A5066824693- Sperm and Testicular Function
- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Cancer-related molecular mechanisms research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Congenital gastrointestinal and neural anomalies
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Toxic Organic Pollutants Impact
- Birth, Development, and Health
- Heavy Metal Exposure and Toxicity
- Pesticide Exposure and Toxicity
- Gut microbiota and health
- Carcinogens and Genotoxicity Assessment
- Energy and Environment Impacts
- Climate Change and Health Impacts
- Epigenetics and DNA Methylation
- Sexual Differentiation and Disorders
- Health, Environment, Cognitive Aging
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Per- and polyfluoroalkyl substances research
- Pregnancy and preeclampsia studies
- RNA modifications and cancer
Nanjing Medical University
2016-2025
Center for Global Health
2025
Ministry of Education of the People's Republic of China
2014-2024
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
State Key Laboratory of Reproductive Medicine
2014-2024
Chongqing University
2024
Wuxi People's Hospital
2024
Southeast University
2024
Center for Disease Control
2024
The evaluation of the chemical impact on human health is usually constrained to analysis effects exposure a single or group similar chemicals at one time. mixtures are seldom analyzed. In this study, we applied three statistical models assess association between mixture seven xenobiotics (three phthalate metabolites, two phenols, and pesticides) obesity. Urinary levels environmental pesticides, metabolites were measured in adults who participated U.S.-based National Health Nutrition...
Autism Spectrum Disorder (ASD) is a severe neurodevelopmental disorder. To enhance the understanding of gut microbiota structure in ASD children at different ages as well relationship between and fecal metabolites, we first used 16S rRNA sequencing to evaluate microbial population cohort 143 aged 2–13 years old. We found that α-diversity group showed no significant change with age, while TD increased which indicates compositional development varies ways are not consistent group. Recent...
Environmental microparticle is becoming a global pollutant and the entire population increasingly exposed to microparticles from artificial materials. The accumulation of including microplastics its subsequent effects need be investigated timely keep sustainable development human society.This study aimed explore environmental particles in thrombus, pathological structure blood circulation system.Patients receiving cardiovascular surgical operations were screened twenty-six thrombi collected,...
Microplastics are plastic fragments widely distributed in the environment and accumulate organisms. However, research on microplastics effects mammals is limited. Polyethylene main kind of environment. We hypothesized that polyethylene exposure disrupts host intestine metabolism by modifying microflora composition then lipopolysaccharide (LPS) pathway. Female mice were orally exposed to 0, 0.002 0.2 μg/g/d (PE MPs) for 30 days. Colon mucin density was quantized after AB-PAS staining. Mucin 2...
// Lei Peng 1, 3, * , Guanglin Chen Zhongxian Zhu Ziyang Shen 3 Chunxia Du Rujin Zang Yang Su Hua Xie Hongxing Li Xiaoqun Xu Yankai Xia 2 Weibing Tang 1 State Key Laboratory of Reproductive Medicine, Institute Toxicology, School Public Health, Nanjing Medical University, China Modern Ministry Education, Department Pediatric Surgery, Children’s Hospital These authors contributed equally to this work Correspondence to: Tang, email: twbcn@163.com Keywords: hirschsprung disease, circular...
Exogenous microparticles including microplastics are novel pollutants that could persist in the environment with potential health effects, while crucial data on their exposure humans still lacking. To understand panorama of and distribution characteristics different kinds body fluids. A non-targeted microparticle internal landscape analysis was done thirteen human enclosed fluids covering eight systems. Totally 104 patients aged 24–96 years an average age 56 were included this study. After...
Background Gestational diabetes mellitus (GDM) is one type of that presents during pregnancy and significantly increases the risk a number adverse consequences for fetus mother. The microRNAs (miRNA) have recently been demonstrated to abundantly stably exist in serum be potentially disease-specific. However, no reported study investigates associations between miRNA GDM. Methodology/Principal Findings We systematically used TaqMan Low Density Array followed by individual quantitative reverse...
