A5101874956- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Synthetic Organic Chemistry Methods
- Liver Disease Diagnosis and Treatment
- Synthesis and Biological Activity
- Plant-derived Lignans Synthesis and Bioactivity
- Traditional Chinese Medicine Analysis
- Liver physiology and pathology
- Pharmacological Effects of Natural Compounds
- Berberine and alkaloids research
- Diet, Metabolism, and Disease
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Mesenchymal stem cell research
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Studies
- Diet and metabolism studies
- Chemical Synthesis and Analysis
- Neuroscience and Neuropharmacology Research
- Planarian Biology and Electrostimulation
- Phytoestrogen effects and research
- Bioactive natural compounds
- Biochemical effects in animals
- 3D Printing in Biomedical Research
- HIV/AIDS drug development and treatment
Southwest Jiaotong University
2013-2025
Jilin Agricultural University
2025
Chengdu University of Traditional Chinese Medicine
2025
Shandong First Medical University
2024
Chongqing Medical University
2013-2023
Chongqing Medical and Pharmaceutical College
2021-2022
Arizona State University
1994-2016
Tempe Union High School District
2014
National Cancer Institute
2002-2008
Queensland Museum
2008
The northern highbush blueberry variety ‘Duke’ was used as the test material, and different concentrations of 2,4-Epibrassinolide (EBR) (0, 0.2, 0.4, 0.6, 0.8 mg·L -1 ) were applied during bud expansion stage, with a second application administered at one-day intervals following first. Samples collected bud, flower, fruit stages subsequently treated artificial low temperatures (2°C) after sampling. effects various exogenous EBR on physiological indices cold resistance expression gene VcCBF3...
Abstract This study was aimed at assessing the potential use of emulsion electrospinning to prepare core‐shell structured ultrafine fibers as carriers for therapeutic proteins. It focused on effect fiber structure release profiles and structural stability encapsulated In case bovine serum albumin (BSA) which selected a model protein, poly‐ DL ‐lactide prepared by using lower volume ratio aqueous organic phase, showed higher integrity assessed laser confocal scanning microscope (LCSM)....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT: Isolation and structure of halistatin 1 from the eastern Indian Ocean marine sponge Phakellia carteriGeorge R. Pettit, Rui Tan, Feng Gao, Michael D. Williams, Dennis L. Doubek, Boyd, Jean M. Schmidt, Charles Chapuis, Ernest Hamel, Cite this: J. Org. Chem. 1993, 58, 9, 2538–2543Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue April...
A new depside of D-(+)-beta-(3,4-dihydroxyphenyl)-lactic acid and 2-(3,4-dihydroxyphenylethenyl)-caffeic acid, named salvianolic A, was isolated from the dried roots SALVIA MILTIORRHIZA Bunge. Its chemical structure defined by spectral analysis degradation.
Accumulating evidence suggests that dysregulation of the intestinal flora potentially contributes to occurrence and development nonalcoholic fatty liver disease (NAFLD). Phyllanthus emblica (PE), an edible medicinal natural resource, exerts excellent effects on ameliorating NAFLD, but potential mechanism remains unclear. In present study, a mouse NAFLD model was established by administering choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD). The protective aqueous extract PE...
Electrical stimulation (ES) has a remarkable capacity to regulate neuronal differentiation and neurogenesis in the treatment of various neurological diseases. However, wired devices connected stimulating electrode mechanical mismatch between conventional rigid electrodes soft tissues restrict their motion cause possible infections, thereby limiting clinical utility. An approach integrating advantages wireless techniques hydrogels provides new insights into ES-induced nerve regeneration....
Background Abnormalities in brain activity patterns during episodic memory tasks have been inconsistently reported amnestic mild cognitive impairment (aMCI) patients using functional magnetic resonance imaging (fMRI). This study applied traditional Chinese medicine (TCM) syndrome differentiation to categorize aMCI into distinct subgroups, aiming clarify the neural mechanisms underlying their profiles. Methods Participants included categorized turbid phlegm clouding orifices (PCO) or...
Liver fibrosis is a pathological variation caused by almost all chronic liver injuries. As an edible and medicinal natural resource, Phyllanthus emblica (PE) has been reported to possess hepatoprotective, antioxidant, anti-inflammatory activities may have ameliorating effect on hepatic fibrosis. To investigate the protective of aqueous extract PE (AEPE) against uncover its related mechanisms, chemical profile AEPE was characterized high performance liquid chromatography (HPLC) sulfuric...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntineoplastic Agents. 277. Isolation and Structure of Phakellistatin 3 Isophakellistatin from a Republic Comoros Marine SpongeGeorge R. Pettit, Rui Tan, Delbert L. Herald, Michael D. Williams, Ronald CernyCite this: J. Org. Chem. 1994, 59, 7, 1593–1595Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April...
