A5102933372- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Advancements in Battery Materials
- Immunotherapy and Immune Responses
- Respiratory viral infections research
- Virus-based gene therapy research
- Advanced Battery Materials and Technologies
- SARS-CoV-2 detection and testing
- Thyroid Disorders and Treatments
- Traditional Chinese Medicine Studies
- Parasite Biology and Host Interactions
- Supercapacitor Materials and Fabrication
- Viral Infections and Vectors
- Virology and Viral Diseases
- Semiconductor materials and devices
- Healthcare and Venom Research
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Parasitic Infections and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Helminth infection and control
- Neonatal Health and Biochemistry
- Monoclonal and Polyclonal Antibodies Research
- Parasites and Host Interactions
- Electromagnetic wave absorption materials
University of Chinese Academy of Sciences
2017-2024
Wuhan Institute of Virology
2021-2024
Chinese Academy of Sciences
2017-2024
Guangdong Ocean University
2007-2024
Nanchang University
2023
Jiangxi Maternal and Child Health Hospital
2021-2023
Xiamen University
2020-2022
Shenzhen University
2022
Guangzhou Huashang College
2021
Beijing University of Chinese Medicine
2011-2019
The mechanisms responsible for the inhibitory effects of mesenchymal stem cells (MSCs) on dendritic (DCs) are still poorly understood. Our investigation potential signaling pathways revealed first time that human umbilical-cord-derived MSCs (UC-MSCs) instruct DCs to acquire tolerogenic phenotypes through IL-6-mediated upregulation SOCS1. This subset MSC-DCs exhibited a pattern, with clear decrease in expression co-stimulatory molecules and capacity stimulate CD3(+) T cell proliferation...
Diabetes severely impairs male reproduction. The present study assessed the effects and mechanisms of action advanced glycation end products (AGEs), which play an important role in development diabetes complications, on testosterone secretion by rat Leydig cells. Primary cells were cultured treated with AGEs (25, 50, 100 200 µg/ml). Testosterone production induced human chorionic gonadotropin (hCG) was determined ELISA. mRNA protein expression levels steroidogenic acute regulatory (StAR),...
Tilapia (Oreochromis mossambicus) skin high value-added compounds have not been fully utilized in tilapia processing. Here, the protective effects of peptides (TSP) on primary ovarian failure (POF) and their underlying mechanisms mice were investigated. Cyclophosphamide (CP) was injected intraperitoneally (ip) for 14 days (10 mg kg-1 d-1) to establish a mouse model POF. At same time, given intragastrically (ig) TSP 30 (250 d-1, 500 1000 respectively). The index, estrous cycle, hormone level,...
Current SARS-CoV-2 Omicron subvariants impose a heavy burden on global health systems by evading immunity from most developed neutralizing antibodies and vaccines. Here, we identified nanobody (aSA3) that strongly cross-reacts with the receptor binding domain (RBD) of both SARS-CoV-1 wild-type (WT) SARS-CoV-2. The dimeric construct aSA3 (aSA3-Fc) tightly binds potently neutralizes WT Based X-ray crystallography, engineered bispecific dimer (2-3-Fc) fusing aSA3-Fc to aRBD-2, previously...
This study was conducted to explore the effects of squid ink on growth performance, immune functions and antioxidant ability broiler chickens during a period six weeks.Either sex Arbor Acres broilers were equally allotted 4 groups with 3 replicates 20 each.Broilers diets for test prepared separately starter finisher phases.Control fed basal diet birds group Exp 2, 6 supplemented 2%, 4% 6% ink, respectively.Broilers sacrificed investigate parameters sera, indices thymus, spleen bursa...
Anxiety- and depression-like behavior following chemotherapy treatment occurs in cancer patients with high probability no specific therapeutics are available for prevention of this complication. Here, tilapia skin peptides (TSP), a novel enzymatically hydrolyzed bioactive peptide mixture, obtained from ( Oreochromis mossambicus ) scraps, were studied on cyclophosphamide (CP)-induced anxiety- mice. Mice received intraperitoneal injection CP 2 weeks, while TSP was administered 4 weeks. After...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still rapidly spreading worldwide. Many drugs and vaccines have been approved for clinical use show efficacy in the treatment prevention of SARS-CoV-2 infections. However, emergence variants concern (VOCs), such as Delta (B.1.617.2) recently emerged Omicron (B.1.1.529), has seriously challenged application current therapeutics. Therefore, there a pressing need identification new broad-spectrum antivirals. Here, we...
The combination of Euphorbia kansui Liou ex S.B.Ho (kansui) and Glycyrrhiza uralensis Fisch (liquorice) is contraindicated in Chinese medicine, but whether it can be used clinical practice remains controversial. classic formula, Gansui Banxia decoction (GBD), contains liquorice, which effective treating an abnormal accumulation body fluids, such as malignant ascites (MA); however, the contraindications liquorice have limited its application. This study aims to provide a theoretical basis for...
