A5013092972- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinal and Optic Conditions
- Peripheral Artery Disease Management
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Meteorological Phenomena and Simulations
- Renal and Vascular Pathologies
- Neurobiology of Language and Bilingualism
- Mast cells and histamine
- MRI in cancer diagnosis
- Heart Failure Treatment and Management
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cardiovascular Syncope and Autonomic Disorders
- Vector-borne infectious diseases
- Tropical and Extratropical Cyclones Research
- Cerebral Palsy and Movement Disorders
- Ocean Waves and Remote Sensing
- Motor Control and Adaptation
- Neonatal and fetal brain pathology
- Precipitation Measurement and Analysis
Zhanjiang Experimental Station
2024
Xinqiao Hospital
2019-2023
Army Medical University
2019-2023
Huadong Hospital
2022-2023
Fudan University
2022-2023
Zhejiang University
2023
Hangzhou First People's Hospital
2023
China Meteorological Administration
2023
Nanjing University
2021-2022
Nanjing General Hospital of Nanjing Military Command
2022
<h3>Importance</h3> For patients with large vessel occlusion strokes, it is unknown whether endovascular treatment alone compared intravenous thrombolysis plus (standard treatment) can achieve similar functional outcomes. <h3>Objective</h3> To investigate thrombectomy noninferior to alteplase followed by for achieving independence at 90 days among stroke. <h3>Design, Setting, and Participants</h3> Multicenter, randomized, noninferiority trial conducted 33 stroke centers in China. Patients (n...
<h3>Importance</h3> Several randomized clinical trials have recently established the safety and efficacy of endovascular treatment (EVT) acute ischemic stroke in anterior circulation. However, it remains uncertain whether patients with basilar artery occlusion (BAO) benefit from EVT. <h3>Objective</h3> To evaluate association between EVT outcomes BAO. <h3>Design, Setting, Participants</h3> This nonrandomized cohort study, for Acute Basilar Artery Occlusion Study (BASILAR) was a nationwide...
To investigate the efficacy and safety of IV infusion tirofiban before endovascular thrombectomy for patients with large vessel occlusion due to intracranial atherosclerotic disease. The secondary objective was identify potential mediators clinical effect tirofiban.
This study aimed to analyze the impact of baseline posterior circulation Acute Stroke Prognosis Early Computed Tomography Score (pc-ASPECTS) on efficacy and safety endovascular therapy (EVT) for patients with acute basilar artery occlusion. The BASILAR was a nationwide prospective registry consecutive symptomatic radiologically confirmed occlusion within 24 hours symptom onset. We estimated effect standard medical alone (SMT group) versus SMT plus EVT (EVT documented pc-ASPECTS noncontrast...
BACKGROUND: The present study aimed to evaluate the efficacy and safety of intravenous tirofiban versus alteplase before endovascular treatment (EVT) in acute ischemic stroke patients with intracranial large vessel occlusion. METHODS: This was a post hoc analysis using data from 2 multicenter, randomized trials: DEVT trial (Direct Endovascular Treatment for Large Vessel Occlusion Stroke) May 2018 2020 RESCUE BT (Intravenous Tirofiban Before Thrombectomy Acute Ischemic October 2021. Patients...
To evaluate the effectiveness and safety of rescue stenting (RS) after failed mechanical thrombectomy (MT) for patients with large artery occlusion in anterior circulation.Consecutive who experienced reperfusion subsequently did or not undergo RS at 16 comprehensive stroke centers were enrolled from January 2015 to June 2018. Propensity score matching was used achieve baseline balance between patient groups. Symptomatic intracranial hemorrhage (sICH) 48 hours modified Rankin Scale scores...
Spotted fever group Rickettsia (SFGR), containing various pathogenic spp., poses remarkable negative influences to public health by causing severe or mild diseases. Information regarding prevalence of SFGR in ticks Jiangsu province, Eastern China, is still limited and needs urgent investigations.Hedgehog- bovine-attached were collected from China. DNA individual was extracted for nested polymerase chain reaction amplifications targeting gltA, 16S ribosomal RNA (rrs), ompA, ompB, sca4 genes...
Abstract It is well known that tropical cyclones (TCs) making landfall in Southern China (SC) account for more than half of all TCs China. Therefore, it important to have an in-depth understanding the activities SC under climate warming. Our results show there been no significant changes frequency and duration these TCs, but their intensities unexpectedly decreased by ∼20% since 1980, which inconsistent with previous change increases TC intensity. The consistently a decrease different...
Background The best anesthetic management strategy for patients with acute large vessel occlusion treated mechanical thrombectomy (MT) remains uncertain. Most studies have focused on anterior–circulation stroke caused by artery occlusion. Nevertheless, limited data are available the appropriate choice of basilar (BAO). We aimed to investigate effect method clinical outcomes in BAO undergoing MT. Methods Patients MT BASILAR registry (Acute Basilar Artery Occlusion Study) were included....
OBJECTIVE First-pass effect (FPE), defined as successful reperfusion (modified Thrombolysis in Cerebral Infarction score 2b–3) with a single stent retriever attempt without salvage treatment, has not been fully identified patients acute basilar artery occlusion (BAO). The authors’ aim was to assess the impact of FPE on efficacy and safety for BAO. METHODS authors included data from Acute Basilar Artery Occlusion Study (BASILAR) about who underwent mechanical thrombectomy within 24 hours...
To date, few data have been reported on clinical outcomes following interventions in elderly populations with acute basilar artery occlusion. Using from the Endovascular Treatment for Acute Basilar Artery Occlusion Study (BASILAR), we evaluated efficacy and safety of intervention determined predictors among patients China.Patients January 2014 to May 2019 were dichotomized into (75 years or older) nonelderly (under 75 years). Pearson's Chi-square test multivariate logistic regression...
