A5101411402- Nitric Oxide and Endothelin Effects
- Neurological Disease Mechanisms and Treatments
- Estrogen and related hormone effects
- Effects and risks of endocrine disrupting chemicals
- Renin-Angiotensin System Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Ischemia and Reperfusion
- Advanced Glycation End Products research
- Menopause: Health Impacts and Treatments
- Acute Ischemic Stroke Management
- Cardiac electrophysiology and arrhythmias
- Takotsubo Cardiomyopathy and Associated Phenomena
- Receptor Mechanisms and Signaling
- Toxic Organic Pollutants Impact
- Eicosanoids and Hypertension Pharmacology
- Glaucoma and retinal disorders
- Cancer-related molecular mechanisms research
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Fibrosis and Remodeling
- Mitochondrial Function and Pathology
- Sulfur Compounds in Biology
- Neurological Disorders and Treatments
- Circular RNAs in diseases
- Sphingolipid Metabolism and Signaling
- Cardiovascular Health and Disease Prevention
Xuzhou Medical College
2016-2025
Nanjing Medical University
2014-2025
Jiangsu Province Hospital
2013-2025
Jiangsu Provincial Center for Disease Control and Prevention
2009-2025
ZheJiang Academy of Agricultural Sciences
2025
Louisiana State University Health Sciences Center Shreveport
2014-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Hebei North University
2024
Louisiana State University Health Sciences Center New Orleans
2018-2023
Background— Takotsubo cardiomyopathy is an acute heart failure syndrome characterized by myocardial hypocontractility from the mid left ventricle to apex. It precipitated extreme stress and can be triggered intravenous catecholamine administration, particularly epinephrine. Despite its grave presentation, rapidly reversible, with generally good prognosis. We hypothesized that this represents switching of epinephrine signaling through pleiotropic β 2 -adrenergic receptor (β AR) canonical...
Abstract Sepsis‐induced myocardial dysfunction (SIMD) causes high mortality in seriously ill patients. Ginsenoside Rg1 has been proven to have effective anti‐inflammatory and antiapoptotic properties. However, the specific role of SIMD molecular mechanism remain unclear. Hence, we aimed investigate latent effects ginsenoside against explore its underlying mechanisms. Male C57BL/6J mice neonatal rat cardiomyocytes (NRCMs) were used as vivo vitro models, respectively. Western blot analysis was...
Pyrethroid insecticides, the most commonly used insecticides worldwide, are suspected endocrine-disrupting chemicals. But their interactions with hormone receptors still unclear. The present study intended to evaluate and compare receptor (estrogen [ER], androgen [AR], thyroid [TR]) activities of nine pyrethroids (cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin, deltamethrin, etofenprox, fenvalerate, permethrin, tetramethrin) metabolites (3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropne...
ABSTRACT Objective : Our goal was to identify the role of oxidative stress via activation NAD(P)H oxidase in cerebrovascular dysfunction aged rats. Methods We examined reactivity cerebral arterioles adult and Fisher‐344 rats endothelial nitric oxide synthase (eNOS)‐dependent (acetylcholine adenosine diphosphate [ADP]) and‐independent (nitroglycerin) agonists before during application tempol, apocynin, diphenyleneiodonium chloride (DPI). used Western blot examine subunits oxidase, eNOS,...
Luteolin, a naturally occurring polyphenol flavonoid, has demonstrated to exert myocardial protection effects. However, the mechanisms have not been fully elucidated. In present study, we investigated whether luteolin pretreatment was associated with cardioprotection in rat ischemia/reperfusion (I/R) model. Luteolin significantly only restored contractility of left ventricle, but also reduced infarct size and lactate dehydrogenase leakage during I/R. addition, improved cardiomyocyte...
Background: Inflammation and oxidative stress play a crucial role in the pathogenesis of renal ischemia/reperfusion injury (IRI). Maresin 1 (MaR1), which has shown strong anti-inflammatory antioxidant effects, was recently reported to have protective properties several different animal models. Aim: The objectives our study were determine whether MaR1 alleviates IRI identify underlying mechanisms. Materials methods: mouse model this induced by ischemia left kidney for 45 minutes nephrectomy...
