A5013798200- Neonatal and fetal brain pathology
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Erythrocyte Function and Pathophysiology
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Advanced Neuroimaging Techniques and Applications
- Circadian rhythm and melatonin
- Neurotransmitter Receptor Influence on Behavior
- Biochemical Analysis and Sensing Techniques
- Optical Imaging and Spectroscopy Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Blood properties and coagulation
- Functional Brain Connectivity Studies
- Cerebrovascular and genetic disorders
- Acute Ischemic Stroke Management
- S100 Proteins and Annexins
- Traditional Chinese Medicine Studies
- Memory and Neural Mechanisms
- Healthcare and Venom Research
- Tryptophan and brain disorders
- Ion channel regulation and function
- Neurological disorders and treatments
- Opioid Use Disorder Treatment
Beijing Institute of Technology
2025
Saarland University
2021-2024
University of Calgary
2012-2024
University of Rochester Medical Center
2023-2024
Allen Institute for Brain Science
2024
Beth Israel Deaconess Medical Center
2024
Harvard University
2024
Boston Children's Hospital
2024
University of Newcastle Australia
2024
Tufts University
2024
Circuit-specific signaling of ventral tegmental area (VTA) dopamine neurons drives different aspects motivated behavior, but the neuromodulatory control these circuits is unclear. We tested actions co-expressed lateral hypothalamic peptides, orexin A (oxA) and dynorphin (dyn), on projection-target-defined in mice. determined that VTA project to nucleus accumbens shell (lAcbSh), medial (mAcbSh), basolateral amygdala (BLA) are largely non-overlapping cell populations with electrophysiological...
Significance Consumption of palatable food or food-related advertising can prime increased intake, potentially leading to overeating. We show that short-term exposure foods induces long-lasting synaptic plasticity in mesolimbic dopamine neurons. Furthermore, sweetened high-fat drive approach behaviors and consumption days after the initial exposure. Suppressing excitatory transmission ventral tegmental area reverse consumption. Targeting this circuit with brain-delivered insulin may provide...
The Gárdos channel (KCNN4) and Piezo1 are the best-known ion channels in red blood cell (RBC) membrane. Nevertheless, quantitative electrophysiological behavior of RBCs its heterogeneity still not completely understood. Here, we use state-of-the-art biochemical methods to probe for abundance RBCs. Furthermore, utilize automated patch clamp, based on planar chips, compare activity two reticulocytes mature In addition this characterization, performed membrane potential measurements demonstrate...
Ischemically damaged brain can be accompanied by secondary degeneration of associated axonal connections e.g. Wallerian degeneration. Diffusion tensor imaging (DTI) is widely used to investigate injury but the cellular correlates many degenerative changes remain speculative. We investigated relationship DTI directly cerebral cortex and in peduncle with alterations pan-axonal neurofilament staining, myelination, reactive astrocytes, activation microglia/macrophages neuronal cell death....
Overconsumption of highly palatable, energy-dense food is considered a key driver the obesity pandemic. The orbitofrontal cortex (OFC) critical for reward valuation gustatory signals, yet how OFC adapts to obesogenic diets poorly understood. Here, we show that extended access cafeteria diet impairs astrocyte glutamate clearance, which leads heterosynaptic depression GABA transmission onto pyramidal neurons OFC. This decrease in tone due an increase extrasynaptic glutamate, acts via...
Reward and reinforcement processes are critical for survival propagation of genes. While numerous brain systems underlie these processes, a cardinal role is ascribed to mesolimbic dopamine. However, ventral tegmental area (VTA) dopamine neurons receive complex innervation various neuromodulatory factors, including input from lateral hypothalamic (LH) orexin/hypocretin which also express co-release the neuropeptide, dynorphin. Dynorphin in VTA induces aversive conditioning through Kappa...
Abstract Background Studies have shown that a significant percentage of patients with obstructive sleep apnea (OSA) do not tolerate continuous positive airway pressure (CPAP) therapy and long-term use may be as low 30%. Given the lower levels symptoms health-related risks, mild at even higher risk for non-adherence to long term CPAP. The purpose our study was investigate prevalence associations CPAP adherence in first time users diagnosed by home testing (HSAT). Methods We identified all who...
Abstract Whether the water channel protein AQP4 is involved in very early cell swelling and brain oedema observed with cerebral hypoxia–ischaemia (HI) whether this response depends on maturity of were investigated by comparing regional changes expression signal intensity magnetic resonance (MR) images immature juvenile brains. Maps T2 apparent diffusion coefficient (ADC) acquired 1‐ 4‐week‐old rats at times prior to HI, within last 5 min HI 1 h or 24 afterwards. assessed Western blotting was...
