A5102970015- Soybean genetics and cultivation
- Peroxisome Proliferator-Activated Receptors
- Tryptophan and brain disorders
- Legume Nitrogen Fixing Symbiosis
- Stress Responses and Cortisol
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Function and Risk Factors
- Chemical Analysis and Environmental Impact
- Cancer-related gene regulation
- Traditional Chinese Medicine Analysis
- Marine Biology and Environmental Chemistry
- Free Radicals and Antioxidants
- Water Treatment and Disinfection
- Plant pathogens and resistance mechanisms
- Genetic Syndromes and Imprinting
- Nitric Oxide and Endothelin Effects
- Bipolar Disorder and Treatment
- Neurological Disease Mechanisms and Treatments
- Hippo pathway signaling and YAP/TAZ
- Mercury impact and mitigation studies
- Neurogenesis and neuroplasticity mechanisms
- Heavy Metal Exposure and Toxicity
- Metabolism, Diabetes, and Cancer
- Oxidative Organic Chemistry Reactions
- Histone Deacetylase Inhibitors Research
Chongqing Medical University
2015-2024
Dalian University
2009-2024
Chongqing Medical and Pharmaceutical College
2020-2024
Jilin Academy of Agricultural Sciences
2018-2024
Dalian Medical University
2009-2024
Peking University Shenzhen Hospital
2024
University of Hong Kong - Shenzhen Hospital
2024
First Hospital of Jiaxing
2022-2023
Affiliated Hospital of Nantong University
2017-2023
Nantong University
2017-2023
Perchlorate and chlorate are ubiquitous pollutants in various types of foodstuffs, drinking water environmental compartments. They have raised great concerns due to potential adverse effects on human thyroid functions. Dietary intake is considered as the predominant pathway for exposure perchlorate chlorate. Nevertheless, data chemicals above remain limited, particularly most vulnerable populations such infants. In present study, 62 breast milks, 53 infant formulas, 88 baby supplementary...
Abstract In-situ transmission electron microscopy (TEM), enabling the introduction of various stimuli into TEM sample chamber, is a powerful tool to observe dynamic structural transformation under external at atomic scale, and thus has attracted extensiveattentions in research materials science nanotechnology. In particular, massive studies using imaging beams as particular type have emerged up, it requires no additional experimental equipment or special specimen holders. This review...
Histone acetylation has been linked to depression, the etiology of which involves many factors such as genetics, environments, and epigenetics. The aim present study was investigate whether it associated with epigenetic histone modification gene expression enzymes responsible for biosynthesis norepinephrine serotonin in rat depression model induced by chronic unpredictable stress (CUS). Eight-week-old male Sprague-Dawley rats were exposed CUS over 28 days. It shown that CUS-induced displayed...
Endothelial damage caused by persistent glucose and lipid metabolism disorders is the main reason of diabetic vascular diseases.Daidzein exerts positive effects on dysfunction.Peroxisome proliferator-activated receptors (PPARs) regulate critically metabolism.However, interaction daidzein to PPARs still insufficiently explored.In this study, cell proliferation was detected EdU.The intrinsic activity binding affinity for human (hPPARs) were estimated transactivation reporter gene test HPLC-UV...
Soybean was domesticated about 5000 to 6000 years ago in China. Although genotyping technologies such as by sequencing (GBS) and high-density array are available, it is convenient economical genotype cultivars or populations using medium-density SNP genetic study well molecular breeding. In this study, 235 cultivars, collected from China, Japan, USA, Canada some other countries, were genotyped SoySNP8k iSelect BeadChip with 7189 single nucleotide polymorphisms (SNPs). total, 4471 polymorphic...
Abstract Ammonium tetrathiomolybdate (TTM) is a copper chelator in clinical trials for treatment of Wilson’s disease, tumors and other diseases. In the current study, we innovatively discovered that TTM novel NRF2 activator illustrated autophagy contributed to TTM-induced activation. We showed promoted nuclear translocation upregulated transcription level target genes including HMOX1 , GCLM SLC7A11 vascular endothelial cells (HUVECs). Moreover, deficiency directly hindered TTM-mediated...
