A5028698116- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Fungal Infections and Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Intestinal Malrotation and Obstruction Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Antifungal resistance and susceptibility
- Neurosurgical Procedures and Complications
- Cardiac Valve Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Congenital gastrointestinal and neural anomalies
- Clinical Nutrition and Gastroenterology
- Congenital Diaphragmatic Hernia Studies
- Infective Endocarditis Diagnosis and Management
- Esophageal and GI Pathology
- Infant Nutrition and Health
- Congenital Anomalies and Fetal Surgery
- Cancer-related molecular mechanisms research
- Nail Diseases and Treatments
- Enhanced Recovery After Surgery
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cerebrospinal fluid and hydrocephalus
Nanjing Medical University
2011-2025
Shanghai Changzheng Hospital
2017-2025
Nantong University
2025
Taizhou People's Hospital
2025
Tianjin Medical University General Hospital
2019-2024
Chinese Academy of Fishery Sciences
2022-2024
Second Affiliated Hospital of Nanjing Medical University
2017-2024
Soochow University
2024
Hefei University of Technology
2024
Jilin Electric Power Research Institute (China)
2024
Abstract Background Severe patients with 2019 novel coronavirus (2019-nCoV) pneumonia progressed rapidly to acute respiratory failure. We aimed evaluate the definite efficacy and safety of corticosteroid in treatment severe COVID-19 pneumonia. Methods Forty-six hospitalized at Wuhan Union Hospital from January 20 February 25, 2020, were retrospectively reviewed. The divided into two groups based on whether they received treatment. clinical symptoms chest computed tomography(CT) results...
Abstract Subdural haematomas (SDHs) are characterized by rapidly or gradually accumulated between the arachnoid and dura mater. The mechanism of haematoma clearance has not been clearly elucidated until now. meningeal lymphatic vessel (mLV) drainage pathway is a novel system that takes part in waste products central nervous (CNS). This study aimed to explore roles mLV SDH its impacting factors. We injected FITC-500D, A488-fibrinogen autologous blood into subdural space mice/rats found these...
Abstract The persistent dysregulation and accumulation of poisonous proteins from destructive neural tissues cells activate pathological mechanisms after traumatic brain injury (TBI). lymphatic drainage system the brain, composed glymphatic meningeal vessels (MLVs), plays an essential role in clearance toxic waste injury. neuroprotective effect interleukin 33 (IL-33) TBI mice has been demonstrated; however, its impact on is unclear. Here, we established a fluid percussion model to examine...
In recent years, obesity has become a key factor affecting human health. Moringa oleifera Lam. is perennial tropical deciduous tree, which widely used in medicine due to its nutritional and unique medicinal value. It cholesterol-lowering effect, but mechanism of action unclear. this study, we elucidated the inhibitory effect M. leaf petroleum ether extract (MOPEE) on lipid accumulation by vitro vivo experiments, described action. MOPEE suppressed adipogenesis 3T3-L1 adipocytes dose-dependent...
Introduction Candida auris is an emerging multidrug-resistant fungus that may cause infections with a high mortality rate. The first case of C. infection was reported in 2009 and have been 44 countries. now represents major global public health threat. We analyzed cases from the emergence up until end 2020. It hoped results this analysis will raise awareness scientists to promote protection control research pertaining pathogen. Methods PubMed Web Science databases were searched for all...
The glymphatic-lymphatic fluid transport system (GLFTS) consists of glymphatic pathway and cerebrospinal (CSF) lymphatic outflow routes, allowing biological liquids from the brain parenchyma to access CSF along with perivascular space be cleaned out skull through vessels. It is known that increased local pressure due physical compression tissue improves in peripheral organs, but little about exact relationship between intracranial (IICP) GLFTS. In this study, we verify our hypothesis IICP...
Rationale: Percutaneous endoscopic transforaminal lumbar interbody fusion (PE-TLIF) is a minimally invasive surgical approach for the treatment of degenerative diseases, Due to high incidence complications and long operative time, cases reported in previous literature were focused on single segment diseases. In our study, we present 2 patients who had continuous double-level degenerated disease. Patient concerns: A 71-year-old man with severe low back pain right leg 3 months, 57-year-old...