<b><i>Introduction:</i></b> The aim of this study was to test the hypothesis that intravenous tirofiban improves functional outcomes without promoting risk intracranial hemorrhage (ICH) in stroke secondary basilar artery occlusion (BAO) receiving endovascular thrombectomy. <b><i>Methods:</i></b> Patients with acute BAO who were treated thrombectomy and had treatment information derived from “BASILAR”: a nationwide, prospective registry. All...
IgA nephropathy (IgAN) is one of the most common forms chronic glomerulonephritis, but aetiology and pathogenesis remain unclear. Cuproptosis a newly identified form cell death that plays an important role in many diseases. Researchers have not clearly determined whether expression cuproptosis-related genes (CRGs) involved IgAN.The GSE93798, GSE50469 GSE37460 datasets containing microarray data from patients with IgAN (63) healthy controls (31) were downloaded GEO database. Immune cells...
Eight randomized controlled trials have consistently shown that endovascular treatment plus best medical improves outcome after acute anterior proximal intracranial large vessel occlusion strokes. Whether intravenous thrombolysis prior to in patients with circulation, is of any additional benefits remains unclear.This study compares the safety and efficacy direct versus recombinant tissue-type plasminogen activator bridging (bridging therapy) stroke internal carotid artery or middle cerebral...
Authors of this study aimed to investigate the efficacy and safety endovascular treatment (EVT) versus standard medical (SMT) alone in patients with acute basilar artery occlusion (BAO) moderate deficit (National Institutes Health Stroke Scale [NIHSS] score 10-19).
Objective The aim of this study was to evaluate the effectiveness and safety rescue therapy, a therapy in which devices such as balloon angioplasty, Apollo stent, Wingspan Solitaire or other self-expanding stents are used after failure mechanical thrombectomy (MT) determine most effective measure for acute basilar artery occlusion (BAO) MT. Methods For study, we recruited patients from BASILAR registry. All participants were divided into three groups: recanalized with group, without...
Background and Purpose: The BASILAR registry, a nationwide prospective nonrandomized study conducted in China, enrolled consecutive patients with acute basilar artery occlusion receiving endovascular treatment or conventional-treatment from January 2014 to May 2019. This article aimed report the results of clinical follow-up at one year among these patients. Methods: primary outcome was modified Rankin Scale year, assessed as common odds ratio using ordinal logistic regression analysis...
Abstract Aims The purpose of this retrospective propensity score‐matched study was to evaluate the superiority different application approaches [continuous diuretics use (CDU) vs. intermittent (IDU)] and types [loop (LDs) thiazide (TDs)] on long‐term outcomes for rheumatic heart disease (RHD) patients with compensated chronic failure (CHF). Methods results A total 494 RHD CHF were analysed after score matching. Cox proportional hazards regression model used investigate associations diuretic...
Background: As a glycoprotein IIb/IIIa receptor inhibitor, tirofiban may help reduce the risk of vascular complications during percutaneous transluminal coronary intervention. However, evidence on whether improve outcomes stroke patients with large vessel occlusion who are receiving endovascular treatment is limited. Objective: This trial aims to assess additional intravenous therapy can clinical undergo within 24 hours symptom onset. Methods and Design: The Endovascular Treatment With...
Ischemic stroke is related to inflammation. We investigated leukocyte counts, neutrophil and NLR (neutrophil-to-lymphocyte ratio) explore their prognostic potential determine if high counts before endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO) are associated worse outcomes at 90 days post-EVT.Leukocyte were determined eligible from the Acute Basilar Artery Occlusion Study (BASILAR). Patients divided into four groups according quartiles. The primary outcome...
Abstract Aims Rheumatic heart disease (RHD) remains a major global health problem. Renin–angiotensin–aldosterone system inhibitors (RAASi) are commonly administered in the treatment of cardiovascular disease, but its role RHD patients is still limited. We performed retrospective study to determine effect RAASi on long‐term outcomes for patients. Methods and results A 1:1 propensity score matching was implemented balance baseline characteristics between groups non‐RAASi. Cox proportional...
Background: In acute ischemic stroke patients with large vessel occlusion, the role of intravenous tirofiban or alteplase as an adjunct to endovascular treatment (EVT) is still uncertain. Methods: This post hoc analysis used data from 467 included in two multicenter, randomized clinical trials that assessed adjunctive medications thrombectomy (DEVT and RESCUE BT). Patients were treated EVT alone (EVT-alone group), plus (tirofiban+EVT (alteplase+EVT group). The primary outcome was functional...
Renal artery stenosis (RAS) is an important cause of chronic kidney disease (CKD). The main purpose this study was to explore the clinical characteristics and predictors low-grade RAS in female patients with CKD.One hundred five CKD from Huadong Hospital affiliated Fudan University who underwent 3 T non-contrast renal magnetic resonance angiography (MRA) were analyzed. Basic statistics methods used study, such as independent-sample t test,non-parametric test, binary logistic regression...
This study investigates the impact of assimilating Aircraft Meteorological Data Relay (AMDAR) observations on prediction two typhoons, Nesat and Haitang (2017), using Gridpoint Statistical Interpolation (GSI) assimilation system Weather Research Forecasting (WRF) model. Two quality control (QC) methods, Minimum Covariance Determinant (MCD) one-class Support Vector Machine (OCSVM), were employed to perform QC AMDAR before data assimilation. The results indicated that both methods...