swimming crab (Portunus trituberculatus) is a valuable crustacean species extensively cultivated in China, owing to its fast development, palatability, and rich nutrition. However, the genetic factors regulating growth remain elusive, impeding progress of breeding initiatives for this economically important species. In study, we combined bulk segregation analysis sequencing (BSA-seq) transcriptome (RNA-seq) identify potential candidate genes related body weight P. trituberculatus using...
β-Conglycinin is one of the major allergens existed in soybean. N-Glycans attached to β-conglycinin influenced immunoreactivity and antigen presenting efficiency β-conglycinin. In this study, we described a new method used release collect N-glycans from β-conglycinin, linear epitopes were identified. Glycopeptides hydrolyzed purified by cotton hydrophilic chromatography. Trifluoromethylsulfonic acid was then glycans glycopeptides, glycopeptides containing single N-acetyl-D-glucosamine...