A5060760755- Neonatal Respiratory Health Research
- Wastewater Treatment and Nitrogen Removal
- Advanced MEMS and NEMS Technologies
- Preterm Birth and Chorioamnionitis
- Neonatal and Maternal Infections
- Plant Molecular Biology Research
- Acoustic Wave Resonator Technologies
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- Urinary Bladder and Prostate Research
- Electronic Packaging and Soldering Technologies
- Water Treatment and Disinfection
- Photosynthetic Processes and Mechanisms
- Carbohydrate Chemistry and Synthesis
- Epigenetics and DNA Methylation
- Photonic and Optical Devices
- Plant Reproductive Biology
- Bladder and Urothelial Cancer Treatments
- Inflammasome and immune disorders
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Membrane Separation Technologies
- Antibiotic Resistance in Bacteria
- Nanowire Synthesis and Applications
Nanjing University of Chinese Medicine
2025
China Medical University
2025
Huashan Hospital
2025
Fudan University
2025
Nanjing Medical University
2015-2024
Jiangsu Province Hospital
2024
Qingdao University
2023-2024
Huaian First People’s Hospital
2012-2023
Northwest Women's and Children's Hospital
2019-2023
Cornell University
2022-2023
Plant shoot branching is pivotal for developmental plasticity and crop yield. The formation of branch meristems regulated by several key transcription factors including REGULATOR OF AXILLARY MERISTEMS1 (RAX1), RAX2, RAX3. However, the regulatory network still largely unknown. Here, we report identification EXCESSIVE BRANCHES1 (EXB1), which affects axillary meristem (AM) initiation bud activity. Overexpression EXB1 in gain-of-function mutant exb1-D leads to severe bushy dwarf phenotypes,...
Plants display thermomorphogenesis in response to high temperature (HT). PHYTOCHROME INTERACTING FACTOR 4 (PIF4) is a central integrator regulated by numerous negative regulators. However, the mechanisms underpinning PIF4 positive regulation are largely unknown. Here, we find that TEOSINTE BRANCHED 1/CYCLOIDEA/PCF 5 (TCP5), TCP13, and TCP17 transcription factors promote activity of at transcriptional post-transcriptional levels. TCP5 rapidly induced HT treatment, protein stability increases...
Studies investigating the relationship between maternal passive smoking and risk of preterm birth have reached inconsistent conclusions. A cohort study that included 10,095 nonsmoking women who delivered a singleton live was carried out in Lanzhou, China, 2010 2012. Exposure to during pregnancy associated with an increased very (<32 completed weeks gestation; odds ratio = 1.98, 95% confidence interval: 1.41, 2.76) but not moderate (32–36 0.98, 0.81, 1.19). Risk duration exposure (P for trend...
Cancer is ranked as one of the top killers in all human diseases and continues to have a devastating effect on population around globe. Current research efforts are aiming accelerate our understanding molecular basis cancer develop effective means for diagnostics, treatment prognosis. An altered pattern epigenetic modifications, most importantly DNA methylation events, plays critical role tumorigenesis through regulating oncogene activation, tumor suppressor gene silencing chromosomal...
Acute lung injury (ALI) is an important cause of morbidity and mortality for critically ill patients, linarin (LR) may be a potential treatment ALI as it reportedly has antioxidant, anti‑inflammatory apoptotic‑regulating activity. In the present study, authors report that saline LR (12.5, 25 50 mg/kg) were applied to male C57BL/6 mice via gavage. Then, intratracheally injected with either or lipopolysaccharide (LPS). LR‑pretreatment attenuated LPS‑induced platelet activation reduced CD41...
Human urinary bladder cancer (UBC) is the fourth most common and eighth cause of death in USA. High mobility group box 3 (HMGB3), a member family proteins containing one or more high DNA binding motifs, was reported to be overexpressed variety human cancers. However, expression role HMGB3 UBC remains unclear. Here, we found that patients had upregulated HMGB at both mRNA protein levels. Immunochemistry (IHC) evaluation 113 clinical specimens showed positive correlation with tumor size (P =...
