A5100689175- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Pancreatic function and diabetes
- Advanced biosensing and bioanalysis techniques
- Wound Healing and Treatments
- Medical Imaging and Pathology Studies
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- CAR-T cell therapy research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Bone and Joint Diseases
- Dialysis and Renal Disease Management
- Immunotherapy and Immune Responses
- Adipose Tissue and Metabolism
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2021-2025
Hainan Medical University
2018-2025
Fujian Medical University
2013-2025
Wenzhou Medical University
2014-2025
Soochow University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Capital Medical University
2019-2024
BGI Research
2024
University of Electronic Science and Technology of China
2017-2024
Deyang Stomatological Hospital
2024
<h3>Context</h3>Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain challenging. Reportedly, mesenchymal stem cells (MSCs) have successfully treated graft-vs-host disease.<h3>Objective</h3>To assess autologous MSCs as replacement of antibody for patients with end-stage renal disease who undergo ABO-compatible, cross-match–negative transplants from a living-related...
Dicer is an enzyme that generates microRNA (miRNA), which are small, noncoding RNA function as important regulators of gene and protein expression. For exploration the functional roles miRNA in glomerular biology, was inactivated selectively mouse podocytes. Mutant mice developed proteinuria 4 to 5 weeks after birth died several later, presumably from kidney failure. Multiple abnormalities were observed glomeruli mutant mice, including foot process effacement, irregular split areas basement...
Abstract Background Hypoxia is a major cause of beta cell death and dysfunction after transplantation. The aim this study was to investigate the effect exosomes derived from mesenchymal stem cells (MSCs) on under hypoxic conditions potential underlying mechanisms. Methods Exosomes were isolated conditioned medium human umbilical cord MSCs identified by WB, NTA, transmission electron microscopy. Beta (βTC-6) cultured in serum-free presence or absence 2% oxygen conditions. Cell viability...
Pancreatic ductal adenocarcinoma (PDAC) shows a remarkable predilection for liver metastasis. Pro-oncogenic secretome delivery and trafficking via exosomes are crucial pre-metastatic microenvironment formation This study aimed to explore the underlying mechanisms of how PDAC-derived (Pex) modulate promote metastasis.C57BL/6 mice were 'educated' by tail vein Pex injection. The intrasplenic injection metastasis PDAC orthotopic transplantation models used evaluate Stable cell lines CD44v6 (CD44...
The main limit of hydrogel used as an independent wound dressing is its poor water retention, brittleness, and weak skin adhesion. Focusing on it, the macromolecular cross-linked chitosan polyacrylamide double network (C-A) chosen a functional layer, another robust poly(vinyl alcohol)-polyacrylamide/glycerin (P-A) protective layer designed to cover surface, interfacial reaction happens link two layers tightly for achieving function synergy. In this double-layer (DH) dressing, surface P-A...
Extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (MSCs) pretreated with atorvastatin (ATV) (MSC
OBJECTIVE To determine the safety and effects on insulin secretion of umbilical cord (UC) mesenchymal stromal cells (MSCs) plus autologous bone marrow mononuclear cell (aBM-MNC) stem transplantation (SCT) without immunotherapy in established type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS Between January 2009 December 2010, 42 patients with T1D were randomized (n = 21/group) to either SCT (1.1 × 106/kg UC-MSC, 106.8 aBM-MNC through supraselective pancreatic artery cannulation) or standard...
Modulation of nitric oxide (NO) on ion homeostasis, by enhancing salt secretion in the glands and Na+ sequestration into vacuoles, was investigated a salt-secreting mangrove tree, Avicennia marina (Forsk.) Vierh. The major results are as follows: (i) under 400 mM NaCl treatment, application 100 µM sodium nitroprusside (SNP), an NO donor, significantly increased density crystals rate leaves, along with maintaining low to K+ ratio leaves. (ii) measurement element contents X-ray microanalysis...
Significance The current widespread exposure of humans to natural as well man-made nanomaterials due the deployment nanoparticles (NPs) food additives, vaccine- or drug-delivery vehicles, and in diagnostic procedures encourages evaluation their interaction with innate immune system. Understanding how organisms cope hydrophobic chemically inert particulate matter, which is excluded from metabolic processing, major importance for interpreting responses associated use NPs biosphere. containment...
The real-time health monitoring system is a promising body area network application to enhance the safety of firefighters when they are working in harsh and dangerous environments. Other than physiological status firefighters, on-body networks can be also regarded as candidate solution motion detection classification. In this paper, we consider classification with features obtained from radio frequency (RF) channel. Various relevant RF have been identified support vector machine (SVM) has...
