A5035437162- Radiation Detection and Scintillator Technologies
- Thyroid Disorders and Treatments
- Gamma-ray bursts and supernovae
- Parkinson's Disease Mechanisms and Treatments
- Particle Detector Development and Performance
- Nuclear Physics and Applications
- Astrophysics and Cosmic Phenomena
- Medical Imaging Techniques and Applications
- Growth Hormone and Insulin-like Growth Factors
- Nuclear Receptors and Signaling
- Astrophysical Phenomena and Observations
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Advanced X-ray and CT Imaging
- Astronomical Observations and Instrumentation
- Estrogen and related hormone effects
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- Neurological diseases and metabolism
- Hormonal and reproductive studies
- Astronomy and Astrophysical Research
- Neurological disorders and treatments
- Radiation Dose and Imaging
- Effects and risks of endocrine disrupting chemicals
- Genetic Neurodegenerative Diseases
University of Birmingham
2015-2024
University of KwaZulu-Natal
2022
Edendale Hospital
2022
University of Hong Kong
1999-2010
Queen Mary Hospital
1999-2010
Symetrica Security (United Kingdom)
2005-2009
Queen Elizabeth Hospital Birmingham
1997-2007
University of Southampton
1991-2005
Nokia (United States)
2003
AT&T (United States)
2002
Parkinson disease (PD) is an age-related neurodegenerative disorder associated with misfolded SNCA/α-synuclein accumulation in brain. Impaired catabolism of SNCA potentiates formation its toxic oligomers. LRRK2 (leucine-rich repeat kinase-2) mutations predispose to familial and sporadic PD. Mutant perturbs chaperone-mediated-autophagy (CMA) degrade SNCA. We showed greater age-dependent oligomeric striatum cortex aged LRRK2R1441G knockin (KI) mice, compared age-matched wildtype (WT) by 53%...
Catechol-<i>O</i>-methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme that crucial to the metabolism of carcinogenic catechols and catecholamines. Regulation human COMT gene expression may be important in pathophysiology various disorders including estrogen-induced cancers, Parkinson's disease, depression, hypertension. The gender difference activity variations rat during estrous cycle led us explore whether estrogen can regulate transcription. Our Northern analyses showed...
Uncoupling proteins (UCPs) belong to a large family of mitochondrial solute carriers 25 (SLC25s) localized at the inner membrane. UCPs transport protons directly from intermembrane space matrix. Of five structural homologues (UCP1 5), UCP4 and 5 are principally expressed in central nervous system (CNS). Neurons derived their energy form ATP that is generated through oxidative phosphorylation carried out by multiprotein complexes (Complexes I-V) embedded In phosphorylation, flow electrons...
Mitochondrial dysfunction causes energy deficiency and nigrostriatal neurodegeneration which is integral to the pathogenesis of Parkinson disease (PD). Clearance defective mitochondria involves fission ubiquitin-dependent degradation via mitophagy maintain homeostasis. We hypothesize that LRRK2 (leucine-rich repeat kinase 2) mutation disrupts mitochondrial turnover causing accumulation in aging brain. found more ubiquitinated with aberrant morphology associated impaired function aged (but...
Reports that bacteria within the Firmicutes phylum, especially species Faecalibacterium prausnitzii, are less abundant in Crohn's disease (CD) patients and supernatants from cultures of this bacterium anti-inflammatory prompted investigation possible correlations between abundance F. prausnitzii response to treatment with gut diseases healthy controls. In a randomized, double-blind trial, faeces were collected volunteers, active CD, ulcerative colitis (UC) irritable bowel syndrome before...
BackgroundThe aim of this study was to determine whether volatile organic compounds (VOCs) present in the headspace feces could be used diagnose or distinguish between chronic diseases gastrointestinal tract and apparently healthy volunteers.
This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in converging pathogenic processes involved Parkinson's disease (PD). Mitochondria provide cellular energy form ATP via phosphorylation, but as an integral part this process, superoxides other reactive oxygen species are also produced. Excessive free radical production contributes to stress. Cells have evolved handle such various endogenous anti-oxidant proteins. One family proteins is...
