A5101477459- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Liver Disease and Transplantation
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and biological activity of medicinal plants
- Natural product bioactivities and synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Studies
- Plant-based Medicinal Research
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Liver Diseases and Immunity
- Lipid metabolism and disorders
- Atherosclerosis and Cardiovascular Diseases
- Medicinal Plants and Bioactive Compounds
- Rheumatoid Arthritis Research and Therapies
- Alcohol Consumption and Health Effects
- Flavonoids in Medical Research
- Diet, Metabolism, and Disease
- Healthcare and Venom Research
- Cancer-related molecular mechanisms research
Liaoning University of Traditional Chinese Medicine
2021-2025
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2021-2025
Chengdu University of Traditional Chinese Medicine
2017-2024
Southwestern Institute of Physics
2021-2023
Ministry of Education of the People's Republic of China
2022
Beijing Institute of Technology
2014
Abstract Liver fibrosis is a progressive pathological process induced by various stimuli and may progress to liver cirrhosis cancer. Forsythiaside A (FA) an active ingredient extracted from traditional Chinese medicine Forsythiae Fructus has prominent hepatoprotective activities. However, the unsatisfactory pharmacokinetic properties restrict its clinical application. In this study, nanocarrier of CD44‐specific ligand Hyaluronic acid (HA)‐modified milk‐derived exosomes (mExo) encapsulated...
Liver fibrosis is a chronic and progressive disease with complex pathogenesis related to bile acids (BAs) gut microbiota. Forsythiaside A (FTA), isolated from the traditional Chinese medicine Forsythiae Fructus (Lian Qiao), natural hepatoprotective agent. The purpose of this study was investigate protective effect FTA on carbon tetrachloride (CCl4)-induced liver in mice. induced mice by intraperitoneal injection 2 mL/kg CCl4 three times week for 4 weeks. attenuated CCl4-induced mice, which...
Liver fibrosis (LF) is an important stage in chronic liver disease development, characterized by hepatic stellate cell (HSC) activation and excessive extracellular matrix deposition. Phillygenin (PHI), active component the traditional Chinese medicine Forsythiae Fructus with a significant anti-inflammatory effect, has been proved to inhibit HSC activation. Macrophages can polarize pro-inflammatory M1 phenotype M2 phenotype, participating LF development. Currently, its many components have...
Objective: This study aimed to investigate the potential mechanisms and biomarkers between Obesity (OB) carotid atherosclerosis (CAS). Methods: The GSE12828, GSE125771, GSE43292, GSE100927 datasets were combined normalized obtain CAS-related differentially expressed genes (DEGs), OB-related DEGs obtained from GSE151839 dataset GeneCards database. Unsupervised cluster analysis was conducted on CAS samples based of OB. Subsequently, immune infiltration gene set enrichment (GESA) performed. 61...
Liver fibrosis is a chronic pathological process that various pathogenic factors lead to abnormal hyperplasia of hepatic connective tissue, and its main feature the excessive deposition extracellular matrix. However, there are currently no drugs approved for treatment liver fibrosis. Phillygenin (PHI), lignan isolated from Forsythiae Fructus, showed potential anti-inflammatory anti-fibrosis effects but mechanisms remain unknown. In view vital role gut microbiota in development fibrosis, this...
Abstract Background Inflammation is a general pathological phenomenon during severe disturbances to the homeostasis. Forsythiaside A (FA) and forsythiaside B (FB), isolated from dried fruit of Forsythia suspensa (Thunb.) Vahl, are phenylethanoid compounds that show significant anti-inflammatory effect. However, properties therapeutic mechanisms this effect have not yet been systematically elucidated. Methods In study, effects FA FB were investigated in CuSO 4 -induced inflammation zebrafish...
Nonalcoholic fatty liver disease (NAFLD) has become a predictor of death in many diseases. This study was carried out to investigate the therapeutic effect Radix Polygoni Multiflori Preparata (RPMP) and its main component emodin on egg yolk powder-induced NAFLD zebrafish. Further investigation performed explore whether RPMP for treatment as well underlying mechanism emodin.Zebrafish were divided into control group, powder group group. The obesity zebrafish evaluated by body weight, length...
Abstract This study aims to investigate the mechanism of anti‐atherosclerosis effect Huayu Qutan Recipe (HYQT) on inhibition foam cell formation. In vivo, mice were randomly divided into three groups: CTRL group, MOD group and HYQT group. The received oral administration twice a day (20.54 g/kg/d), plaque formation in ApoE −/− was observed using haematoxylin–eosin (HE) staining oil red O (ORO) staining. co‐localization aortic macrophages lipid droplets (LDs) examined fluorescent labelling...
Abstract Non-alcoholic steatohepatitis (NASH) is a hepatocyte inflammation based on hepatocellular steatosis, yet there no effective drug treatment. Atherosclerosis (AS) caused by lipid deposition in the endothelium, which can lead to various cardiovascular diseases. NASH and AS share common risk factors, also elevate of AS, causing higher morbidity mortality rate for atherosclerotic heart disease. Therefore, timely detection diagnosis are particularly important. In this study, differential...