Bioassay-guided fractionation of extracts various plants, marine organisms, and microorganisms has led to the discovery new natural sources a number known compounds that have significant biological activity. The isolation interesting valuable cancer cell growth inhibitors including majusculamide C (1), axinastatin 5 (5), bengazoles A (6), B (7), E (8), manzamine (10), jaspamide (11), neoechinulin (19) been summarized.
Many neurons undergo apoptosis after ischemic stroke. In the brain, neurogenesis has potential for neuronal replacement and can be activated by external conditions to repair injury. Crocetin (CRO), naturally extracted from plant saffron, acts as a neuroprotective agent However, underlying mechanism remains unknown. this work, effect of CRO on neural stem cell (NSC) behaviors subventricular zone is investigated. Initially, NSCs are incubated with different concentrations detect proliferation...
Continued investigation of murine leukemia (P-388) active fractions from the African marine worm Cephalodiscus gilchristi has resulted in discovery cephalostatins 18 (1b) and 19 (1c). The structures were determined by interpretation their highfield (500 MHz) 1H, 13C, 2D NMR HRMS. Both these new methoxy steroidal alkaloids exhibited strong activity against P-388 lymphocytic cell line (ED50 ca. 10-3 μg/mL), a mini panel human cancer lines (GI50 <10-3 U.S. National Cancer Institute's 60 (mean...
Cytotoxic constituents of the terrestrial plant Bridelia ferruginea were isolated using bioactivity-guided fractionation, which revealed presence previously known deoxypodophyllotoxin (1), isopicrodeoxypodophyllotoxin (2), β-peltatin (3), β-peltatin-5-O-β-d-glucopyranoside (3a), and indole neoechinulin (4). As an extension previous podophyllotoxin research, SAR studies undertaken focused on 4-aza-podophyllotoxin structural modifications. A number such derivatives synthesized following...
The goal of this research was to evaluate the anti-hepatitis B virus (HBV) activities three compounds extracted and purified from Herpetospermum seeds (HS) on HepG2.2.15 cells. Herpetin (HPT), herpetone (HPO), herpetfluorenone (HPF) were isolated HS identified using HR-ESI-MS NMR. Different concentrations drugs added Cell toxicity observed with an MTT assay, cell culture supernatants collected, HBsAg HBeAg detected by ELISA. content HBV DNA determined via quantitative polymerase chain...
A new scalarane-type pentacyclic sesterterpene, sesterstatin 6 (6), was isolated in 8.3 x 10(-7)% yield from the Republic of Maldives marine sponge Hyrtios erecta. The structure elucidated by analyses HRMS and high-field 2-D NMR spectra. Sesterstatin showed significant cancer cell growth inhibition against murine P388 lymphocytic leukemia a series human tumor lines (ED50 0.17 microg/mL, GI50 1.8-8.9 10(-1) microg/mL) proved to be most inhibitory series.
Rhizoma coptidis , the root of Coptis chinensis Franch has been used in China as a folk medicine treatment diabetes for thousands years. Berberine, one active ingredients reported to improve symptoms and treat experimental cardiac hypertrophy, respectively. The objective this study was evaluate potential effect berberine on cardiomyocyte hypertrophy its possible influence peroxisome proliferator-activated receptor- α (PPAR )/nitric oxide (NO) signaling pathway. induced by high glucose (25.5...
Owing to the negligible or acceptable immunogenicity, small molecules capable of inducing differentiation undifferentiated stem cells into organ-specific cell types are particularly promising in developing replacement therapy, but such compounds with undescribed architectures extremely rare. Selesconol (1) is discovered from culture Daldinia eschscholzii IFB-TL01 as a skeletally unprecedented inducer for rat bone marrow mesenchymal neural cells, its unique framework clarified derive...
Ten dibenzocyclooctadiene lignans were obtained from the ethereal soluble fraction of dried roots and stems Kadsura coccinea. Two them new compounds, named kadsutherin (8) isokadsuranin (10). Their structures elucidated on basis chemical spectral analysis.
Berberine exerted anti-cancer effect in various cancer cell lines, and was also implied the treatment of metabolic related diseases. Given modulation, we hypothesized that berberine possessed under assistance interference. Working as a modulator, enzyme inhibitor or complex network regulator energy metabolism, highlighted current research. A reasonable cross talk between Chinese medicine homeostasis provided solid foundation for interference on cells reprogramming metabolism. Our result...
Parkinson's disease (PD) is a progressive neurodegenerative characterized by motor and nonmotor signs symptoms. To date, many studies of PD have focused on its cardinal study the early PD, we investigated reactions solicited heat pain stimuli in untreated patients without using fMRI. The activation patterns contact (51°C) were assessed 14 17 age- sex-matched healthy controls. Patients with showed significant decreases superior temporal gyrus (STG) insula compared In addition, relationship...