A5100337059- Metabolism, Diabetes, and Cancer
- Endometrial and Cervical Cancer Treatments
- Cancer-related Molecular Pathways
- Pancreatic function and diabetes
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Diabetes Treatment and Management
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Allergic Rhinitis and Sensitization
- Ocular Surface and Contact Lens
- Breast Cancer Treatment Studies
- Intraperitoneal and Appendiceal Malignancies
- Ocular Infections and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Peroxisome Proliferator-Activated Receptors
- Advanced Breast Cancer Therapies
- Medical Research and Treatments
- FOXO transcription factor regulation
- Pancreatic and Hepatic Oncology Research
- Surgical site infection prevention
- Cancer Genomics and Diagnostics
Lanzhou University Second Hospital
2020-2025
Sun Yat-sen University
2012-2024
Sun Yat-sen Memorial Hospital
2003-2024
Guangzhou Medical University
2023-2024
State Key Laboratory of Respiratory Disease
2024
Third Affiliated Hospital of Guangzhou Medical University
2024
Lanzhou University
2020-2023
SUNY Upstate Medical University
2023
South China University of Technology
2023
Guangzhou First People's Hospital
2023
MEDI2070 is a human monoclonal antibody that selectively inhibits interleukin 23 (IL23), cytokine implicated in the pathogenesis of Crohn's disease (CD). We analyzed its safety and efficacy treatment CD phase 2a study.We conducted double-blind, placebo-controlled study 119 adults with moderate to severe failed by tumor necrosis factor antagonists. Patients were randomly assigned (1:1) groups given (700 mg) or placebo intravenously at weeks 0 4. received open-label (210 subcutaneously every 4...
A challenge of chronic diseases that remains to be solved is how liberate patients and medical resources from the burdens long-term monitoring periodic visits. Precise management based on artificial intelligence (AI) holds great promise; however, a clinical application fully integrates prediction telehealth computing has not been achieved, further efforts are required validate its real-world benefits. Taking congenital cataract as representative, we used Bayesian deep-learning algorithms...
<h3>Importance</h3> Allergic conjunctivitis (AC) is one of the most common allergic diseases and especially problematic in children adolescents. The course AC generally prolonged often recurs. Understanding health-related quality life (QOL) both with their parents would be useful. <h3>Objective</h3> To evaluate association between QOL parents. <h3>Design, Setting, Participants</h3> A prospective case-control study was conducted at Zhongshan Ophthalmic Center, a single tertiary referral...
Background: The characteristics of established risk factors for breast cancer may vary among countries. A better understanding local help in devising effective prevention strategies cancer.Methods: Information on exposures to was collected from the medical charts 4211 women with diagnosed during 1999–2008. distributions these regions, and by menopausal status birth period, were compared χ2 test. Crude associations between selected estimated using cases present study a representative control...
<b><i>Objectives:</i></b> The present study tested the hypothesis that pretreatment with metformin decreases postprocedural myocardial injury and improves clinical outcomes in metabolic syndrome patients following percutaneous coronary intervention (PCI). <b><i>Methods:</i></b> We enrolled 152 no prior history of treatment. Patients scheduled for elective were randomized to or control group 7 days before procedure. Creatine kinase-MB (CK-MB)...
Liver kinase B (LKB) 1 acts as a tumor suppressor in broad spectrum of human cancers, and is important chemoradiotherapy treatment various types. However, the potential function LKB1 esophageal cancer radiotherapy remains to be elucidated. The aim present study was investigate role radiosensitivity vivo vitro, explore its molecular mechanism. Eca‑109 cells transfected with overexpression plasmid were xenografted into nude mice subjected irradiation it observed that volume significantly...
This study explores the effects of prenatal exposure to air pollution on risk macrosomia and its window susceptibility. We conducted a retrospective cohort utilizing records birth certificates for all full-term live newborns born in Xi'an city, China from January 1, 2015, December 31, 2018.Weekly- trimester-specific exposures PM2.5, PM10, NO2, O3 during pregnancy were calculated by inverse distance weighting (IDW) based their residences. Cox proportional hazard model distributed lag models...
GLUT4 (glucose transporter 4) plays important roles in glucose homoeostasis vivo. expression and function are diminished diabetic human animal subjects. The goal of the present study is to develop a cell-based assay for identifying negative regulators translocation as potential targets treatment Type 2 diabetes. Traditional assays performed differentiated myocytes or adipocytes difficult perform, particularly HTS (high-throughput screening) mode. In study, we stably co-expressed c-Myc eGFP...
Abstract For locally advanced cervical cancer ( LACC ), hypoxia is a characteristic property. This study aimed to investigate whether baseline lactic dehydrogenase LDH ) level, which marker of hypoxia, had clinical value in determining neoadjuvant chemotherapy NACT response and prognosis for patients. The cohort included 418 patients with median follow‐up 37.5 months. Cox proportional hazards models were used assess the prognostic levels. Multivariate logistic regression analysis was...
Objectives: The objective of this study was to summarize the rate lymph node metastasis (LNM) patients with stage IA–IIA cervical cancer and further analyze its distribution characteristics related risk factors. Design: This is a retrospective analysis clinical data about cancer. Participants: According International Federation Gynecology Obstetrics (FIGO) 2009 staging standard, 975 treated in our hospital from January 2010 December 2018. Setting: single-center study. Methods: incidence LNM...