Pyrethroid insecticides, the most commonly used insecticides worldwide, are suspected endocrine-disrupting chemicals. But their interactions with hormone receptors still unclear. The present study intended to evaluate and compare receptor (estrogen [ER], androgen [AR], thyroid [TR]) activities of nine pyrethroids (cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin, deltamethrin, etofenprox, fenvalerate, permethrin, tetramethrin) metabolites (3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropne...
The dopamine transporter is the primary means of inactivating synaptic as well a major site action for psychostimulants (such cocaine and amphetamine) neurotoxins that induce parkinsonism. In present study, human partial cDNA clone obtained by polymerase chain reaction exhibited 87% 89% identity at nucleic acid amino levels, respectively, with transmembrane domains 3-5 rat homolog. This was used to quantitate mRNA nuclease protection assay. postmortem content in substantia nigrae 18-...
Perfluorooctane sulfonate (PFOS) is a widespread and persistent chemical in the environment. We investigated endocrine-disrupting effects of PFOS using combination vitro vivo assays. Reporter gene assays were used to detect receptor-mediated (anti-)estrogenic, (anti-)androgenic, (anti-)thyroid hormone activities. The effect on steroidogenesis was assessed both at levels supernatant expression hormone-induced genes H295R cell. A zebrafish-based short-term screening method developed endocrine...
Abstract Cancer-testis ( CT ) genes represent the similarity between processes of spermatogenesis and tumorigenesis. It is possible that their selective expression pattern can help identify driver in cancer. In this study, we integrate transcriptomics data from multiple databases systematically 876 new 19 cancer types. We explore relationship with testis-specific regulatory elements. propose extremely highly expressed (EECTGs) are potential drivers activated through epigenetic mechanisms....
Abnormal germline DNA methylation in males has been proposed as a possible mechanism compromising spermatogenesis of some men currently diagnosed with idiopathic infertility. Previous studies have focused on imprinted genes poor quality human sperms. However, recent but limited data revealed that sperm abnormalities may involve large numbers or shown are not also affected.Using the methylation-specific polymerase chain reaction and bisulfite sequencing method, we examined patterns promoter...
MicroRNAs (miRNAs) are small non-coding RNAs (18-25 nt), playing important regulatory roles via interaction with cellular messenger RNAs. The altered expression of miRNAs in specific tissues has been associated diseases such as cancer and diabetes. We examined the presence two selected (miR-19b let-7a) human seminal plasma from fertile men idiopathic infertile patients oligozoospermia non-obstructive azoospermia (NOA) using quantitative real-time PCR. detected humans. levels were...
Childhood obesity increases susceptibility to type 2 diabetes (T2D) in adults. Circulating microRNAs (miRNAs) serum have been proposed as potential diagnostic biomarkers, and they may contribute the progression toward T2D. Here, we investigated possibility of predicting future risk adult T2D obese children by using circulating miRNAs.We performed miRNA high-throughput sequencing screen relevant miRNAs children. The expression patterns targeted were further explored adults with To investigate...
What is the profile of miRNAs in seminal plasma patients with non-obstructive azoospermia (NOA)? miR-141, miR-429 and miR-7-1-3p are significantly increased NOA compared fertile controls. There currently an urgent need to develop a noninvasive diagnostic test for NOA. Altered microRNA (miRNA) profiles have been proposed as potential biomarkers diagnosis disease states. A total 200 subjects (n = 100 NOA, n control) were recruited participate this study. Recruitment took place from May 2008...
Enhancer RNAs (eRNAs) are a group of lncRNAs transcribed from enhancers, whose regulatory effects on gene expression an emerging area interest. However, the role eRNAs in regulating trophoblast cells and unexplained recurrent pregnancy loss (URPL) remains elusive.We profiled villi URPL patients matched controls by RNA-seq. Functions URPL-related were further investigated vitro.We identified lnc-SLC4A1-1, which was active enhancer marked with H3K27ac H3K4me1 so-called eRNA, highly expressed...