Xiaohan Guo

ORCID: 0000-0002-0423-9882
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About
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Research Areas
  • Orthodontics and Dentofacial Orthopedics
  • Traditional Chinese Medicine Analysis
  • Oral microbiology and periodontitis research
  • Gut microbiota and health
  • Metabolomics and Mass Spectrometry Studies
  • Dental Health and Care Utilization
  • Dental Implant Techniques and Outcomes
  • Advanced Chemical Sensor Technologies
  • Dental materials and restorations
  • Temporomandibular Joint Disorders
  • Chromatography in Natural Products
  • Venous Thromboembolism Diagnosis and Management
  • Facial Rejuvenation and Surgery Techniques
  • Blood Coagulation and Thrombosis Mechanisms
  • Spectroscopy and Chemometric Analyses
  • Liver Disease Diagnosis and Treatment
  • Taxation and Compliance Studies
  • Food Quality and Safety Studies
  • Acute Myocardial Infarction Research
  • Wound Healing and Treatments
  • Advanced Sensor and Energy Harvesting Materials
  • Ferroptosis and cancer prognosis
  • Covalent Organic Framework Applications
  • Immunotherapy and Immune Responses
  • Natural product bioactivities and synthesis

National Institutes for Food and Drug Control
2018-2025

The Ohio State University
2020-2025

Harbin Engineering University
2024-2025

Ministry of Industry and Information Technology
2024-2025

Beijing Institute of Technology
2024-2025

Nanjing University of Chinese Medicine
2025

Shandong University
2022-2025

Xuzhou Medical College
2024-2025

Pfizer (United States)
2023-2024

Women's Hospital, School of Medicine, Zhejiang University
2015-2024

Adaptive immunity of prokaryotes is mediated by CRISPR-Cas systems that employ a large variety Cas protein effectors to identify and destroy foreign genetic material. The different targeting mechanisms proteins rely on the proper protection host genome sequence while allowing for efficient detection target sequences, termed protospacers. A short DNA sequence, protospacer-adjacent motif (PAM), frequently used mark sites. have evolved multitude PAM-interacting domains, which enables them cope...

10.1080/15476286.2018.1504546 article EN cc-by RNA Biology 2018-08-15

Abstract Artificial skin, endowed with the capability to perceive thermal stimuli without physical contact, will bring innovative interactive experiences into smart robotics and augmented reality. The implementation of touchless thermosensation, responding both hot cold stimuli, relies on construction a flexible infrared detector operating in long‐wavelength range capture spontaneous radiation. This imposes rigorous requirements photodetection performance mechanical flexibility detector....

10.1002/adma.202313911 article EN Advanced Materials 2024-03-01

Immunotherapy especially immune checkpoint inhibitors (ICIs) has brought favorable clinical results for numerous cancer patients. However, the efficacy of ICIs in colorectal (CRC) is still unsatisfactory due to poor median progression-free survival and overall survival. Here, based on CRC models, we tried elucidate novel relapse mechanisms during anti-PD-1 therapy. We found that PD-1 blockade elicited a mild antitumor effect these tumor models with both increased CD8+ T cells Treg cells....

10.3389/fimmu.2022.947756 article EN cc-by Frontiers in Immunology 2022-08-08

Abstract Background The oral microbiota is acquired very early, but the factors shaping its acquisition are not well understood. Previous studies comparing monozygotic (MZ) and dizygotic (DZ) twins have suggested that host genetics plays a role. However, all share an equal portion of their parent’s genome, so this model informative for studying parent-to-child transmission. We used novel study design allowed us to directly examine transmission by biological versus adoptive mother-child...

10.1186/s40168-020-00986-8 article EN cc-by Microbiome 2021-02-23

Noncontact interactive technology provides an intelligent solution to mitigate public health risks from cross-infection in the era of COVID-19. The utilization human radiation as a stimulus source is conducive implementation low-power, robust noncontact human-machine interaction. However, low intensity emitted by humans puts forward high demand for photodetection performance. Here, SrTiO3-x /CuNi-heterostructure-based thermopile constructed, which features combination thermoelectric...

10.1002/adma.202204355 article EN Advanced Materials 2022-07-12

Natural bioactive components are increasingly being applied in cancer research. Alpinetin is a type of natural flavonoid primarily derived from Alpinia katsumadai Hayata, which exhibits anti‑bacterial and anti‑inflammatory properties. Therefore, it may possess anticancer potential be employed therapeutically for different diseases. The aim the present study was to investigate effects alpinetin on SKOV3 ovarian cell line. effect treatment proliferation, apoptosis, spheroid colony formation...

10.3892/mmr.2018.9420 article EN Molecular Medicine Reports 2018-08-22

This cross-sectional study aimed to examine upper lip (UL) and smile characteristics soft tissue excessive gingival display (EGD) etiologies (hypermobile [HUL], altered passive eruption [APE], short [SUL]) in a nondental adult population analyze interracial (Black White) intersex differences.

10.1002/jper.23-0291 article EN cc-by-nc-nd Journal of Periodontology 2023-07-12

Angelicae sinensis radix (ASR) and pubescentis (APR), as traditional herbal medicines, are often confused doped in the material market. However, identification method is to characterize whole herb with a single or few components, which do not have representation cannot realize effective utilization of unknown components. Consequently, result convincing. In addition, process time-consuming labor-intensive. To avoid confusion adulteration ASR APR well strengthen quality control improve...

10.1021/jasms.4c00254 article EN Journal of the American Society for Mass Spectrometry 2024-08-02

Introduction Brucellosis, an infectious zoonotic disease caused by members of the genus Brucella , results in chronic multi-organ injury. Improving specificity and sensitivity serological methods for diagnosing brucellosis necessitates development novel diagnostic antigens. The twin-arginine translocation (Tat) pathway is responsible transporting folded proteins across cytoplasmic membrane has been implicated virulence . Three Tat substrate proteins—L,D-transpeptidase ErfK (A0577), linear...

10.3389/fvets.2025.1398983 article EN cc-by Frontiers in Veterinary Science 2025-02-05

Culture-specific items, serving as a bridge between two cultures, have long been focal point in translation studies. In 1996, Javier Franco Aixelá proposed widely recognized definition and classification system for culture-specific along with corresponding strategies, significantly advancing research this field. Luotuo Xiangzi, written by Lao She (1899–1966), is one of the most iconic works modern Chinese literature. Since its publication, Xiangzi has garnered...

10.5539/ells.v15n1p55 article EN English Language and Literature Studies 2025-02-24

Background This study aimed to investigate the impact of a comprehensive nursing intervention targeting high water and salt intake on blood pressure volume burden in patients with chronic renal failure.

10.1080/0886022x.2025.2474854 article EN cc-by Renal Failure 2025-03-11

Hypoxia is a key reason for the failure of liver cancer therapy. Emerging evidences indicated that ROS played crucial role in sorafenib therapy, and overcoming reduction intracellular levels was first requirement therapy resistance. Ubiquilin1 (UBQLN1) acted as an oncogene or suppressor gene involved protein degradation abnormal aggregation. In this study, we proposed novel strategy to reverse hypoxia-induced resistance by isoliensinine (Iso), significant bioactive compound derived from...

10.1002/biof.70008 article EN BioFactors 2025-03-01
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