A5035746917- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Genetic Associations and Epidemiology
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- Venous Thromboembolism Diagnosis and Management
- Cardiac Fibrosis and Remodeling
- Obesity, Physical Activity, Diet
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Eating Disorders and Behaviors
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Aortic aneurysm repair treatments
- Cardiac electrophysiology and arrhythmias
- Behavioral Health and Interventions
- Tissue Engineering and Regenerative Medicine
- Health disparities and outcomes
- Metabolomics and Mass Spectrometry Studies
- Gestational Diabetes Research and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Fu Wai Hospital
2021-2024
Capital Medical University
2023-2024
Peking Union Medical College Hospital
2023
State Key Laboratory of Cardiovascular Disease
2021-2022
E Ink (South Korea)
2022
Institute of Soil Science
2022
Chinese Academy of Sciences
2022
University of Chinese Academy of Sciences
2022
Lanzhou University
2017
Extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (MSCs) pretreated with atorvastatin (ATV) (MSC
Background: Exosomes derived from bone marrow mesenchymal stem cells (MSC-exo) have been considered as a promising cell-free therapeutic strategy for ischemic heart disease. Cardioprotective drug pretreatment could be an effective approach to improve the efficacy of MSC-exo. Nicorandil has long used in clinical practice cardioprotection. This study aimed investigate whether effects exosomes nicorandil pretreated MSC (MSC NIC -exo) enhanced facilitating cardiac repair after acute myocardial...
Abstract Background Bone marrow cells (BMCs), especially mesenchymal stem (MSCs), have shown attractive application prospects in acute myocardial infarction (AMI). However, the weak efficacy becomes their main limitation clinical translation. Based on anti-inflammation and anti-apoptosis effects of a Chinese medicine-Tongxinluo (TXL), we aimed to explore TXL-pretreated MSCs (MSCs TXL ) enhancing cardiac repair further investigated underlying mechanism. Methods or derived exosomes -exo...
A growing number of cohort studies revealed an inverse association between cheese intake and cardiovascular diseases, yet the causal relationship is unclear.To assess intake, diseases biomarkers.A two-sample Mendelian randomization (MR) analysis based on publicly available genome-wide was employed to infer relationship. The effect estimates were calculated using random-effects inverse-variance-weighted method.Cheese per standard deviation increase causally reduced risks type 2 diabetes (odds...
Background: Previous observational studies provided conflicting results on the association between low-density lipoprotein cholesterol (LDL-C) level and risk of Alzheimer's disease (AD). Objective: We used two-sample Mendelian randomization (MR) study to explore causal associations LDL-C risks individual, paternal, maternal, family history AD. Methods: Summary-level genetic data for were acquired from UK Biobank GWAS. Corresponding AD obtained NHGRI-EBI Catalog human genome-wide studies....
Abstract Background Although some studies have indicated that Psoriasis could contribute to the risk of idiopathic pulmonary fibrosis (IPF), no study has reported a clear causal association between them. Our aim was explore potential relationship and IPF using Mendelian randomization (MR) design. Methods To IPF, we used genetic instruments from largest available genome-wide (GWAS) European ancestry, including psoriasis (5314 cases, 457,619 controls) (1028 196,986 controls). main analyses...
Background Diabetes was considered as a risk factor for venous thromboembolism (VTE), but conflicting findings have been reported from observational studies. This study aimed at investigating the causal associations of type 1 and 2 diabetes with VTE, including deep vein thrombosis (DVT) pulmonary embolism (PE). Methods We designed bidirectional two-sample Mendelian randomization (MR) analysis by using summary-level data large genome-wide association studies performed in European individuals....
Abstract Background Previous observational studies indicated that atrial fibrillation may increase the risk of breast cancer. Following a cancer diagnosis, chance developing as well. However, it is uncertain whether link causal or just due to confounding factors. Objective Using bidirectional Mendelian randomization (MR) analysis, we sought assess relationship between and from genetic level. Methods Large genome‐wide association yielded summary‐level data for The preliminary estimate was...
Conflicting evidence still exists regarding Vitamin B12's involvement in coronary heart disease (CHD). There is no precedent for previous studies to include both B12, B6, as well E the consideration of CHD associating factors. Our data derived from National Health and Nutrition Examination Survey (NHANES), which covers period 2003-2020. 33,640 samples were included this cross-sectional study. We used an unadjusted covariates three adjusted covariates. The intake percentage Vitamins E, B12...
Histone ubiquitination regulates sperm formation and is important for nucleosome removal during spermatogenesis. RNF8 an E3 ubiquitin ligase, RAD6B E2 ubiquitin-conjugating enzyme. Both proteins participate in DNA damage repair processes via histone ubiquitination. Loss of or can lead to sterility male mice. However, the specific mechanisms regulating these ubiquitin-mediated are unclear. In this study, we found that knockout mice were either subfertile sterile based on numbers offspring...
Objective: Observational studies showed that Type 2 diabetes increased the risk of breast cancer, and vice versa. However, it is uncertain whether link causal or just due to confounding factors. Using bidirectional Mendelian randomization analysis, we assessed relationship from a genetic level. Methods: Large genome-wide association yielded summary-level data for cancer. Results: Genetically predicted presented no statistically significant with overall cancer its subtypes. Similarly,...
Aim: To determine the efficacy and safety of intracoronary infusion autologous bone marrow mesenchymal stem cells (MSCINJ) in combination with intensive atorvastatin (ATV) treatment for patients anterior ST-segment elevation myocardial infarction-elevation infarction. Patients & methods: The trial enrolls a total 100 ST-elevation subjects are randomly assigned (1:1:1:1) to receive routine ATV (20 mg/d) placebo or MSCsINJ (80 MSCsINJ. primary end point is absolute change left ventricular...
Several observational studies indicated that atrial fibrillation might aggravate other cardiovascular diseases apart from ischaemic stroke. However, it remains to be determined whether these associations reveal independent causation. Using Mendelian randomization (MR), we systematically investigated how genetically predicted affected and cardiac death.Summary-level data for were obtained public genome-wide association study data. The random inverse-variance weighted method was treated as the...
To investigate the prevalence and outcomes of primary percutaneous coronary intervention (PCI) in Chinese patients with ST-segment elevation myocardial infarction (STEMI) aged ≥75 years.
As the predominant leisure-time sedentary behavior, television viewing was documented to increase cardiovascular diseases in observational studies, yet causal relationship and potential mechanisms remain be determined.
Abstract Background: As the predominant leisure-time sedentary behavior, television viewing was documented to increase cardiovascular diseases in observational studies, yet causal relationship and potential mechanisms remain be determined. Objectives: To systematically investigate between time, diseases, mechanisms. Methods: We conducted a two-sample Mendelian randomization (MR) analysis estimate associations with biomarkers of cardiometabolic risk. The random inverse-variance weighted...