Abstract Background Bone marrow mesenchymal stem cells (MSCs) are among the most common cell types to be used and studied for cardiac regeneration. Low survival rate difficult retention of delivered MSCs in infarcted heart remain as major challenges field. Co-delivery cell-derived exosomes (Exo) is expected improve recruitment transplanted MSCs. Methods Exo was isolated from an acute myocardial infarction (AMI) rat through intramyocardial injection with or without intravenous infusion...
C/EBP-homologous protein (CHOP) is an important component of the endoplasmic reticulum (ER) stress response. We demonstrated induction ER in response to tunicamycin stimulation, as evidenced by increased expression chaperone proteins Grp78, Grp94, and enhanced eukaryotic initiation factor 2 subunit 1 (eIF2α) phosphorylation hepatocellular carcinoma cells. Tunicamycin-induced resulted apoptosis autophagy simultaneously. While inhibition mediated 3-methyladenine pretreatment or direct...
Characterization of the thermal properties surface and subsurface structures skin can reveal degree hydration, rate blood flow in near‐surface micro‐ macrovasculature, other important physiological information relevance to dermatological overall health status. Here, a soft, stretchable sensor, based on so‐called three omega (i.e., 3ω) method, is introduced for accurate characterization conductivity diffusivity materials systems, such as skin, which be challenging measure using established...
Abstract Background Bone marrow cells (BMCs), especially mesenchymal stem (MSCs), have shown attractive application prospects in acute myocardial infarction (AMI). However, the weak efficacy becomes their main limitation clinical translation. Based on anti-inflammation and anti-apoptosis effects of a Chinese medicine-Tongxinluo (TXL), we aimed to explore TXL-pretreated MSCs (MSCs TXL ) enhancing cardiac repair further investigated underlying mechanism. Methods or derived exosomes -exo...
The real-time health monitoring system is a promising body area network application to enhance the safety of fire fighters when they are working in harsh and dangerous environment. Except for physiological status fighters, on-body can be also regarded as candidate solution motion detection classification. In this paper, novel Support Vector Machine (SVM) classifier has been implemented using RF signals classification features. capable detecting classifying seven frequently appeared motions...
B‐cell‐specific Moloney murine leukemia virus insertion site 1 (BMI1) is a member of the polycomb group transcriptional repressors. Until now, its expression and functional significance in pancreatic carcinogenesis was unknown. In present study, we demonstrated that BMI1 markedly up‐regulated cancer cell lines surgically resected specimens. addition, levels correlated positively with presence lymph node metastases negatively patient survival rates, suggesting role for progression cancer....
The biggest victim of ambient air pollution is the respiratory system. Mainly because harmful components, especially particulate matters with an aerodynamic diameter ≤ 2.5µm (PM2.5), can be directly inhaled and deeply penetrate into lung alveoli, thus causing severe dysfunction, including chronic cough, bronchitis asthma, even cancer. Unfortunately, toxicological mechanisms PM2.5 associations these adverse outcomes have still not been clearly unveiled. Here, we found that rapidly induced...
<h3>BACKGROUND:</h3> Elevated dead space fraction (the ratio of to tidal volume [V<sub>D</sub>/V<sub>T</sub>]) is a feature ARDS. PEEP can partially reverse atelectasis, prevent alveoli recollapse, and improve lung compliance gas exchange in patients with However, whether V<sub>D</sub>/V<sub>T</sub> variables have close relationship collapse alveolar recruitment remains under recognized. Meanwhile, few clinicians titrate consideration changes V<sub>D</sub>/V<sub>T</sub>. Therefore, we...
Skin cancer is the most common in United States, and ultraviolet B (UVB) radiation-induced DNA damage major environmental factor underlying skin development. p21, a p53-inducible protein, plays key role cellular response to UVB-induced damage.Through p21 silencing overexpression, we investigated of apoptosis, proliferation, cell cycle arrest, oxidative stress UVB-irradiated HaCaT keratinocytes.We found that UVB exposure induced significant downregulation (p<0.05) was associated with...
We investigated whether and how recipient-donor sex affects transplantation outcomes of 11,797 patients transplanted between 2008 2010. Thirty-seven percent were male recipients with donors, 21% female 25% 17% donors. In multivariable analyses, had inferior overall survival progression-free compared to females regardless donor sex, an 11% relative increase in the hazard death (P