Pieter J. Hoekstra
A5039838663- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Geophysical and Geoelectrical Methods
- Bipolar Disorder and Treatment
- Geophysical Methods and Applications
- Eating Disorders and Behaviors
- Child Nutrition and Feeding Issues
- Family and Disability Support Research
- Adolescent and Pediatric Healthcare
- Down syndrome and intellectual disability research
- Children's Physical and Motor Development
- Genetics and Neurodevelopmental Disorders
- Climate change and permafrost
- Schizophrenia research and treatment
- Pharmaceutical studies and practices
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Maternal Mental Health During Pregnancy and Postpartum
- Behavioral and Psychological Studies
- Genetic Associations and Epidemiology
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
Accare
2009-2025
Vrije Universiteit Amsterdam
2024
Feinstein Institute for Medical Research
2023
Tel Aviv University
2021-2022
University of Calgary
2021-2022
University College London
2021-2022
Schneider Children's Medical Center
2021
Dialyse Centrum Groningen
2003-2021
To develop a European guideline on pharmacologic treatment of Tourette syndrome (TS) the available literature was thoroughly screened and extensively discussed by working group Society for Study (ESSTS). Although there are many more studies pharmacotherapy TS than behavioral options, only limited number meets rigorous quality criteria. Therefore, we have devised two-stage approach. First, present highest level evidence reporting findings existing Cochrane reviews in this field. Subsequently,...
Tourette's syndrome is a common developmental neuropsychiatric disorder characterized by chronic motor and vocal tics. Despite strong genetic contribution, inheritance complex, risk alleles have proven difficult to identify. Here, we describe an analysis of linkage in two-generation pedigree leading the identification rare functional mutation HDC gene encoding L-histidine decarboxylase, rate-limiting enzyme histamine biosynthesis. Our findings, together with previously published data from...
Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder. It has been linked to reductions in total brain volume and subcortical abnormalities. However, owing heterogeneity within between studies limited sample sizes, findings on the neuroanatomical substrates of ADHD have shown considerable variability. Moreover, it remains unclear whether alterations are also present unaffected siblings those with ADHD.To examine whole-brain volumes study familial...
We investigated antipsychotic drug prescription practice of Dutch ID physicians, studying prevalence use, reasons for and the relationship between these patient characteristics.A cross-sectional study medical pharmaceutical records in a population living residential settings three care providers persons with IDs Netherlands (n = 2373).Prevalence use was 32.2% (95% CI 30.1-33.9). Behavioural problems were reason drugs 58% cases psychotic disorder or symptoms 22.5%. In 11.7% diagnosis...
Highlights•Recurrent de novo variants identify a new high-confidence TD risk gene: CELSR3•Genes involved in cell polarity are more likely to be disrupted by variants•De sequence may carry simplex families, female probands•De CNVs occur 2 3 times often probands than matched controlsSummaryWe previously established the contribution of damaging Tourette disorder (TD) through whole-exome sequencing 511 trios. Here, we an additional 291 trios and analyze combined set 802 We observe...
There are very few studies on the long-term outcome of children and adolescents with ADHD-combined type in Europe. The objective present study is to assess 6-year (including pharmacological treatment) a large cohort participants (N = 347, mean age 11.4 years) late adolescence early adulthood. At entry follow-up (mean 17.4 years), were comprehensively assessed ADHD comorbid disorders by structured psychiatric interviews multi-informant questionnaires. Overall functioning was Children’s Global...
Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex the ASD phenotype ADI-R (376 females, 1763 males) and ADOS (233 1187 males). On ADI-R, early childhood restricted repetitive behaviours were lower females than males, alongside comparable levels of social interaction communication difficulties males. Current scores showed no for severity. There...
Dysfunctional response inhibition is a key executive function impairment in attention deficit hyperactivity disorder (ADHD). Still, behavioral measures do not consistently differentiate affected from unaffected individuals. The authors therefore investigated neural correlates of and the familial nature these correlates.Functional MRI measurements activation during stop-signal task were obtained adolescents young adults with ADHD (N=185), their siblings (N=111), healthy comparison subjects...