A5101667366- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Tryptophan and brain disorders
- Natural product bioactivities and synthesis
- Genomics and Rare Diseases
- Stress Responses and Cortisol
- Cardiac Valve Diseases and Treatments
- Aortic Thrombus and Embolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Associations and Epidemiology
- Corneal surgery and disorders
- Sepsis Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Traditional Chinese Medicine Studies
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- PARP inhibition in cancer therapy
- COVID-19 Impact on Reproduction
- Telomeres, Telomerase, and Senescence
- RNA and protein synthesis mechanisms
Valve (United States)
2024
Minneapolis Heart Institute Foundation
2024
Chengdu University of Traditional Chinese Medicine
2021-2024
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Nanjing Maternity and Child Health Care Hospital
2023
Nanjing Medical University
2013-2023
Chinese Academy of Sciences
2020-2022
Huazhong University of Science and Technology
2013-2022
Union Hospital
2013-2022
Many studies suggest that trimethylamine-N-oxide (TMAO), a gut-flora-dependent metabolite of choline, contributes to the risk cardiovascular diseases, but little is known for non-alcoholic fatty liver disease (NAFLD). We examined association circulating TMAO, choline and betaine with presence severity NAFLD in Chinese adults. performed hospital-based case-control study (CCS) cross-sectional (CSS). In CCS, we recruited 60 biopsy-proven cases 35 controls (18-60 years) determined serum...
Abstract Background Severe patients with 2019 novel coronavirus (2019-nCoV) pneumonia progressed rapidly to acute respiratory failure. We aimed evaluate the definite efficacy and safety of corticosteroid in treatment severe COVID-19 pneumonia. Methods Forty-six hospitalized at Wuhan Union Hospital from January 20 February 25, 2020, were retrospectively reviewed. The divided into two groups based on whether they received treatment. clinical symptoms chest computed tomography(CT) results...
Novel coronavirus disease (COVID-19) is spreading globally. Little known about the risk factors for clinical outcomes of COVID-19 in children.A retrospective case-control study was taken children with severe acute respiratory syndrome coronary virus-2 infection Wuhan Children's Hospital. Risk associated development and progression were collected analyzed.Eight 260 diagnosed pneumonia included study. Thirty-five matched age, sex date admission, who classified as non-severe type, randomly...
Background Diabetes has been found to increase severity and mortality under the current pandemic of coronavirus disease 2019 (COVID-19). Up date, clinical characteristics diabetes patients with COVID-19 risk factors for poor outcomes are not clearly understood. Methods The study was retrospectively carried out on enrolled laboratory confirmed infection from a designated medical center January 25th, 2020 February 14th, in Wuhan, China. record collected reviewed. Univariate multivariate...
Increasing the provitamin A content in staple crops via carotenoid metabolic engineering is one way to address vitamin deficiency. In this work a combination of methods was applied specifically increase β-carotene wheat by engineering. Endosperm-specific silencing hydroxylase gene (TaHYD) increased 10.5-fold 1.76 μg g–1 endosperm. Overexpression CrtB introduced an additional flux into wheat, accompanied 14.6-fold 2.45 g–1. When "push strategy" (overexpressing CrtB) and "block (silencing...
Activation of nuclear receptor estrogen α (ERα) exerts cardiovascular protective effects by modulating the expression ERα target genes. However, underlying mechanism remains unclear. PARP1 is a ubiquitous multifunctional enzyme. In this study, we examined interplay between and ERα, identified as an important regulator ERα-dependent transcription. We showed that could directly bind to be poly(ADP-ribosyl)ated PARP1. Poly(ADP-ribosyl)ation increased binding response element (ERE) present in...
Background: Every year, nearly 170,000 people die from bladder cancer worldwide. A major problem after transurethral resection of tumor is that 40–80% the tumors recur. Ferroptosis a type regulatory necrosis mediated by iron-catalyzed, excessive oxidation polyunsaturated fatty acids. Increasing sensitivity cells to ferroptosis potential treatment option for cancer. Establishing diagnostic and prognostic model based on ferroptosis-related genes may provide guidance precise Methods: We...
The association between inflammatory cytokines and the risk of post-stroke depression (PSD) remains unclear. aim present study was to investigate this effect PSD on outcomes ischemic stroke patients. A total 355 patients who had experienced participated in cytokine detection by ELISA, addition depression, quality life (QOL) body performance testing. Cox regression used evaluate associations risk, Measurement data evaluated using Student's t test, counted measured χ2 test. incidence during...
Background: In lung transplantation surgery, extracorporeal life support (ECLS) is essential for safety. Various methods, including cardiopulmonary bypass (CPB) and off-pump techniques, are used, with membrane oxygenation (ECMO) gaining prominence. However, consensus on the best strategy lacking. Purpose: This article reviews risks, benefits, outcomes of different strategies in transplantation. By consolidating knowledge, it aims to clarify selecting most appropriate ECLS modality. Research...
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease characterized by localized dilation of the abdominal aorta. C1q/tumor necrosis factor (TNF)-related protein-13 (CTRP13) secreted adipokine that plays important roles in system. However, functional role CTRP13 formation and development AAA has yet to be explored. In this study, we determined serum levels were significantly downregulated blood samples from patients with rodent models induced Angiotensin II (Ang II)...
Runs of homozygosity (ROHs) are a class important but poorly studied genomic variations and may be in-volved in individual susceptibility to diseases. To better understand ROH its relationship with lung cancer, we performed genome-wide analysis subset previous case-control study (1,473 cases 1,962 controls) Han Chinese population. ROHs were classified into two classes, based on lengths, intermedi-ate long ROHs, evaluate their association cancer risk using existing single nucleotide...