Th17 cells and interleukin-17 (IL-17) have been found to play an important role in the pathology of multiple sclerosis (MS) its animal model, experimental autoimmune encephalomyelitis (EAE). Response IL-17, reactive astrocytes accompany with immune infiltration axonal damage MS/EAE. However, regulatory mechanism IL-17-activated inflammation EAE process still remain largely unknown. Here, we elucidated that miR-409-3p miR-1896, as co-upregulated microRNAs activated mice, targeted suppressor...
Electrophilic aldehyde (4-hydroxynonenal; 4-HNE), formed after lipid peroxidation, is a mediator of mitochondrial dysfunction and implicated in both the pathogenesis progression cardiovascular disease. Manganese superoxide dismutase (MnSOD), nuclear-encoded antioxidant enzyme, catalyzes dismutation radicals (O2•-) mitochondria. To study role MnSOD myocardium, we generated cardiomyocyte-specific SOD2 (SOD2Δ) deficient mouse strain. Unlike global knockout mice, SOD2Δ mice reached adolescence;...
Background — We have observed direct (noncatecholamine-blocking) negative inotropic effects of the selective β 2 -adrenoceptor (AR) antagonist ICI 118,551 in myocytes from failing human ventricle. In this study we characterize effect parallel and animal models where ARs or G i proteins are overexpressed. Methods Results Enzymatically isolated, superfused ventricular were exposed to βAR agonists antagonists/inverse agonists, contraction amplitude was measured. decreased hearts by 45.3±4.1%...
Di-n-butyl phthalate (DBP) is an endocrine-disrupting chemical that has the potential to affect male reproduction.However, reproductive effects of low-dose DBP are still not well known, especially at molecular level.In present study, pubertal Sprague-Dawley rats were orally administered a wide range doses (0.1, 1.0, 10, 100 and 500 mg kg 21 day ) for 30 days.The selected end points included organ weights, testicular histopathology serum hormonal levels.Additionally, proteomic analysis was...
Decreased dilation of cerebral arterioles via an increase in oxidative stress may be a contributing factor the pathogenesis diabetes-induced complications leading to cognitive dysfunction and/or stroke. Our goal was determine whether resveratrol, polyphenolic compound present red wine, has protective effect on during type 1 diabetes (T1D). We measured responses untreated and resveratrol-treated (10 mg·kg(-1)·day(-1)) nondiabetic diabetic rats endothelial (eNOS) neuronal (nNOS) nitric oxide...
The role of nitric oxide synthases (NOSs) in early blood-brain barrier (BBB) disruption was determined using a new mouse model transient focal cerebral ischemia. Ischemia induced by ligating the middle artery (MCA) at its M2 segment and reperfusion releasing ligation. diameter alteration MCA, arterial anastomoses collateral arteries were imaged measured real time. BBB assessed Evans Blue (EB) sodium fluorescein (Na-F) extravasation 3 hours reperfusion. produced an extensive vasodilation...
Acute lung injury (ALI) is an important cause of morbidity and mortality for critically ill patients, linarin (LR) may be a potential treatment ALI as it reportedly has antioxidant, anti‑inflammatory apoptotic‑regulating activity. In the present study, authors report that saline LR (12.5, 25 50 mg/kg) were applied to male C57BL/6 mice via gavage. Then, intratracheally injected with either or lipopolysaccharide (LPS). LR‑pretreatment attenuated LPS‑induced platelet activation reduced CD41...
MicroRNAs (miRNAs) have been shown to function as either oncogenes or tumor suppressors by negatively regulating target genes involved in initiation and progression. In this study, we demonstrated that down-regulation of miR-33a-3p human primary hepatocellular cancer (HCC) specimens was significantly associated with metastases poor survival. Over-expression HepG2 cells remarkably suppressed not only cell growth, migration invasion, but also growth the chick embryo chorioallantoic membrane...