A5100653684- Moringa oleifera research and applications
- Mycorrhizal Fungi and Plant Interactions
- Fungal Biology and Applications
- Autophagy in Disease and Therapy
- Proteins in Food Systems
- Wound Healing and Treatments
- Cellular Mechanics and Interactions
- Forest Ecology and Biodiversity Studies
- Parkinson's Disease Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Nuclear Receptors and Signaling
- Mycobacterium research and diagnosis
- Infectious Diseases and Mycology
- Obsessive-Compulsive Spectrum Disorders
- Gut microbiota and health
- Mitochondrial Function and Pathology
- Eating Disorders and Behaviors
- Probiotics and Fermented Foods
- Hepatitis C virus research
- Essential Oils and Antimicrobial Activity
- Hepatitis B Virus Studies
- Protein Hydrolysis and Bioactive Peptides
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Fungal Infections and Studies
Westlake University
2025
Hangzhou First People's Hospital
2023-2025
Army Medical University
2015-2024
Daping Hospital
2020-2024
Yunnan Agricultural University
2012-2024
Wenzhou Medical University
2011-2024
Zhengzhou University of Light Industry
2024
Sichuan University
2019-2023
West China Hospital of Sichuan University
2019-2023
University of Chinese Academy of Sciences
2021-2023
Parkinson disease (PD) is an age-related neurodegenerative disorder associated with misfolded SNCA/α-synuclein accumulation in brain. Impaired catabolism of SNCA potentiates formation its toxic oligomers. LRRK2 (leucine-rich repeat kinase-2) mutations predispose to familial and sporadic PD. Mutant perturbs chaperone-mediated-autophagy (CMA) degrade SNCA. We showed greater age-dependent oligomeric striatum cortex aged LRRK2R1441G knockin (KI) mice, compared age-matched wildtype (WT) by 53%...
The proliferation and differentiation of intestinal stem cells (ISCs) are the basis renewal regeneration, gut microbiota plays an important role in it. Dietary nutrition has effect regulating activity ISCs; however, regulation α-linolenic acid (ALA) seldom been reported.After intervening mice with different doses ALA for 30 days, it is found that (0.5 g kg-1 ) promotes small villus growth by activating Wnt/β-catenin signaling pathway to stimulate ISCs. Furthermore, administration increases...
To investigate the efficacy and safety of IV infusion tirofiban before endovascular thrombectomy for patients with large vessel occlusion due to intracranial atherosclerotic disease. The secondary objective was identify potential mediators clinical effect tirofiban.
Moringa oleifera Lam. leaves are a new raw food material rich in polysaccharides. These polysaccharides exhibit various biological properties, including antioxidant, hypoglycemic and immunoregulatory effects. However, the use of (MOLP) may be limited by their large molecular weight (MW) presence numerous impurities, such as pigments. Research has indicated that degraded usually high activity because changes physical structure chemical properties. In this study, we focused on extraction...
This study focuses on developing a water-in-oil-in-water (W
Arbuscular mycorrhizal and dark septate endophytic fungal colonization in a grassland Kunming, southwest China, was investigated monthly over one year. All plant roots surveyed were co-colonized by arbuscular fungi this grassland. Both fluctuated significantly throughout the year, their seasonal patterns different each species. The relationships between environmental (climatic edaphic) factors also studied. Correlation analysis demonstrated that correlative with (rainfall, sunlight hours,...
Abstract Excessive activation of inflammation and the accompanying lung vascular endothelial barrier disruption are primary pathogenic features acute injury (ALI). Microtubule-associated protein 4 (MAP4), a tubulin assembly-promoting protein, is important for maintaining microtubule (MT) cytoskeleton cell-cell junctional structures. However, both involvement exact mechanism MAP4 in development ALI remains unknown. In this study, lipopolysaccharide (LPS) tumour necrosis factor-α (TNF-α) were...
Wound healing is delayed frequently in patients with diabetes. Proper keratinocyte migration an essential step during re-epithelialization. Impaired a critical underlying factor responsible for the deficiency of diabetic wound healing, which mainly attributed to hyperglycemic state. However, mechanisms remain largely unknown. Previously, we demonstrated marked activation p38/mitogen-activated protein kinase (MAPK) pathway regenerated migrating epidermis, turn promoted migration. In present...
The dermal fibroblast is a crucial executor involved in wound healing, and lipopolysaccharide key factor initiating the migration proliferation of fibroblasts, followed by healing. However, underlying molecular mechanism still unknown. In this study, we demonstrated that stathmin increased concomitantly with p38/MAPK pathway activation stimulation human (HDF), which induced microtubule (MT) depolymerization HDF proliferation. contrast, application taxol, small interfering RNA transfection...