High levels of the post-translational modification O-GlcNAcylation (O-GlcNAc) are found in multiple cancers, including bladder cancer. Autophagy, which can be induced by stress from modifications, plays a critical role maintaining cellular homeostasis and regulating tumorigenesis. The impact on autophagy cancer remains unclear. Here, we evaluate change autophagic activity response to explore potential mechanisms.O-GlcNAcylation cells were altered through pharmacological or genetic...
Traditional fibrous membranes employed in guided tissue regeneration (GTR) the treatment of periodontitis have limitations bioactive and immunomodulatory properties. We fabricated a novel nTPG/PLGA/PCL membrane by electrospinning which exhibit excellent hydrophilicity, mechanical properties biocompatibility. In addition, we investigated its regulatory effect on polarization macrophages facilitating periodontal both vivo vitro. These findings showed 0.5%TPG/PLGA/PCL may inhibit RAW 264.7 into...
The stigma is the entry point for sexual reproduction in plants, but mechanisms underlying development are largely unknown. Here, we disrupted putative auxin biosynthetic and signaling genes to evaluate their roles rice (Oryza sativa) development. Disruption of PINOID (OsPID) gene completely eliminated stigmas, overexpression OsPID led overproliferation suggesting that a key determinant Interestingly, ospid mutants did not display defects flower initiation, nor they develop any pin-like...
Objectives: We investigated the incidence and outcome of clinical histological chorioamnionitis (CA) associated risk factors in an emerging provincial perinatal center 2014–2015.Study design: Based on suspected proven infection third trimester pregnancy, placenta accessories from singleton deliveries were routinely examined histologically. The CA fetal neonatal compared by total deliveries.Results: Of 14,166 12 months, inflammation found 373 out 2372 (15.7%) placentas subjected to...
Background Cutaneous melanoma is a type of malignant tumor that challenging to predict and readily stimulated by various factors. Oxidative stress can induce damage alterations in melanocytes, subsequently triggering immune responses. Given oxidative prevalent stimulus, we aimed enhance prediction identifying lncRNA signatures associated with stress. Methods We screened for stress-related lncRNAs could improve patient prognosis using the TCGA GTEx databases. Utilizing differentially...
Abstract Liver fibrosis, a common pathological process, severely impacts human health, yet effective treatments are lacking. Cuproptosis, newly discovered form of cell death induced by copper ions, triggers cytotoxic stress through sulfenylated protein oligomerization and may offer novel therapeutic strategy for liver fibrosis. However, the mechanisms underlying cuproptosis in fibrosis not well understood. During progression, hepatic stellate cells (HSCs) activate, proliferate, secrete...
The aim of this study was to investigate the relationship between fascin and cortactin protein expression clinicopathological parameters survival time in patients with hepatocellular carcinoma (HCC).A total 77 specimens HCC seven normal liver tissues were collected. expressions examined by immunohistochemical staining. from whom HCCs taken also followed up. In these 74 patients, Kaplan-Meier used assess outcomes.The data revealed that upregulated samples. positive significantly correlated...
The molecular mechanism of how airway inflammation develops is not fully understood. Withaferin A (WA) a natural phytochemical isolated from the plant Withania somnifera. It well-investigated bioactive compound that possesses variety health-promoting effects, including anti-inflammatory and anti-oxidative activities. In present study, effect WA on ovalbumin (OVA)-induced in mice was investigated. results indicated pre-treatment with inhibited OVA-induced lung injury fibrosis progression...
Antibiotic tolerance, the ability of bacteria to sustain viability in presence typically bactericidal antibiotics for extended time periods, is an understudied contributor treatment failure. The Gram-negative pathogen Vibrio cholerae, causative agent cholera, becomes highly tolerant β-lactam (penicillin and related compounds) a process requiring two-component system VxrAB. VxrAB induced by exposure cell wall damaging conditions, which results differential regulation >100 genes. While...
This study focused on the start-up and operating characteristics of endogenous partial denitrification (EPD) process with different carbon sources. Two sequencing batch reactors (SBRs) sodium acetate (SBR1#) glucose (SBR2#) as sources were operated under anaerobic/oxic (A/O) anaerobic/anoxic/oxic (A/A/O) modes successively for 240 d. The results showed that COD removal efficiency reached 85% effluent concentrations below 35 mg/L in both SBRs. difference was faster absorption transformation...