A5077319615- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Cancer Treatment and Pharmacology
- Chemical synthesis and alkaloids
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and Biological Activity
- Phytochemistry and Bioactive Compounds
- Synthetic Organic Chemistry Methods
- Plant biochemistry and biosynthesis
- Phytochemistry and Bioactivity Studies
- Biotechnology and Related Fields
- Transgenic Plants and Applications
- Synthesis of Organic Compounds
- Chemical Synthesis and Analysis
- Bioactive natural compounds
- Natural Compound Pharmacology Studies
- Organic Chemistry Cycloaddition Reactions
- Carbohydrate Chemistry and Synthesis
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Steroid Chemistry and Biochemistry
National Cancer Institute
2005-2016
Health Volunteers Overseas
2016
Office of Extramural Research
2016
Long Island University
2015
Frederick National Laboratory for Cancer Research
2001-2014
National Institutes of Health
1988-2010
University of North Carolina at Chapel Hill
2010
University of California, Irvine
2010
The University of Texas MD Anderson Cancer Center
2010
Arizona State University
1983-2008
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHIV inhibitory natural products. Part 7. The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerumYoel Kashman, Kirk R. Gustafson, Richard W. Fuller, John H. Cardellina II, James B. McMahon, Michael J. Currens, Robert Buckheit Jr., Stephen Hughes, Gordon M. Cragg, and BoydCite this: Med. Chem. 1992, 35, 15, 2735–2743Publication Date (Print):July 1, 1992Publication History...
Nature has been a source of medicinal agents for thousands years, and an impressive number modern drugs have isolated from natural sources, many based on their use in traditional medicine. In the past century, however, increasing role played by microorganisms production antibiotics other treatment some serious diseases. Advances description human genome, as well genomes pathogenic microbes parasites, is permitting determination structures proteins associated with disease processes. With...
Abstract Nature has been a source of medicinal agents for thousands years and continues to be an abundant novel chemotypes pharmacophores. With only 5 15 % the approximately 250 000 species higher plants systematically investigated, potential marine environment barely tapped, these areas will remain rich bioactive compounds. Less than 1 bacterial fungal are currently known, microbial sources, particularly those found in extreme environments, seems unbounded. To natural sources can added...
Until recently, the prevailing attitude in developed nations regarded world's genetic resources, which are mainly concentrated developing world, as a common resource of humankind, to be exploited freely irrespective national origin. With devastation being wreaked tropical rainforests and resurgence interest recent years discovery novel drugs from natural sources, particularly plants marine organisms, international scientific community has realized that conservation these global resources...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Taxol Supply Crisis. New NCI Policies for Handling the Large-Scale Production of Novel Natural Product Anticancer and Anti-HIV AgentsGordon M. Cragg, Saul A. Schepartz, Matthew Suffness, Michael R. GreverCite this: J. Nat. Prod. 1993, 56, 10, 1657–1668Publication Date (Print):October 1, 1993Publication History Published online1 July 2004Published inissue 1 October...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTaxus spp. Needles Contain Amounts of Taxol Comparable to the Bark Taxus brevifolia: Analysis and IsolationKeith M. Witherup, Sally A. Look, Michael W. Stasko, Thomas J. Ghiorzi, Gary Muschik, Gordon CraggCite this: Nat. Prod. 1990, 53, 5, 1249–1255Publication Date (Print):September 1, 1990Publication History Published online1 July 2004Published inissue 1 September...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnti-HIV Michellamines from Ancistrocladus korupensisMichael R. Boyd, Yali F. Hallock, John H. Cardellina II, Kirk P. Manfredi, W. Blunt, James B. McMahon, Robert Buckheit Jr., Gerhard Bringmann, Manuela Schäffer, Gordon M. Cragg, Duncan Thomas, and Johnson G. JatoCite this: J. Med. Chem. 1994, 37, 12, 1740–1745Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June...
The South African tree Combretumcaffrum has been shown to contain a constituent capable of significantly reversing astrocyte formation employing the National Cancer Institute's 9ASK system. responsible for reversal was isolated and designated combretastatin (1). Structural elucidation initiated spectral methods completed by X-ray crystallographic analysis. By this means assigned structure 1. Further biological evaluation total synthesis are now in progress.