Perchlorate, chlorate and bromate are ubiquitously present in the environment. Perchlorate could affect thyroid functions, while is carcinogenic has been listed as a possible human carcinogen group 2B by International Agency for Research on Cancer (IARC). This study aimed to determine occurrence of perchlorate, three types drinking water (n=226) Shenzhen, assess potential exposure risks. The detection rates perchlorate were both greater than 60%, they positively correlated bottled tap water,...
Rhizoma coptidis , the root of Coptis chinensis Franch has been used in China as a folk medicine treatment diabetes for thousands years. Berberine, one active ingredients reported to improve symptoms and treat experimental cardiac hypertrophy, respectively. The objective this study was evaluate potential effect berberine on cardiomyocyte hypertrophy its possible influence peroxisome proliferator-activated receptor- α (PPAR )/nitric oxide (NO) signaling pathway. induced by high glucose (25.5...
Lung adenocarcinoma (LADC)is a general form of non-small cell lung cancer that represents significant threat to public health worldwide. The 5-year-survival rate for LADC is currently below 15%. transcription factor KLF15, also called kidney-enriched KLF (KKLF), has been proven play role in inhibiting proliferation and diversification carcinoma cells, including those the endometrium, pancreas breast, but involvement KLF15 not previously studied. In this study, we compared vitro expression...
Polydatin, a natural component from Polygonum Cuspidatum, has important therapeutic effects on metabolic syndrome. A novel strategy using polydatin to improve vascular function recently been proposed treat diabetes-related cardiovascular complications. However, the biological role and molecular basis of polydatin's action endothelial cells (VECs)-mediated vasodilatation under hyperglycemia condition remain elusive. The present study aimed assess contribution in restoring...
Venlafaxine (VEN) is a widely used antidepressant as serotonin-reuptake and norepinephrine-reuptake inhibitor. It primarily in depression, especially with generalized anxiety disorder or chronic pain. This medicine of interest because its mechanisms involved multiple aspects. In the current study, action VEN was investigated by studying histone acetylation expression tyrosine hydroxylase (TH) tryptophan (TPH) rats exposed to unpredicted stress (CUS) for 28 days. Male Sprague-Dawley were...
The available treatments for the abnormal proliferation of vascular smooth muscle cells (VSMCs) are still dismal. Berberine has been demonstrated to possess extensive medicine activity, yet relatively little is known about its effect on VSMCs proliferation. Many studies showed that PPARα and NO participated in process proliferation.To evaluate berberine possible influence PPARα-NO pathway angiotensin IV-stimulated VSMCs.The primary were cultured with tissue explants method, was characterized...
Cardiac hypertrophy is a key pathological process in the context of diabetic cardiomyopathy. Naringenin exhibits multiple pharmacological activities, but effect naringenin on cardiomyocyte under conditions still far from clear.Cardiomyocyte was induced by high glucose (HG, at 25.5 mmol/L) H9c2 cells, which determined cell surface area, protein content and atrial natriuretic factor (ANF) mRNA expression. The observed its mechanisms were investigated administration with various inhibitors...
Fibronectin (FN) type III domain containing 3B (FNDC3B), a member of the FN family, regulates invasion and metastasis cells in numerous tumor types. However, mechanisms through which FNDC3B carcinogenesis lung adenocarcinoma (LADC) tissues have remained elusive. The present study revealed that protein levels vimentin were significantly elevated LADC compared with those normal tissues. By contrast, expression E-cadherin was decreased Furthermore, aberrant epithelial-mesenchymal transition...
Depression is a common worldwide mental disorder whose etiology remains unclear; there also lack of effective therapeutic agents. Sodium valproate (VPA) traditional antiepileptic drug with mood-stabilization effect and increasingly being used to treat bipolar disorders depression, but its antidepressant mechanism unknown. The aim the present study was investigate possible mechanisms action by studying malondialdehyde level, catalase, superoxide dismutase activities in serum mRNA protein...