Hirschsprung's disease (HSCR) is a rare congenital caused by impaired proliferation and migration of neural crest cells. We investigated changes in expression microRNAs (miRNAs) the genes they regulate tissues patients with HSCR. Quantitative real-time PCR immunoblot analyses were used to measure levels miRNA, mRNAs, proteins colon from 69 HSCR 49 individuals without (controls). Direct interactions between miRNAs specific mRNAs indentified vitro, while function role miR-218-1 was using...
Abstract This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression ascertain the involvement of signaling melanoma. We show that is abundant human samples, elevated linked acquisition increased metastatic invasive potential. Importantly, we observed a significant correlation between activity FAK its phosphorylation at Ser 910 site. Mechanistically, transcription factor USF1, which could transcriptionally upregulate expression, resulting activation...
This study investigated the anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity and chemical compositions of ether extracts from Rhizoma Polygoni Cuspidati (ET-RPC). Significant anti-MRSA activities ET-RPC against MRSA252 MRSA clinical strains were tested in vitro antibacterial experiments, such as inhibition zone diameter test, minimal inhibitory concentration dynamic bacterial growth assay. Subsequently, 7 major compounds purified identified polydatin,...
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases worldwide. In this study, we investigated role miR-146b in Toll-like receptor-4 signaling pathway and high-fat diet (HFD)-induced NASH vivo vitro.The effect on expression IL-1 receptor-associated kinase 1 (IRAK1) tumor necrosis factor 6 (TRAF6) RAW264.7 cells HepG2 was studied, lipid accumulation also studied vitro. The levels IRAK1, TRAF6, NF-κB, pro-inflammatory cytokines, as well histologic features...
Candida auris, C. haemulonii, duobushaemulonii, and pseudohaemulonii are closely related highly multidrug resistant yeast pathogens. The high cost low accuracy of current diagnostics may underestimate their prevalence, especially in medical resource-limited regions. In this study, we used 172 auris stains its relatives 192 other fungal strains to establish validate a novel multiplex end-point PCR. A prospective retrospective clinical screenings using assay were further performed China Iran...
Summary Diabetes mellitus II ( DM ) is a newly defined independent factor contributing to the morbidity and mortality of cryptococcosis. This retrospective case analysis aims explore epidemiology, clinical profile strain characteristics cryptococcosis in Chinese patients. study included 30 cases with occurring from 1993 2015 mainland China. The hospital‐based prevalence was 0.21%. mean age patients 56.1 years (95% confidence interval: 51.5, 60.6), 93% were older than 40 years. Sixty‐two per...
Abstract Background Evidence supports an association between cholestatic liver disease and changes in microbiome composition. Nevertheless, the identification of this special type biliary atresia from non-biliary cholestasis is still a major clinical difficulty. The purpose study to compare differences composition gut infants with infant atrestic cholestasis, find new ways identify diagnose these two diseases early, understand influence presence or absence bile on cholestasis. Methods Using...
This study investigated naturally-restored plant communities on wind farm slopes and analyzed the effects of various habitat factors diversity. The findings provide a technical support for ecological restoration mountainous slopes.Twenty-one five farms were selected characteristics habitat, including slope position, aspect, gradient, altitude, years since restoration, communities, recorded. species richness vegetation diversity indexes these measured calculated, Shannon-Wiener index (H'),...
Background: The farnesoid X receptor (FXR) is a key factor regulating hepatic bile acid synthesis and enterohepatic circulation. Repression of by the FXR potential strategy for treating cholestatic liver disease. However, role intestinal on barrier microbiota needs further investigation. Materials: Intestinal tissues were collected from patients with biliary atresia or without hepatobiliary Then, mRNA levels FXR-related molecules determined. To investigate effect activation,...
The presented study examines the chemical composition and antioxidant activity of petroleum ether fraction Rosmarinus officinalis (PEF-RO), which was obtained via 75 % ethanol extraction followed by extraction. fractions were analyzed gas chromatography-mass spectrometry (GC-MS). in vitro PEF-RO investigated using various assays, including 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulfonate (ABTS) free radical scavenging, ferric reducing power (FRAP)...
Introduction and aim. Patients with NASH have increased risk for sepsis or cardiovascular disease after Liver transplantation. An important role of Toll-like receptor (TLR) 4 in the pathogenesis nonalcoholic steatohepatitis (NASH) was demonstrated. Here, we study miR-182-5p TLR4 expression high-fat-diet (HFD)-induced vitro vivo Material methods. Following transfection a mimic, effect on RAW264.7 HepG2 cells investigated. administration mimic into livers HFD-induced mice, determined TLR4,...