A5036206395- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Synthetic Organic Chemistry Methods
- Synthesis and Biological Activity
- HIV Research and Treatment
- Traditional and Medicinal Uses of Annonaceae
- Carbohydrate Chemistry and Synthesis
- HIV/AIDS drug development and treatment
- Pharmacogenetics and Drug Metabolism
- Chemical synthesis and alkaloids
- Natural product bioactivities and synthesis
- Axial and Atropisomeric Chirality Synthesis
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Glycosylation and Glycoproteins Research
- Alkaloids: synthesis and pharmacology
- Phytochemical compounds biological activities
- Natural Compound Pharmacology Studies
- Chemical Synthesis and Analysis
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Biological Activities
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer therapeutics and mechanisms
University of Georgia
2016-2022
Vancouver Spine Surgery Institute
2021
USA Mitchell Cancer Institute
2002-2019
Temple University
2016
Vancouver General Hospital
2014
National Cancer Institute
1998-2013
Center for Cancer Research
2001-2007
University of South Alabama
2002-2007
Cancer Research Institute
1993-2007
Australian Institute of Marine Science
2007
Abstract During 1985–1990 the U.S. National Cancer Institute (NCI) phased out its murine leukemia P388 anticancer drug screening program and developed as replacement a new in vitro primary screen based upon diverse panel of human tumor cell lines. For each substance tested, generates remarkably reproducible characteristic profile differential cellular sensitivity, or lack thereof, across 60 different lines comprising panel. Several investigational approaches to display, analysis,...
The objective of this study was to develop and investigate an approach optimally detect, rank, display, analyze patterns differential growth inhibition among cultured cell lines. Such cellular responsiveness are produced by substances tested in vitro against disease-oriented panels human tumor lines a new anticancer screening model under development the National Cancer Institute. In first phase study, we developed key methodological tool, mean graph, which allowed transformation numerical...
Journal Article New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Synthetic and Natural Products AIDS-Antiviral Activity Get access Owen S. Weislow, Weislow Search other works by this author on: Oxford Academic PubMed Google Scholar Rebecca Kiser, Kiser Donald L. Fine, Fine John Bader, Bader Robert H. Shoemaker, Shoemaker Michael R. Boyd JNCI: the National Cancer Institute, Volume 81, Issue 8, 19 April 1989, Pages 577–586,...
We have isolated and sequenced a novel 11-kDa virucidal protein, named cyanovirin-N (CV-N), from cultures of the cyanobacterium (blue-green alga) Nostoc ellipsosporum. also produced CV-N recombinantly by expression corresponding DNA sequence in Escherichia coli. Low nanomolar concentrations either natural or recombinant irreversibly inactivate diverse laboratory strains primary isolates human immunodeficiency virus (HIV) type 1 as well HIV 2 simian virus. In addition, aborts cell-to-cell...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHIV inhibitory natural products. Part 7. The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerumYoel Kashman, Kirk R. Gustafson, Richard W. Fuller, John H. Cardellina II, James B. McMahon, Michael J. Currens, Robert Buckheit Jr., Stephen Hughes, Gordon M. Cragg, and BoydCite this: Med. Chem. 1992, 35, 15, 2735–2743Publication Date (Print):July 1, 1992Publication History...
Griffithsin (GRFT), a novel anti-HIV protein, was isolated from an aqueous extract of the red alga Griffithsia sp. The 121-amino acid sequence GRFT has been determined, and biologically active subsequently produced by expression corresponding DNA in Escherichia coli. Both native recombinant displayed potent antiviral activity against laboratory strains primary isolates T- M- tropic HIV-1 with EC50 values ranging 0.043 to 0.63 nm. also aborted cell-to-cell fusion transmission infection at...
The antineoplastic constituents of Combretum caffrum (Eckl. and Zeyh) Kuntze (Combretaceae family), a species indigenous to South Africa, have been investigated. Subsequently we isolated series closely related bibenzyls, stilbenes, phenanthrenes from C. caffrum. Some the stilbenes proved be potent antimitotic agents which inhibited both tubulin polymerization binding colchicine tubulin. Combretastatin A-4 has shown most cancer cell growth inhibitor series. Presently this cis-stilbene is...
Journal Article Expression of CYP1A1 Gene in Patients With Lung Cancer: Evidence for Cigarette Smoke-Induced Normal Tissue and Altered Regulation Primary Pulmonary Carcinomas Get access Theodore L. McLemore, McLemore * Program Development Research Group, Developmental Therapeutics Program, Division Cancer Treatment, National InstituteBethesda, Md † Correspondence to: M.D., 170 Eighth St. SE, Suite C, Paris, TX 75460 Search other works by this author on: Oxford Academic PubMed Google Scholar...
A recently developed tetrazolium-based microculture assay was used to screen extracts of cultured cyanobacteria (blue-green algae) for inhibition the cytopathic effects human immunodeficiency virus (HIV-1), which is implicated as a causative agent AIDS. number were found be remarkably active against AIDS virus. new class HIV-1-inhibitory compounds, sulfonic acid-containing glycolipids, discovered through use guide fractionation and purification process. The pure compounds HIV-1 in...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCirculins A and B. Novel human immunodeficiency virus (HIV)-inhibitory macrocyclic peptides from the tropical tree Chassalia parvifolia.Kirk R. Gustafson, Raymond C. Sowder II, Louis E. Henderson, Ian Parsons, Yoel Kashman, John H. Cardellina James McMahon, Robert W. Buckheit Jr., Lewis K. Pannell, Michael BoydCite this: J. Am. Chem. Soc. 1994, 116, 20, 9337–9338Publication Date (Print):October 1, 1994Publication History Published online1 May...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntineoplastic agents. 257. Isolation and structure of spongistatin 1George R. Pettit, Zbigniew A. Chicacz, Feng Gao, Cherry L. Herald, Michael Boyd, Jean M. Schmidt, John N. HooperCite this: J. Org. Chem. 1993, 58, 6, 1302–1304Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://doi.org/10.1021/jo00058a004RIGHTS & PERMISSIONSArticle Views598Altmetric-Citations247LEARN ABOUT THESE...
Two novel, highly potent, cytotoxic macrolides, salicylihalamides A (1) and B (2), were isolated from the sponge Haliclona sp. This new macrolide class incorporates salicylic acid, a 12-membered lactone ring, an enamide side chain. COMPARE pattern-recognition analyses of NCI 60-cell mean graph screening profiles 1 did not reveal any significant correlations to known antitumor compounds in NCI's "standard agent database", thus supporting conclusion that represent potentially important for...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnti-HIV Michellamines from Ancistrocladus korupensisMichael R. Boyd, Yali F. Hallock, John H. Cardellina II, Kirk P. Manfredi, W. Blunt, James B. McMahon, Robert Buckheit Jr., Gerhard Bringmann, Manuela Schäffer, Gordon M. Cragg, Duncan Thomas, and Johnson G. JatoCite this: J. Med. Chem. 1994, 37, 12, 1740–1745Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June...
A structure−activity relationship (SAR) study of the South African willow tree (Combretum caffrum) antineoplastic constituent combretastatin A-4 (1b) directed at maintaining (Z)-stilbene olefin diphenyl substituents led to synthesis a potent cancer cell growth inhibitor designated phenstatin (3b). Initially silyl ether (3a) was unexpectedly obtained by Jacobsen oxidation (1c → 3a), and parent (3b) later synthesized (6a 3a 3b) in quantity. Phenstatin converted sodium phosphate prodrug (3d)...