A5001291417- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Asthma and respiratory diseases
- Ferroptosis and cancer prognosis
- Medical Imaging and Analysis
- Pelvic and Acetabular Injuries
- Wound Healing and Treatments
- Orthopaedic implants and arthroplasty
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hip and Femur Fractures
- Hepatitis B Virus Studies
- Bone fractures and treatments
- Cervical and Thoracic Myelopathy
- Bone health and osteoporosis research
- Acute Ischemic Stroke Management
- Brain Metastases and Treatment
- Bone and Joint Diseases
- Lipid metabolism and disorders
- Mesenchymal stem cell research
- Neonatal Respiratory Health Research
- Lung Cancer Research Studies
- Immune cells in cancer
- Lung Cancer Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Management of metastatic bone disease
North Sichuan Medical University
2023-2025
Changsha Central Hospital
2018-2025
University of South China
2014-2025
Hebei Medical University
2022-2024
First Affiliated Hospital of Hebei Medical University
2022-2024
Changchun University of Chinese Medicine
2016-2024
Chengdu Third People's Hospital
2023-2024
Guangdong 999 Brain Hospital
2021-2024
Zhejiang University
2024
Ministry of Agriculture and Rural Affairs
2024
Objective. Patients with severe asthma respond poorly to corticosteroids, and their care accounts for more than 60% of the total costs attributed asthma. Neutrophils form neutrophil extracellular traps (NETs), which play a crucial role in Statins have shown anti-inflammatory effects by reducing NETosis. In this study, we investigate if simvastatin can attenuate NETosis underlying mechanism. Methods. Mice were concomitantly sensitized ovalbumin (OVA), house dust mite (HDM), lipopolysaccharide...
Abstract Immunotherapy is a vital treatment for patients with cutaneous melanoma (CM), but effective predictors to guide clinical immunotherapy are lacking. Cuproptosis newly discovered mode of cell death related tumorigenesis. Exploring the relationship between cuproptosis and effect on CM could better management. We clustered all in Cancer Genome Atlas (TCGA) database based cuproptosis-related genes (CRGs). Prognosis, immunotherapeutic effect, tumor microenvironment score, expression...
The current diagnostic biomarkers of acute myocardial infarction (AMI), troponins, lack specificity and exist as false positives in other non-cardiac diseases. Previous studies revealed that cuproptosis, ferroptosis, immune infiltration are all involved the development AMI. We hypothesize combining analysis AMI will help identify more precise biomarkers. results showed a total 19 cuproptosis- ferroptosis-related genes (CFRGs) were differentially expressed between healthy groups. Functional...
The prognosis for severe asthma is poor, and the current treatment options are limited. methyl-CpG binding domain protein 2 (MBD2) participates in neutrophil-mediated through epigenetic regulation. Neutrophil extracellular traps (NETs) play a critical role pathogenesis of asthma. This study aims to detect if MBD2 can reduce NETs formation potential mechanism A model was established C57BL/6 wild-type mice exposure house dust mite (HDM), ovalbumin (OVA), lipopolysaccharide (LPS). Enzyme-linked...
Human herniated disc tissues and rat nucleus pulposus (NP) cells were used following approval by the authors' institutional Ethics Review Committee Animal Care Use Committee.To determine expression of leptin its functional receptor in tissues, to elucidate whether can stimulate NP proliferate vitro.There is evidence showing that chondrocytes express receptor, stimulates chondrocyte proliferation vitro may play a role pathogenesis osteoarthritis contributing osteophyte formation....
LINC01492 polymorphism has been implicated in the susceptibility of large artery atherosclerotic (LAA) stroke; however, a dearth systematic research exists regarding this association Asian population at present. This study enrolled Han Chinese patients with LAA stroke (n = 428) and age- sex-matched controls 434). We employed dominant, recessive, codominant genetic models to analyze distribution alleles genotypes for 14 tag single nucleotide polymorphisms (SNPs) LINC01492. Furthermore, we...
The characteristics of chicken droppings are closely linked to their health status. In prior studies, recognition is treated as an object detection task, leading challenges in labeling and missed due the diverse shapes, overlapping boundaries, dense distribution droppings. Additionally, use intelligent monitoring equipment equipped with edge devices farms can significantly reduce manual labor. However, limited computational power presents deploying real-time segmentation algorithms for field...
Dual-energy X-ray absorptiometry (DXA) is commonly used for evaluation of bone mineral density before spinal surgery, but frequently leads to overestimation in degenerative diseases due osteoproliferation factors. We introduce a novel method compare the predictive ability Hounsfield Units (HU) and DXA methods predict screw loosening after lumbar interbody fusion surgery by measuring HU pedicle trajectory on computed tomography (CT) images preoperatively.This retrospective study was conducted...
Abstract Background Large Language Models (LLMs) are increasingly being explored for medical applications, particularly in emergency triage where rapid and accurate decision-making is crucial. This study evaluates the diagnostic performance of two prominent Chinese LLMs, “Tongyi Qianwen” “Lingyi Zhihui,” alongside a newly developed model, MediGuide-14B, comparing their effectiveness with human experts chest pain triage. Methods Conducted at Peking University Third Hospital’s centers from...
This study was designed to confirm the correlation of hyperinsulinemia with ossification posterior longitudinal ligament (OPLL) cervical spine in vitro.To investigate effects insulin on proliferation, collagen synthesis, and osteogenic differentiation isolated rat spinal cell presence or absence bone morphogenetic protein-2 (BMP-2).Noninsulin-dependent diabetes mellitus is an independent risk factor for onset OPLL, but mechanism still unknown. We have hypothesized that may exert direct...
Low elastic modulus expandable pedicle screw (L-EPS) was inserted into osteoporotic sheep. Biomechanical tests, micro-CT analysis and histologic observation were performed.To find out whether the L-EPS can further improve fixation strength compared to screws (EPS) in sheep spine. The screw-bone interface is also detected by micro-computed tomography (CT) techniques.There are some studies on EPS vivo; however, no earlier study has focused of EPS, especially osteoporosis.Twelve months after...