The communities of arbuscular mycorrhizal fungi (AMF) colonizing the roots Bothriochloa pertusa, Cajanus cajan and Heteropogon contortus in a fallow land (FL) an undisturbed (UL) were characterized. large subunit rDNA genes AMF from amplified cloned. A total 2353 clones screened by restriction fragment length polymorphism, 428 subsequently sequenced. 393 sequences, which grouped into 100 operational taxonomic units, obtained. Phylogenetic analysis revealed that sequences belonged to Glomus,...
In recent years, obesity has become a key factor affecting human health. Moringa oleifera Lam. is perennial tropical deciduous tree, which widely used in medicine due to its nutritional and unique medicinal value. It cholesterol-lowering effect, but mechanism of action unclear. this study, we elucidated the inhibitory effect M. leaf petroleum ether extract (MOPEE) on lipid accumulation by vitro vivo experiments, described action. MOPEE suppressed adipogenesis 3T3-L1 adipocytes dose-dependent...
Abstract BNIP3 is an atypical BH3-only member of the Bcl-2 family with pro-death, pro-autophagic, and cytoprotective functions, depending on type stress cellular context. Recently, we demonstrated that stimulates migration epidermal keratinocytes under hypoxia. In present study found autophagy expression were concomitantly elevated in migrating epidermis during wound healing a hypoxia-dependent manner. Inhibition through lysosome-specific chemicals (CQ BafA1) or Atg5-targeted...
Astragalin is a flavonoid found in variety of natural plants. It has anti-inflammatory, anti-oxidant effects and inhibited against several malignant tumor cell types. However, its on colon cancer the molecular mechanisms have remained to be elucidated. In this study, we evaluated inhibitory effect astragalin proliferation migration human HCT116 cells vitro vivo . Furthermore, elucidated mechanism these effects. The results showed that significantly diffusion by induced apoptosis (by...
Moringa oleifera seed protein hydrolysates exhibit good hypoglycemic activity, but their specific peptide components have not yet been characterized. Here, we identified the ultrafiltration (<3 kDa) of M. hydrolysates. A highly active α-glucosidase inhibitory with an IC50 value 109.65 μM (MoHpP-2) amino acid sequence KETTTIVR was identified. We characterized its structural properties, stability, and activity. MoHpP-2 found to be amphipathic a β-turn structure, hemolysis red blood cells...
Moringa oleifera is a commonly used plant with high nutritional and medicinal values. M. leaves are considered new food resource in China. However, the biological activities of polysaccharides (MOP) regulating gut microbiota alleviating obesity remain obscure. In present study, we prepared MOP evaluated its effects on high-fat diet (HFD)-induced C57BL/6J mice. The experimental mice were supplemented normal chow (NCD group), (HFD HFD along at different dose 100, 200, 400 mg/kg/d,...
Moringin [4-(α-L-rhamnosyloxy) benzyl isothiocyanate] is an isothiocyanate from Moringa oleifera seeds. It the bioactivated form of glucosinolate precursor glucomoringin with various health benefits. However, few studies have examined antibacterial activity moringin. This study aimed to investigate antimicrobial and mechanism moringin against Listeria monocytogenes. The minimum inhibitory concentration (MIC), growth curves were used evaluate bacteriostatic effect L. Transcriptome analysis by...
Cranberries (Vaccinium macrocarpon) are full of polyphenols, which display various health benefits. Most studies have focused on extractable polyphenols (EPs) rather than non-extractable (NEPs) but NEPs may possess important biological functions. The objective this work was to characterize EP and NEP fractions from whole cranberries determine their potential as anti-inflammation anti-colon-cancer agents. Our results showed that the identified anthocyanins were major ones in cranberry...
BackgroundCardiac remodeling is a pathophysiological process that involves various changes in heart, including cardiac hypertrophy and fibrosis. Cardiac following pathological stimuli common trigger leading to maladaptation onset of heart failure, their pathogenesis remains unclear.MethodsHeart specimens tetralogy Fallot (TOF) patients, myocardial infarction (MI) transverse aortic constriction (TAC) mouse models were collected determine microtubule associated protein 4 (MAP4)...
Both cell migration and proliferation are indispensable parts of reepithelialization during skin wound healing, which is a complex process for the underlying molecular mechanisms largely unknown.Here, we identify novel role microtubule-associated protein 4 (MAP4), cytosolic microtubule-binding that regulates microtubule dynamics through phosphorylation modification, as critical regulator epidermal repair.We showed MAP4 was induced in wounds.In an aberrant phosphorylated mouse model,...