Abstract CD99 is a 32‐kDa transmembrane glycoprotein that encoded by the MIC2 gene. Our study was carried out to examine role of in tumor progression classical Hodgkin lymphoma (cHL). Here, we showed lowly expressed protein cHL cell lines and primary cases correlates with deficient expression positive regulatory domain 1 (PRDM1/BLIMP1). In addition, high levels miR‐9 expression. We determined upregulation induced transcription factor PRDM1, master regulator plasma‐cell differentiation, which...
Continuous Fe-SiC fibers with the highest Fe content of 7.70 wt% were successfully fabricated and exhibit excellent EMW absorbing performance. The microstructure possesses SiC crystallites, turbostratic carbon, x Si y @C.
Abstract The pandemic of COVID-19 caused by SARS-CoV-2 has raised a new challenges to the scientific and industrious fields after over 1-year spread across different countries. ultimate approach end is timely application vaccines achieve herd immunity. Here, novel receptor-binding domain (RBD) homodimer was developed as vaccine candidate. Formulated with aluminum adjuvant, RBD dimer elicited strong immune response in both rodents non-human primates, protected mice from challenge...
During the two-year pandemic of coronavirus disease 2019 (COVID-19), its causative agent, severe acute respiratory syndrome 2 (SARS-CoV-2), has been evolving. SARS-CoV-2 Delta, a variant concern, become dominant circulating strain worldwide within just few months. Here, we performed comprehensive analysis new B.1.617.2 Delta (Delta630) compared with early WIV04 (WIV04) in vitro and vivo, terms replication, infectivity, pathogenicity, transmission hamsters. When inoculated intranasally,...
MicroRNAs (miRNAs) recruit the RNA-induced silencing complex (RISC) to repress translation of target mRNAs. While 5′ 7-methylguanosine cap mRNAs has been well known be important for miRNA repression, underlying mechanism is not clear. Here we show that TNRC6A interacts with eIF4E2, a homologue eIF4E can bind but cannot interact eIF4G initiate translation, inhibit Downregulation eIF4E2 relieved repression reporter expression. Moreover, downregulation increased protein levels endogenous IMP1,...
Nano-Si can alleviate the structural damage caused by volume expansion while ensuring high reversible lithium storage capacity. However, abundant specific surface area and unique unbonded electronic properties at of nanoparticles make them suffer from complex side reactions an agglomeration phenomenon. Here, strategies based on modification are developed to enhance performance nano-Si anodes. Through in situ grafting SiOC coating, a stable high-energy Si–O–Si covalent bond is formed between...
Abstract Silicon is considered as the desirable anode material for lithium‐ion batteries due to its suitable discharge potential, abundant reserve, and ultra‐high specific capacity. However, poor conductivity unstable battery performance caused by large volume change during cycling limit further development of silicon anode. In order avoid solid electrolyte interface layer direct contact between electrolyte, eliminate structural collapse cycling, dimension size reduction, reserved voids,...
Poor intrinsic conductivity and the presence of irreversible lithiation phase affect electrochemical performance silicon oxycarbide anode materials. Even though it can be improved by increasing free carbon content or composition, scarification reversible capacity initial Coulombic efficiency (ICE) remain as challenge. Here, polycarbosilane (PCS) with alternating distribution atoms is employed precursor SiOC ceramics. Air oxidation cross-linking used to regulate oxygen elements in PCS at atom...
Haizao Yuhu Decoction has been widely used to treat thyroid-related diseases especially goiter with few side effects in traditional Chinese medicine (TCM), including herb pair Sargassum (HZ) and Glycyrrhizae Radix et Rhizoma (GC), as one of "eighteen antagonistic medicaments." The two different species Sargassum, fusiforme (Sf) pallidum (Sp), are not clearly differentiated clinical use, so that Sf-GC Sp-GC could show effect toxicity.We investigated the antigoitrous toxicity clarified...
Abstract Neutralizing antibodies (NAbs) can prevent and treat infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, continuously emerging variants, such as Omicron, have significantly reduced the potency of most known NAbs. The selection NAbs with broad neutralizing activities identification conserved critical epitopes are still urgently needed. Here, we identified an extremely potent antibody (55A8) single B-cell sorting from convalescent...
Peste des petits ruminants (PPR) is a contagious and fatal disease of sheep goats. PPR virus (PPRV) infection induces endoplasmic reticulum (ER) stress-mediated unfolded protein response (UPR). The activation UPR signaling pathways their impact on apoptosis replication remains controversial.
BACKGROUNDAs Omicron is prompted to replicate in the upper airway, neutralizing antibodies (NAbs) delivered through inhalation might inhibit early-stage infection respiratory tract. Thus, elucidating prophylactic efficacy of NAbs via nasal spray addresses an important clinical need.METHODSThe applicable potential a cocktail containing 2 was characterized by testing its potency, synergetic mechanism, emergency protective and therapeutic hamster model, pharmacokinetics/pharmacodynamic (PK/PD)...