Pancreatic beta cell dysfunction caused by metabolic and inflammatory stress contributes to the development of type 2 diabetes (T2D). Butyrate, produced gut microbiota, has shown beneficial effects on glucose metabolism in animals humans may directly affect function, but mechanisms are poorly described. The aim this study was investigate effect butyrate cytokine-induced vitro. Mouse islets, rat INS-1E, human EndoC-βH1 cells were exposed long-term non-cytotoxic concentrations cytokines and/or...
To investigate the correlation between diffusion-weighted (DW) magnetic resonance (MR) image changes with alterations in extracellular volume and cytochrome oxidase Na(+)-K(+)-adenosine triphosphatase (ATPase) activity at various times during after cerebral hypoxia-ischemia neonatal juvenile rats.One- 4-week-old rats were randomly assigned to control or transient (ie, right carotid artery occlusion plus exposure 8% oxygen) groups. Hypoxic-ischemic compared normal ipsilateral brain tissue on...
Introduction The unique red blood cell (RBC) properties that characterize the rare neuroacanthocytosis syndromes (NAS) have prompted exploration of osmotic gradient ektacytometry (Osmoscan) as a diagnostic tool for these disorders. In this exploratory study, we assessed if Osmoscans can discriminate NAS from other neurodegenerative diseases. Methods A comprehensive assessment was conducted using Osmoscan on diverse group patients, including healthy controls ( n = 9), syndrome patients 6, 2...
Dopamine (DA) neurons in the ventral tegmental area (VTA) respond to motivationally relevant cues, and circuit-specific signaling drives different aspects of motivated behavior. Orexin (ox; also known as hypocretin) dynorphin (dyn) are coexpressed lateral hypothalamic (LH) neuropeptides that project VTA. These peptides have opposing effects on firing activity VTA
Age-dependent changes in T2-weighted MR images have been reported cerebral hypoxia-ischemia. However, the biophysical mechanisms responsible for image remain poorly defined. We investigated whether hypoxia-ischemia-induced T2 correlate with alterations either water content or protein extravasation.One- and 4-week-old rats were subjected to unilateral carotid artery occlusion plus hypoxia 8% oxygen. acquired before, during, 1 24 hours after Blood-brain barrier disruption brain edema evaluated...
The orbitofrontal cortex (OFC) plays a critical role in evaluating outcomes changing environment. Administering opioids to the OFC can alter hedonic reaction food rewards and increase their consumption subregion-specific manner. However, it is unknown how mu-opioid signaling influences synaptic transmission OFC. Thus, we investigated cellular actions of mu-opioids within distinct subregions Using <i>in vitro</i> patch-clamp electrophysiology brain slices containing OFC, found that agonist...
Abstract Peripheral inflammatory conditions, including those localized to the gastrointestinal tract, are highly comorbid with psychiatric disorders such as anxiety and depression. These behavioral symptoms poorly managed by conventional treatments for diseases contribute quality of life impairments. inflammation is associated sustained elevations in circulating glucocorticoid hormones, which can modulate central processes, involved regulation emotional behavior. The endocannabinoid (eCB)...
Summary: Purpose : To determine whether the neuropathologic changes produced by vigabatrin (VGB; γ‐vinyl GABA) administration in developing rat brain are reversible. Methods We injected rats daily with VGB (25–40 mg/kg/day, s.c.) from age 12 days for 2 weeks followed of a drug‐free period. Behavioral testing, magnetic resonance (MR) imaging, biochemical assays, and histologic technique were used to assess adverse effect its reversibility. Results At end weeks' administration: (a) there was...
Venlafaxine (VEN) is a widely used antidepressant as serotonin-reuptake and norepinephrine-reuptake inhibitor. It primarily in depression, especially with generalized anxiety disorder or chronic pain. This medicine of interest because its mechanisms involved multiple aspects. In the current study, action VEN was investigated by studying histone acetylation expression tyrosine hydroxylase (TH) tryptophan (TPH) rats exposed to unpredicted stress (CUS) for 28 days. Male Sprague-Dawley were...
Transient ischemic attack, minor stroke and recurrence need improved treatment but lack animal models for research. The aim was to modify photothrombosis methods thereby producing both a (with adjacent mild damage) or recurrent stroke.A stroke, as detected using magnetic resonance imaging histology, produced low intensity beam of white light with bright centre, dose Rose Bengal short 5min illumination thinned skull. A by repeating the procedure two days later except cortical mask positioned...