A5065410562- Lymphatic System and Diseases
- Hippo pathway signaling and YAP/TAZ
- Sympathectomy and Hyperhidrosis Treatments
- Planarian Biology and Electrostimulation
- Adaptive optics and wavefront sensing
- Pregnancy and preeclampsia studies
- Vascular Malformations and Hemangiomas
- Congenital heart defects research
- Wnt/β-catenin signaling in development and cancer
- Lymphatic Disorders and Treatments
- Renal and related cancers
- Cancer-related Molecular Pathways
- Birth, Development, and Health
- Neurogenesis and neuroplasticity mechanisms
- IL-33, ST2, and ILC Pathways
- Optical Systems and Laser Technology
- Developmental Biology and Gene Regulation
- Ubiquitin and proteasome pathways
- Marine and coastal ecosystems
- Pancreatic function and diabetes
- Skin and Cellular Biology Research
- Connexins and lens biology
- Marine Toxins and Detection Methods
- Gastric Cancer Management and Outcomes
- Optical Wireless Communication Technologies
Jinan University
2021-2025
Institute of Hydrobiology
2021-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Institute of Optics and Electronics, Chinese Academy of Sciences
2022-2024
Chinese Academy of Sciences
2007-2024
University of Chinese Academy of Sciences
2022-2024
University of South Florida
2018-2024
Xi'an Institute of Optics and Precision Mechanics
2023
National Center for Drug Screening
2022-2023
The homeobox gene Prox1 is crucial for mammalian lymphatic vascular development. In the absence of Prox1, endothelial cells (LECs) are not specified. maintenance LEC identity also requires constant expression Prox1. However, mechanisms controlling this in LECs remain poorly understood. SRY-related Sox18 required to induce venous progenitors. Although expressed embryonic arteries, these vessels do express nor they give rise LECs. This finding suggests that some cell-specific factor activation...
The mammalian lymphatic vasculature is important for returning fluids from the extracellular tissue milieu back to blood circulation. We showed previously that Prox1 dosage development of vasculature. lack activity results in complete absence endothelial cells (LECs). In heterozygous embryos, number LECs reduced because a decrease progenitor pool cardinal vein. This reduction caused by some being unable maintain expression. this study, we identified Vegfr3 , cognate receptor lymphangiogenic...
The lymphatic vasculature requires intraluminal valves to maintain forward lymph flow. Lymphatic form and are constantly maintained by oscillatory fluid flow throughout life, yet the earliest steps of how endothelial cells able respond shear stress remain unknown. Here, we show that adherens junction protein VE-cadherin is required for upregulation valve-specific transcription factors. Conditional deletion in vivo prevented valve formation embryo caused postnatal regression nearly all...
In the face of mounting environmental issues, people around world are reporting experience difficult emotions such as anxiety and worry, or what is increasingly referred to eco-anxiety. It often acknowledged that symptoms eco-anxiety can range in severity fall along a continuum. Such proposition has important implications, it may help explain why some forms more mal(adaptive) than others. five studies (Total N = 2939) across three countries (Canada, China, United Kingdom), we examined how...
Retinoblastoma (Rb)-deficient embryos show severe defects in neurogenesis, erythropoiesis, and lens development die at embryonic day 14.5. Our recent results demonstrated a drastic disorganization of the labyrinth layer placenta Rb-deficient embryos, accompanied by reduced placental transport function. When these Rb-/- were supplied with wild-type using either tetraploid aggregation or genetic approaches, animals survived until birth. Here we analyze role extraembryonic Rb regulating...
Th17 cells and interleukin-17 (IL-17) have been found to play an important role in the pathology of multiple sclerosis (MS) its animal model, experimental autoimmune encephalomyelitis (EAE). Response IL-17, reactive astrocytes accompany with immune infiltration axonal damage MS/EAE. However, regulatory mechanism IL-17-activated inflammation EAE process still remain largely unknown. Here, we elucidated that miR-409-3p miR-1896, as co-upregulated microRNAs activated mice, targeted suppressor...
We describe a model for early onset preeclampsia (EOPE) that uses induced pluripotent stem cells (iPSCs) generated from umbilical cords of EOPE and control (CTL) pregnancies. These iPSCs were then converted to placental trophoblast (TB) representative pregnancy. Marker gene analysis indicated both sets differentiated at comparable rates. The tested parameters disturbed in EOPE, including invasive potential. Under 5% O 2 , CTL TB lines did not differ, but, under hyperoxia (20% ), invasiveness...
During implantation, cytotrophoblasts undergo epithelial-to-mesenchymal transition (EMT) as they differentiate into invasive extravillous trophoblasts (EVTs). The primate-specific microRNA cluster on chromosome 19 (C19MC) is exclusively expressed in the placenta, embryonic stem cells and certain cancers however, its role EMT gene regulation unknown. In situ hybridization for miR-517a/c, a C19MC cistron microRNA, first trimester human placentas displayed strong expression villous gradual...
Patients with congenital lymphedema suffer from tissue swelling in part due to mutations genes regulating lymphatic valve development. Lymphatic leaflets grow and are maintained throughout life response oscillatory shear stress (OSS), which regulates gene transcription endothelial cells (LECs). Here, we identified the first factor, Foxo1, that repressed formation by inhibiting expression of valve-forming genes. We showed both embryonic postnatal ablation Foxo1 LECs induced additional adult...
During formation of the mammalian placenta, trophoblasts invade maternal decidua and remodel spiral arteries to bring blood into placenta. This process, known as endovascular invasion, is thought involve adoption functional characteristics vascular endothelial cells (ECs) by trophoblasts. The genetic molecular basis invasion remains poorly defined, however, whether utilize specialized proteins in an analogous manner create channels untested. Vascular (VE-)cadherin a homotypic adhesion...
HIV-associated neurocognitive disorders (HANDs) afflict more than half of HIV-1-positive individuals. The transactivator transcription (Tat) produced by HIV virus elicits inflammatory process and is a major neurotoxic mediator that induce neuron damage during HAND pathogenesis. Activated astrocytes are important cells involved in neuroinflammation neuronal damage. Purinergic receptors expressed participate positive feedback loop virus-induced neurotoxicity. Here, we investigated whether...
Lymphatic capillaries develop discontinuous cell-cell junctions that permit the absorption of large macromolecules, chylomicrons, and fluid from interstitium. While excessive vascular endothelial growth factor 2 (VEGFR2) signaling can remodel seal these junctions, whether how VEGFR3 alter lymphatic remains incompletely understood. Here, we use lymphatic-specific Flt4 knockout mice to investigate in junctions. We show loss prevents specialized button junction formation multiple tissues...
HPV16 is the predominant type of HPV causing invasive cervical cancer. However, underlying molecular mechanism unparalleled carcinogenic power compared to other types high‐risk (HR)‐HPV including HPV18 remains elusive. The PDZ binding motif (PBM) E6 plays an important role in neoplasia and progression rather than E6, interacted with NHERF1 by its PBM region, induced degradation NHERF1. retarded assembly cytoskeleton downregulation ACTN4, thereby inhibited migration invasion cancer cells both...
Lymphatic malformations (LMs) are lesions due to inherited or somatic mutations that lead a defective lymphatic vasculature. Activating KRAS have been identified recently in LM patients with lymphedema, chylous ascites, life-threatening chylothorax. In mouse model, associated loss of valves, which has proposed cause chylothorax via retrograde lymph flow into the pleural space. However, mechanisms underlying valves unknown. To investigate leading valve loss, we combined lymphatic-specific and...