<b><i>Objective:</i></b> To determine whether reported genetic association of polymorphisms in the <i>CYP2D6, CYP1A1, N</i>-acetyltransferase 2<i> (NAT2), DAT1,</i> and glutathione s-transferase M1 <i>(GSTM1)</i> genes with PD were evident a population 176 unrelated patients sporadic to extend these findings other disease groups (familial [n = 30], ALS 50], multiple system atrophy 38], progressive supranuclear palsy 35], AD 23]). <b><i>Methods:</i></b> A combination allele-specific PCR...
A stereotactic radiosurgery unit was commissioned in Weston Park Hospital the summer of 1985. This paper describes design, principles operation and safety features multiple-beam cobalt-60 therapy unit. The measurement dose around extremely sharp focus produced by 201 beams is discussed results compared with computed distributions. radiation protection survey are presented design purpose-built treatment suite discussed. procedure for a patient outlined.
SUMMARY In clinically euthyroid subjects on long‐term amiodarone therapy free thyroxine (T4) concentrations were increased and triiodothyronine (T3) levels reduced. There was also a marked increase in reverse T3 the treated group. These changes are consistent with inhibition of peripheral deiodination T4 T3. Despite rise serum thyrotrophin (TSH) increased, suggesting an effect anterior pituitary. To investigate interaction cellular actions thyroid hormones we examined influence drug vitro...
The effects of surgical stress on the metabolism retinol-binding-protein-thyroxine-binding-prealbumin complex were investigated. immediate postsurgical period was characterized by a rapid decline in serum concentration retinol, retinol binding protein and triiodothyronine an increase 24 h urinary excretion retinol-binding-protein thyroxine. Similar, but less pronounced, changes seen other subjects suffering acute myocardial infarction not observed normal healthy euthyroid males or...
1. Subjects followed serially after acute myocardial infarction demonstrated a rapid and sustained fall in serum total tri-iodothyronine (T3) concentration rise reverse (rT3) concentration. There was transient thyroxine (T4) 2. Thyroxine binding globulin (TBG) levels were unchanged but prolonged falls observed prealbumin (TBPA) albumin concentrations. 3. In contrast to the T4, both measured calculated free T4 concentrations T3 fell as did T3. 4. Despite T3, basal thyrotrophin (TSH) not rise....
The relative abundance of different groups sulphate-reducing bacteria (SRB) in faecal DNA collected before and after therapy from patients suffering Crohn's disease (CD), irritable bowel syndrome (IBS) or ulcerative colitis (UC) has been compared with that healthy controls. Growth tests revealed SRB were not more abundant samples CD treatment than the control group. For most 128 available, these preliminary results confirmed using degenerate PCR primers amplify dsrAB gene. However, some...
In a series of experiments during 1964 small quantities radioiodine were given to nine volunteers and their thyroid uptakes urinary excretion patterns studied. The effects varying doses stable iodine on these investigated. Models the metabolism slightly amplified give satisfactory explanations experimental results. minimum amount needed block uptake completely was about 30 mg. Thyroid ceased within half an hour taking blocking dose back normal 8 days after intake. Repeated may be at...
Abstract Aging, genetics and environmental toxicity are important etiological factors in Parkinson’s disease (PD). However, its pathogenesis remains unclear. A major obstacle is the lack of an appropriate experimental model which incorporates genetic susceptibility, aging prolonged toxicity. Here, we explored interplay amongst these using mutant LRRK2 R1441G (leucine-rich-repeat-kinase-2) knockin mice. We found that primary cortical mesencephalic dopaminergic neurons were more susceptible to...
Abstract A single‐stranded conformational polymorphism in the monoamine oxidase B gene was shown to be or G, 36 bases upstream from intron 13‐exon 14 boundary. An allelic association study revealed no statistically significant associations between this single‐base and Parkinson's disease, unlike results of a previous study.